Skip to main content

Microalbuminuria in Young Patients with Type 1 Diabetes

  • Chapter
The Kidney and Hypertension in Diabetes Mellitus

Abstract

Diabetic nephropathy is the main cause of the increased morbidity and mortality among patients with Type 1 diabetes [1,2,3]. In recent years it has been shown that a slightly elevated urinary albumin excretion rate (microalbuminuria) is an early predictor for later development of manifest diabetic nephropathy [4,5,6], The presence of hypertension in the diabetic individual markedly increases the risk and accelerates the course of the diabetic kidney disease [7]. Given the poor prognosis for patients developing manifest diabetic nephropathy emphasize the need for a uniform intervention programme for treatment of microalbuminuria in children and adolescents with Type 1 diabetes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Deckert T, Poulsen JE, Larsen M. Prognosis of diabetics with diabetes onset before age of thirty-one. Diabetologia 1978; 14: 363–370.

    Article  PubMed  CAS  Google Scholar 

  2. Dorman JS, Laporte RE, Kuller LH, Cruickshanks KJ, Orchard TJ, Wagener DK, Becker DJ, Cavender DE, Drash AL. The Pittsburgh insulin-dependent diabetes mellitus (IDDM). Morbidity and mortality study. Mortality results. Diabetes 1984; 33: 271–276.

    Article  PubMed  CAS  Google Scholar 

  3. Borch-Johnsen K, Kreiner S. Proteinuria: value as predictor of cardiovascular mortality in insulin dependent diabetes mellitus. BMJ 1987; 294: 1651–1654.

    Article  PubMed  CAS  Google Scholar 

  4. Viberti GC, Hill RD, Jarrett RJ, Argyropoulos A, Mahmud U, Keen H. Microalbuminuria as a predictor of clinical nephropathy in insulin-dependent diabetes mellitus. Lancet 1982; i: 1430–1432.

    Article  Google Scholar 

  5. Parving H-H, Oxenbøll B, Svendsen PAA, Christiansen JS, Andersen AR. Early detection of patients at risk of developing diabetic nephropathy. A longitudinal study of urinary albumin excretion. Acta Endocrinol (Copenh) 1982; 100: 550–555.

    CAS  Google Scholar 

  6. Mogensen CE, Christensen CK. Predicting diabetic nephropathy in insulin-dependent patients. N Engl J Med 1984; 311: 89–93.

    Article  PubMed  CAS  Google Scholar 

  7. Epstein M, Sowers JR. Diabetes mellitus and Hypertension. Hypertension 1992; 19: 403–418.

    Article  PubMed  CAS  Google Scholar 

  8. Mortensen HB, Marinelli K, Nørgaard K, Main K, Kastrup KW, Ibsen KK, et al. A nation-wide cross-sectional study of urinary albumin excretion rate, arterial blood pressure and blood glucose control in Danish children with Type 1 diabetes. Diabetic Med 1990; 7: 887–897.

    Article  PubMed  CAS  Google Scholar 

  9. Tomaselli L, Trischitta V, Vinci C, Frittitta L, Squatrito S, Vigneri R. Evaluation of albumin excretion rate in overnight versus 24-h urine. Diabetes Care 1989; 12: 585–587.

    Article  PubMed  CAS  Google Scholar 

  10. Cowell CT, Rogers S, Silink M. First morning urinary albumin excretion in children with Type 1 (insulin-dependent) diabetes. Diabetologia 1986; 29: 97–99.

    Article  PubMed  CAS  Google Scholar 

  11. Davies AG, Postlethwaite, Price DA, Burn JL, Houlton CA, Fielding BA. Urinary albumin excretion in school children. Arch Dis Child 1984; 59: 625–630.

    Article  PubMed  CAS  Google Scholar 

  12. Rowe DJF, Hayward M, Bagga H, Betts P. Effect of glycaemic control and duration of disease on overnight albumin excretion in diabetic children. BMJ 1984; 289: 957–959.

    Article  PubMed  CAS  Google Scholar 

  13. Mathiesen ER, Saurbrey N, Hommel E, Parving H-H. Prevalence of microalbuminuria in children with Type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1986; 29: 640–643.

    Article  PubMed  CAS  Google Scholar 

  14. Nørgaard N, Storm B, Graa M, Feldt-Rasmussen B. Elevated albumin excretion and retinal changes in children with Type 1 diabetes are related to long-term poor blood glucose control. Diabetic Med 1989; 6: 325–328.

    Article  PubMed  Google Scholar 

  15. D’Antonio JA, Ellis D, Doft BH, Becker DJ, Drash AL, Kuller LH, Orchard TJ. Diabetic complications and glycemic control. The Pittsburgh prospective insulin-dependent diabetes cohort study status report after 5 yr of IDDM. Diabetes Care 1989; 12: 694–700.

    Article  PubMed  Google Scholar 

  16. Joner G, Brinchmann-Hansen O, Torres CG, Hanssen KF. A nationwide cross-sectional study of retinopathy and microalbuminuria in young Norwegian Type 1 (insulin-dependent) diabetic patients. Diabetologia 1992; 35: 1049–1054.

    Article  PubMed  CAS  Google Scholar 

  17. Dahlquist G, Rudberg S. The prevalence of microalbuminuria in diabetic children and adolescents and its relation to puberty. Acta Pædiatr Scand 1987; 76: 795–800.

    Article  PubMed  CAS  Google Scholar 

  18. Wisemann M, Viberti GC, Mackintosh D, Jarrett RJ, Keen H. Glycaemia, arterial pressure and micro-albuminuria in Type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1984; 26: 401–405.

    Google Scholar 

  19. Davies AG, Price DA, Postlethwaite RJ, Addison GM, Burn JL, Fielding BA. Renal function in diabetes mellitus. Arch Dis Child 1985; 60: 299–304.

    Article  PubMed  CAS  Google Scholar 

  20. Mortensen HB, Hartling SG, Petersen KE, and the Danish Study Group of Diabetes in Childhood. A nation-wide cross-sectional study of glycosylated haemoglobin in Danish children with Type 1 diabetes. Diabetic Med 1988; 5: 871–876.

    Article  PubMed  CAS  Google Scholar 

  21. Mortensen HB, Villumsen J, Volund AA, Petersen KE, Nerup J and The Danish Study Group of Diabetes in Childhood. Relationship between insulin injection regimen and metabolic control in young Danish Type 1 diabetic patients. Diabetic Med 1992; 9: 834–839.

    Article  PubMed  CAS  Google Scholar 

  22. Feldt-Rasmussen B, Mathiesen ER, Deckert T. Effect of two years of strict metabolic control on progression of incipient nephropathy in insulin-dependent diabetes. Lancet 1986; ii: 1300–1304.

    Article  Google Scholar 

  23. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329: 977–986.

    Article  Google Scholar 

  24. Mortensen HB, Hougaard P, Ibsen KK, Parving H-H and The Danish Study Group of Diabetes in Childhood. Relationship between blood pressure and urinary albumin excretion rate in young Danish Type 1 diabetic patients: Comparison to Non-diabetic children. Diabetic Med 1994; in press.

    Google Scholar 

  25. Mogensen CE, Christensen CK, Christiansen JS, Boye N, Pedersen MM, Schmitz A. Early hyperfiltration and late renal damage in insulin-dependent diabetes. Pediatr Adolesc Endocrinol 1988; 17: 197–205.

    Google Scholar 

  26. Mogensen CE. Microalbuminuria as a predictor of clinical diabetic nephropathy. Kidney Int 1987; 31: 673–689.

    Article  PubMed  CAS  Google Scholar 

  27. Feldt-Rasmussen B, Mathiesen ER, Deckert T, Giese J, Christensen NJ, Bent-Hansen L, et al. Central role for sodium in the pathogenesis of blood pressure changes independent of angiotensin, aldosterone and catecholamines in type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1987; 30: 610–617.

    PubMed  CAS  Google Scholar 

  28. Cook J, Daneman D, Spino M, Sochett E, Perlman K, Balfe JW. Angiotensin converting enzyme inhibitor therapy to decrease microalbuminuria in normotensive children with insulin-dependent diabetes mellitus. J Pediatr 1990; 117: 39–45.

    Article  PubMed  CAS  Google Scholar 

  29. Marre M, Chatellier G, Leblanc H, Guyene TT, Menard J, Passa P. Prevention of diabetic nephropathy with enalapril in normotensive diabetics with microalbuminuria. BMJ 1988; 297: 1092–1095.

    Article  PubMed  CAS  Google Scholar 

  30. Mathiesen ER, Hommel E, Giese J, Parving H-H. Efficacy of Captopril in postponing nephropathy in normotensive insulin dependent diabetic patients with microalbuminuria. BMJ 1991; 303: 81–87.

    Article  PubMed  CAS  Google Scholar 

  31. Mogensen CE and the European Microalbuminuria Captopril Study Group. Captopril (C) delays progression to overt renal disease in insulin-dependent diabetes mellitus (IDDM) patients with microalbuminuria. J Am Soc Nephrol 1992; 3: 336 (abstract).

    Google Scholar 

  32. Mathiesen ER, R0nn B, Jensen T, Storm B, Deckert T. Relation between blood pressure and urinary albumin excretion in development of microalbuminuria. Diabetes 1990; 39: 245–249.

    Article  PubMed  CAS  Google Scholar 

  33. Mathiesen ER, Saurbrey N, Hommel E, Parving H-H. Prevalence of microalbuminuria in children with Type 1 (insulin-dependent diabetes mellitus). Diabetologia 1986; 29: 640–643.

    Article  PubMed  CAS  Google Scholar 

  34. Tarn AC, Drury PL. Blood pressure in children, adolescents and young adults with Type 1 (insulin-dependent) diabetes. Diabetologia 1986; 29: 275–281.

    Article  PubMed  CAS  Google Scholar 

  35. Viberti GC, Bending JJ. Early diabetic nephropathy. Detection and prevention. Adv Nephrol 1988; 17: 101–112.

    CAS  Google Scholar 

  36. Parving H-H, Hommel E, Mathiesen E, Skøtt P, Edsberg B, Bahnsen M, et al. Prevalence of microalbuminuria, arterial hypertension, retinopathy and neuropathy in patients with insulin dependent diabetes. BMJ 1988; 296: 156–160.

    Article  PubMed  CAS  Google Scholar 

  37. Parving H-H, Andersen AR, Smidt UM, Christiansen JS, Oxenbøll B, Svendsen PA. Diabetic nephropathy and arterial hypertension. The effect of antihypertensive treatment. Diabetes 1983; 32: suppl.: 83–87.

    PubMed  Google Scholar 

  38. Wiseman M, Viberti GC, Mackintosh D, Jarrett RJ, Keen H. Glycemia, arterial pressure and micro-albuminuria in type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1988; 26: 401–405.

    Google Scholar 

  39. Zusman RM. Renin- and non-renin-mediated antihypertensive actions of converting enzyme inhibitors. Kidney Int 1984; 25: 969–983.

    Article  PubMed  CAS  Google Scholar 

  40. Anderson S, Brenner BM. Pathogenesis of diabetic glomerulopathy: Hemodynamic considerations. Diabetes Metab Rev 1988; 4: 163–177.

    Article  PubMed  CAS  Google Scholar 

  41. Frohlich ED, Cooper RA, Lewis EJ. Review of the overall experience of Captopril in hypertension. Arch Intern Med 1984; 144: 1441–1444.

    Article  PubMed  CAS  Google Scholar 

  42. Mirkin BL, Newman TJ. Efficacy and safety of Captopril in the treatment of severe childhood hypertension: report of the International Collaborative Study Group. Pediatrics 1985; 75: 1091–1100.

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Science+Business Media New York

About this chapter

Cite this chapter

Mortensen, H.B. (1994). Microalbuminuria in Young Patients with Type 1 Diabetes. In: Mogensen, C.E. (eds) The Kidney and Hypertension in Diabetes Mellitus. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6746-9_27

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-6746-9_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6748-3

  • Online ISBN: 978-1-4757-6746-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics