Familial Factors in Diabetic Nephropathy

  • David J. Pettitt
  • William C. Knowler


Reports of nephropathy developing in some patients with apparently well controlled diabetes and not developing in some patients even after years of severe hyperglycemia lead to the conclusion, expressed by several researchers [1–5], that some individuals are and others are not predisposed to the development of diabetic renal disease. If this predisposition is genetic, there must be an interaction between the genes and the environment, and it is often impossible to differentiate between genetic inheritance and the effect of a common environment shared by family members. This chapter reviews some of the data which indicate that there are familial differences in the predisposition to the development of diabetic renal disease.


Renal Disease Diabetic Nephropathy Diabetic Kidney Disease Familial Factor Diabetic Microangiopathy 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • David J. Pettitt
  • William C. Knowler

There are no affiliations available

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