Abstract
Diabetic nephropathy is the main cause of the increased morbidity and mortality among patients with Type 1 diabetes [1,2,3]. In recent years it has been shown that a slightly elevated urinary albumin excretion rate (microalbuminuria) is an early predictor for later development of manifest diabetic nephropathy [4,5,6], The presence of hypertension in the diabetic individual markedly increases the risk and accelerates the course of the diabetic kidney disease [7]. Given the poor prognosis for patients developing manifest diabetic nephropathy emphasize the need for a uniform intervention programme for treatment of microalbuminuria in children and adolescents with Type 1 diabetes.
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References
Deckert T, Poulsen JE, Larsen M. Prognosis of diabetics with diabetes onset before age of thirty-one. Diabetologia 1978; 14: 363–370.
Dorman JS, Laporte RE, Kuller LH, Cruickshanks KJ, Orchard TJ, Wagener DK, Becker DJ, Cavender DE, Drash AL. The Pittsburgh insulin-dependent diabetes mellitus (IDDM). Morbidity and mortality study. Mortality results. Diabetes 1984; 33: 271–276.
Borch-Johnsen K, Kreiner S. Proteinuria: value as predictor of cardiovascular mortality in insulin dependent diabetes mellitus. BMJ 1987; 294: 1651–1654.
Viberti GC, Hill RD, Jarrett RJ, Argyropoulos A, Mahmud U, Keen H. Microalbuminuria as a predictor of clinical nephropathy in insulin-dependent diabetes mellitus. Lancet 1982; i: 1430–1432.
Parving H-H, Oxenbøll B, Svendsen PAA, Christiansen JS, Andersen AR. Early detection of patients at risk of developing diabetic nephropathy. A longitudinal study of urinary albumin excretion. Acta Endocrinol (Copenh) 1982; 100: 550–555.
Mogensen CE, Christensen CK. Predicting diabetic nephropathy in insulin-dependent patients. N Engl J Med 1984; 311: 89–93.
Epstein M, Sowers JR. Diabetes mellitus and Hypertension. Hypertension 1992; 19: 403–418.
Mortensen HB, Marinelli K, Nørgaard K, Main K, Kastrup KW, Ibsen KK, et al. A nation-wide cross-sectional study of urinary albumin excretion rate, arterial blood pressure and blood glucose control in Danish children with Type 1 diabetes. Diabetic Med 1990; 7: 887–897.
Tomaselli L, Trischitta V, Vinci C, Frittitta L, Squatrito S, Vigneri R. Evaluation of albumin excretion rate in overnight versus 24-h urine. Diabetes Care 1989; 12: 585–587.
Cowell CT, Rogers S, Silink M. First morning urinary albumin excretion in children with Type 1 (insulin-dependent) diabetes. Diabetologia 1986; 29: 97–99.
Davies AG, Postlethwaite, Price DA, Burn JL, Houlton CA, Fielding BA. Urinary albumin excretion in school children. Arch Dis Child 1984; 59: 625–630.
Rowe DJF, Hayward M, Bagga H, Betts P. Effect of glycaemic control and duration of disease on overnight albumin excretion in diabetic children. BMJ 1984; 289: 957–959.
Mathiesen ER, Saurbrey N, Hommel E, Parving H-H. Prevalence of microalbuminuria in children with Type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1986; 29: 640–643.
Nørgaard N, Storm B, Graa M, Feldt-Rasmussen B. Elevated albumin excretion and retinal changes in children with Type 1 diabetes are related to long-term poor blood glucose control. Diabetic Med 1989; 6: 325–328.
D’Antonio JA, Ellis D, Doft BH, Becker DJ, Drash AL, Kuller LH, Orchard TJ. Diabetic complications and glycemic control. The Pittsburgh prospective insulin-dependent diabetes cohort study status report after 5 yr of IDDM. Diabetes Care 1989; 12: 694–700.
Joner G, Brinchmann-Hansen O, Torres CG, Hanssen KF. A nationwide cross-sectional study of retinopathy and microalbuminuria in young Norwegian Type 1 (insulin-dependent) diabetic patients. Diabetologia 1992; 35: 1049–1054.
Dahlquist G, Rudberg S. The prevalence of microalbuminuria in diabetic children and adolescents and its relation to puberty. Acta Pædiatr Scand 1987; 76: 795–800.
Wisemann M, Viberti GC, Mackintosh D, Jarrett RJ, Keen H. Glycaemia, arterial pressure and micro-albuminuria in Type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1984; 26: 401–405.
Davies AG, Price DA, Postlethwaite RJ, Addison GM, Burn JL, Fielding BA. Renal function in diabetes mellitus. Arch Dis Child 1985; 60: 299–304.
Mortensen HB, Hartling SG, Petersen KE, and the Danish Study Group of Diabetes in Childhood. A nation-wide cross-sectional study of glycosylated haemoglobin in Danish children with Type 1 diabetes. Diabetic Med 1988; 5: 871–876.
Mortensen HB, Villumsen J, Volund AA, Petersen KE, Nerup J and The Danish Study Group of Diabetes in Childhood. Relationship between insulin injection regimen and metabolic control in young Danish Type 1 diabetic patients. Diabetic Med 1992; 9: 834–839.
Feldt-Rasmussen B, Mathiesen ER, Deckert T. Effect of two years of strict metabolic control on progression of incipient nephropathy in insulin-dependent diabetes. Lancet 1986; ii: 1300–1304.
The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329: 977–986.
Mortensen HB, Hougaard P, Ibsen KK, Parving H-H and The Danish Study Group of Diabetes in Childhood. Relationship between blood pressure and urinary albumin excretion rate in young Danish Type 1 diabetic patients: Comparison to Non-diabetic children. Diabetic Med 1994; in press.
Mogensen CE, Christensen CK, Christiansen JS, Boye N, Pedersen MM, Schmitz A. Early hyperfiltration and late renal damage in insulin-dependent diabetes. Pediatr Adolesc Endocrinol 1988; 17: 197–205.
Mogensen CE. Microalbuminuria as a predictor of clinical diabetic nephropathy. Kidney Int 1987; 31: 673–689.
Feldt-Rasmussen B, Mathiesen ER, Deckert T, Giese J, Christensen NJ, Bent-Hansen L, et al. Central role for sodium in the pathogenesis of blood pressure changes independent of angiotensin, aldosterone and catecholamines in type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1987; 30: 610–617.
Cook J, Daneman D, Spino M, Sochett E, Perlman K, Balfe JW. Angiotensin converting enzyme inhibitor therapy to decrease microalbuminuria in normotensive children with insulin-dependent diabetes mellitus. J Pediatr 1990; 117: 39–45.
Marre M, Chatellier G, Leblanc H, Guyene TT, Menard J, Passa P. Prevention of diabetic nephropathy with enalapril in normotensive diabetics with microalbuminuria. BMJ 1988; 297: 1092–1095.
Mathiesen ER, Hommel E, Giese J, Parving H-H. Efficacy of Captopril in postponing nephropathy in normotensive insulin dependent diabetic patients with microalbuminuria. BMJ 1991; 303: 81–87.
Mogensen CE and the European Microalbuminuria Captopril Study Group. Captopril (C) delays progression to overt renal disease in insulin-dependent diabetes mellitus (IDDM) patients with microalbuminuria. J Am Soc Nephrol 1992; 3: 336 (abstract).
Mathiesen ER, R0nn B, Jensen T, Storm B, Deckert T. Relation between blood pressure and urinary albumin excretion in development of microalbuminuria. Diabetes 1990; 39: 245–249.
Mathiesen ER, Saurbrey N, Hommel E, Parving H-H. Prevalence of microalbuminuria in children with Type 1 (insulin-dependent diabetes mellitus). Diabetologia 1986; 29: 640–643.
Tarn AC, Drury PL. Blood pressure in children, adolescents and young adults with Type 1 (insulin-dependent) diabetes. Diabetologia 1986; 29: 275–281.
Viberti GC, Bending JJ. Early diabetic nephropathy. Detection and prevention. Adv Nephrol 1988; 17: 101–112.
Parving H-H, Hommel E, Mathiesen E, Skøtt P, Edsberg B, Bahnsen M, et al. Prevalence of microalbuminuria, arterial hypertension, retinopathy and neuropathy in patients with insulin dependent diabetes. BMJ 1988; 296: 156–160.
Parving H-H, Andersen AR, Smidt UM, Christiansen JS, Oxenbøll B, Svendsen PA. Diabetic nephropathy and arterial hypertension. The effect of antihypertensive treatment. Diabetes 1983; 32: suppl.: 83–87.
Wiseman M, Viberti GC, Mackintosh D, Jarrett RJ, Keen H. Glycemia, arterial pressure and micro-albuminuria in type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1988; 26: 401–405.
Zusman RM. Renin- and non-renin-mediated antihypertensive actions of converting enzyme inhibitors. Kidney Int 1984; 25: 969–983.
Anderson S, Brenner BM. Pathogenesis of diabetic glomerulopathy: Hemodynamic considerations. Diabetes Metab Rev 1988; 4: 163–177.
Frohlich ED, Cooper RA, Lewis EJ. Review of the overall experience of Captopril in hypertension. Arch Intern Med 1984; 144: 1441–1444.
Mirkin BL, Newman TJ. Efficacy and safety of Captopril in the treatment of severe childhood hypertension: report of the International Collaborative Study Group. Pediatrics 1985; 75: 1091–1100.
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Mortensen, H.B. (1994). Microalbuminuria in Young Patients with Type 1 Diabetes. In: Mogensen, C.E. (eds) The Kidney and Hypertension in Diabetes Mellitus. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6746-9_27
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DOI: https://doi.org/10.1007/978-1-4757-6746-9_27
Publisher Name: Springer, Boston, MA
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