Early Renal Hyperfunction and Hypertrophy in IDDM Patients Including Comments on Early Intervention

  • Margrethe Mau Pedersen

Abstract

Since diabetic nephropathy constitutes the principal background for reduced survival in insulin-dependent diabetes, much interest is being paid to early alterations in kidney function and structure, and to the possible relationship between such early abnormalities and later development of diabetic nephropathy. A modest increase in urinary albumin excretion, microalbuminuria, has been identified as an early marker of diabetic nephropathy, and interventions postponing the onset of overt nephropathy has been introduced. In this chapter the earliest renal changes in IDDM, glomerular hyperfunction and renal hypertrophy, will be addressed.

Keywords

Glomerular Filtration Rate Diabetic Nephropathy Atrial Natriuretic Peptide Urinary Albumin Excretion Renal Plasma Flow 
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© Springer Science+Business Media New York 1994

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  • Margrethe Mau Pedersen

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