Meta-Analysis of the Effect of Intensive Therapy on Nephropathy in Type I Diabetes Mellitus
The large-scale Diabetes Control and Complication Trial (DCCT) has convincingly demonstrated the benefits of intensive therapy on diabetic nephropathy, neuropathy, and retinopathy . A meta-analysis of several smaller studies also reached the same conclusions on nephropathy and retinopathy . Decades of debate over whether normalization of hyperglycaemia may retard or delay microvascular complications came to an end [3, 4]. As more randomized-controlled trials in diabetic patients are being conducted, meta-analysis will be a useful tool to study interventions in the prevention of diabetic complications. In this chapter, we review the principle, strengths, and limitations of meta-analysis and the results of meta-analysis of intensive glycaemic control on diabetic nephropathy. The clinical implications of intensive therapy, based on the results of DCCT and meta-analysis, are also discussed.
KeywordsDiabetic Nephropathy Glycaemic Control Microvascular Complication Urinary Albumin Excretion Intensive Therapy
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