Microalbuminuria and Diabetic Pregnancy
Renal and vascular damage, including blood pressure elevation, is often involved in complications of diabetic pregnancy. Therefore, sensitive methods for measuring elevated urinary protein excretion, especially of albumin (so-called microalbuminuria) [1–3], might be useful in early prediction of complications in diabetic as well as nondiabetic pregnancy. This is the case in nonpregnant diabetics [3–9], in whom microalbuminuria is a sensitive marker of generalized subclinical vascular disturbance and damage  and in whom it predicts overt nephropathy [3–6] as well as proliferative retinopathy . This chapter deals with the pattern of urinary albumin excretion rate in diabetic pregnancy as studied with a sensitive radioimmunoassay for albumin using 24-h urine samples. Patients with overt nephropathy are discussed in Chapter 37.
KeywordsDiabetic Nephropathy Mean Arterial Pressure Proliferative Diabetic Retinopathy Urinary Albumin Excretion Urinary Albumin Excretion Rate
Unable to display preview. Download preview PDF.
- 5.Parving H-H, Oxenbell B, Svendsen PAa, Christiansen JS, Andersen AR. Early detection of patients at risk of developing diabetic nephropathy: a longitudinal study of urinary albumin excretion. Acta Endocrinol (Copenh) 1982; 100: 550–555.Google Scholar
- 7.Vigstrup J, Mogensen CE. Proliferative diabetic retinopathy: at risk patients identified by early detection of microalbuminuria. Acta Ophthalmol 1985; 63: 530–534.Google Scholar
- 11.Mogensen CE. Microalbuminuria and kidney function in diabetes: Notes on methods, interpretation and classification. In: Clarke WL, Lamer J, Pohl SL (eds). Methods in Diabetes Research, volume II: Clinical Methods. New York, Chichester, Brisbane, Toronto, Singapore: John Wiley & Sons; 1986; pp. 611–631.Google Scholar
- 13.Pedersen EB, Rasmussen AB, Johannesen P, Lauritsen JG, Kristensen S, Mogensen CE, Selling K, Wohlert M. Urinary excretion of albumin, beta-2-microglobulin and light chains in preeclampsia, essential hypertension in pregnancy and normotensive pregnant and non-pregnant control subjects. Scand J Clin Lab Invest 1982; 41: 777–784.CrossRefGoogle Scholar
- 17.Pedersen J. The pregnant diabetic and her newborn, 2nd ed. Copenhagen: Munksgaard; 1977.Google Scholar
- 20.Mogensen CE, Poulsen PL, Heinsvig EM. Abnormal albuminuria in the monitoring of early renal changes in diabetes. In: Mogensen CE, Standi E (eds). Concepts for the Ideal Diabetes Clinic. Diabetes Forum Series, Volume 4. Berlin, New York: Walter de Gruyter; 1993; pp. 289–313.Google Scholar