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Pathogenesis of Diabetic Glomerulopathy: The Role of Glomerular Hemodynamic Factors

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The Kidney and Hypertension in Diabetes Mellitus

Abstract

Glomerular hyperfiltration in insulin-dependent (type 1) diabetes mellitus (IDDM) has been recognized for many years [1–3], with increments in renal plasma flow (RPF) and nephromegaly [3]. With the finding of hyperfiltration, Stalder and Schmid proposed that these early functional changes may predispose the subsequent development of diabetic glomerulopathy [1]. Early support for the hypothesis that renal hyperperfusion and hyperfiltration contribute to diabetic glomerulopathy emanated from the finding of diabetic glomerulopathy only in the non-stenosed kidney in the setting of unilateral renal artery stenosis [4].

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Authors
  1. Jiten P. Vora
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  2. Sharon Anderson
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  3. Barry M. Brenner
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Editor information

Editors and Affiliations

  1. Medical Department M (Diabetes & Endocrinology) Aarhus Kommunehospital, University Hospitals in Aarhus, Aarhus C, Denmark

    Carl Erik Mogensen

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Vora, J.P., Anderson, S., Brenner, B.M. (1994). Pathogenesis of Diabetic Glomerulopathy: The Role of Glomerular Hemodynamic Factors. In: Mogensen, C.E. (eds) The Kidney and Hypertension in Diabetes Mellitus. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6746-9_22

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  • DOI: https://doi.org/10.1007/978-1-4757-6746-9_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6748-3

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