Albuminuria and Renal Disease in NIDDM-Patients

  • Anita Schmitz


The multitude of reports on the unequivocal importance of microalbuminuria in predicting diabetic complications in insulin-dependent diabetes (IDDM), have during recent years been succeeded by an increasing number of studies on patients with non-insulin-dependent diabetes (NIDDM). It has hence become clear, that the course of complications and the implication of microalbuminuria differ in several respects between the two types of diabetes [1–3].


Diabetic Nephropathy Urinary Albumin Excretion Diabetes Duration NIDDM Patient Large Vessel Disease 
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  1. 1.
    Mogensen CE, Schmitz O. The diabetic kidney: From hyperfiltration and microalbuminuria to end-stage renal failure. Med Clin North America 1988; 72: 1465–1492.Google Scholar
  2. 2.
    Mogensen CE, Damsgaard EM, Frøland A, Nielsen S, de Fine Olivarius N, Schmitz A: Microalbuminuria in non-insulin-dependent diabetes. Clin Nephrol 1992;38:s28–s38.Google Scholar
  3. 3.
    Schmitz, A. The kidney in non-insulin-dependent diabetes. Studies on glomerular structure and function and the relationship between microalbuminuria and mortality. Acta Diabetol Lat 1992; 29: 47–69.CrossRefGoogle Scholar
  4. 4.
    Fabre J, Balant LP, Dayer PG, Fox HM, Vernet AT. The kidney in maturity onset diabetes mellitus: A clinical study of 510 patients. Kidney Int 1982; 21: 730–738.PubMedCrossRefGoogle Scholar
  5. 5.
    Schmitz A, Væth M. Microalbuminuria: A major risk factor in non-insulin-dependent diabetes. A 10-year follow-up study of 503 patients. Diabetic Med 1988; 5: 126–134.PubMedCrossRefGoogle Scholar
  6. 6.
    Gall M-A, Rossing P, Skøøtt P, Damsbo P, Vaag A, Bech K, Dejgaard A, Lauritzen M, Lauritzen E, Hougaard P, Beck-Nielsen H, Parving H-H. Prevalence of micro- and macroalbuminuria, arterial hypertension, retinopathy and large vessel disease in European Type 2 (non-insulin-dependent) diabetic patients. Diabetologia 1991; 34: 655–661.PubMedCrossRefGoogle Scholar
  7. 7.
    Marshall SM, Alberti KGMM. Comparison of the prevalence and associated features of abnormal albumin excretion in insulin-dependent and non-insulin-dependent diabetes. Q J Med 1989; 70: 61–71.PubMedGoogle Scholar
  8. 8.
    Damsgaard EM. Prevalence and incidence of microalbuminuria in non-insulin-dependent diabetes: Relations to other vascular lesions. In: Mogensen CE (ed). The Kidney and Hypertension in Diabetes Mellitus. Boston: Martinus Nijhoff Publishing; 1988; pp 59–63.Google Scholar
  9. 9.
    Olivarius N de F, Andreasen AH, Keiding N, Mogensen CE. Epidemiology of renal involvement in newly-diagnosed middle-aged and elderly diabetic patients. Crosssectional data from the population-based study »Diabetes Care in General Practice«, Denmark. Diabetologia 1993; 36: 1007–1016.CrossRefGoogle Scholar
  10. 10.
    Standl E, Stiegler H. Microalbuminuria in a random cohort of recently diagnosed Type 2 (non-insulin-dependent) diabetic patients living in the Greater Munich Area. Diabetologia 1993; 36: 1017–1020.PubMedCrossRefGoogle Scholar
  11. 11.
    Ballard DJ, Humphrey LL, Melton LJ III, Frohnert PP, Chu C-P, O’Fallon WM, Palumbo Pi. Epidemiology of persistent proteinuria in type II diabetes mellitus. Population-based study in Rochester, Minnesota. Diabetes 1988; 37: 405–412.PubMedCrossRefGoogle Scholar
  12. 12.
    Schmitz A, Hvid Hansen H, Christensen T. Kidney function in newly diagnosed Type 2 (non-insulin dependent) diabetic patients, before and during treatment. Diabetologia 1989; 32: 434–439.PubMedCrossRefGoogle Scholar
  13. 13.
    Uusitupa M, Siitonen O, Penttilä I, Aro A, Pyörälä K. Proteinuria in newly diagnosed type II diabetic patients. Diabetes Care 1987; 10: 191–194.PubMedCrossRefGoogle Scholar
  14. 14.
    Martin P, Hampton KK, Walton C, Tindall H, Davies JA. Microproteinuria in Type 2 diabetes mellitus from diagnosis. Diabetic Med 1990; 7: 315–318.PubMedCrossRefGoogle Scholar
  15. 15.
    Patrick AW, Leslie PJ, Clarke BF, Frier BM. The natural history and associations of microalbuminuria in type 2 diabetes during the first year after diagnosis. Diabetic Med 1990; 7: 902–908.PubMedCrossRefGoogle Scholar
  16. 16.
    Tung P, Levin SR: Nephropathy in non-insulin-dependent diabetes mellitus. Am J Med 1988; 85: suppl. 5A: 131–136.PubMedCrossRefGoogle Scholar
  17. 17.
    Mauer SM, Chavers BM. A comparison of kidney disease in Type I and Type II diabetes. In: Vranic M, Hollenberg CH, Steiner G (eds). Comparison of Type I and Type II Diabetes. Similarities and dissimilarities in etiology, pathogenesis, and complications. New York: London; Plenum Press; 1985; pp 299–303.Google Scholar
  18. 18.
    Rosansky SI, Eggers PW. Trends in the US end-stage renal disease population: 19731983. Am J Kidney Dis 1987; 9: 91–97.PubMedGoogle Scholar
  19. 19.
    Brunner FP, Brynger H, Challah S, Fassbinder W, Geerlings W, Selwood NH, Tufveson G, Wing AJ. Renal replacement therapy in patients with diabetic nephropathy, 19801985. Report from the European Dialysis and Transplant Association Registry. Nephrol Dial Transplant 1988; 3: 585–595.PubMedGoogle Scholar
  20. 20.
    Jarrett RJ, Viberti GC, Argyropoulos A, Hill RD, Mahmud U, Murrells Ti. Microalbuminuria predicts mortality in non-insulin-dependent diabetes. Diabetic Med 1984; 1: 17–19.PubMedCrossRefGoogle Scholar
  21. 21.
    Mogensen CE. Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. N Engl J Medl 1984; 310: 356–360.CrossRefGoogle Scholar
  22. 22.
    Mogensen CE, Chachati A, Christensen CK, Close CF, Deckert T, Hommel E, Kastrup J, Lefebvre P, Mathiesen ER, Feldt-Rasmussen B, Schmitz A, Viberti GC. Microalbuminuria: an early marker of renal involvement in diabetes. Uremia Invest 1985–86; 9: 85–95.PubMedGoogle Scholar
  23. 23.
    Miles DW, Mogensen CE, Gundersen HJG. Radioimmunoassay for urinary albumin using a single antibody. Scand J Clin Lab Invest 1970; 26: 5–11.PubMedCrossRefGoogle Scholar
  24. 24.
    Mattock MB, Morrish NJ, Viberti GC, Keen H, Fitzgerald AP, Jackson G. Prospective study of microalbuminuria as predictor of mortality in NIDDM. Diabetes 1992; 41: 736–741.PubMedCrossRefGoogle Scholar
  25. 25.
    Damsgaard EM, Frøland A, Jørgensen OD, Mogensen CE. Eight to nine year mortality in known non-insulin dependent diabetics and controls. Kidney Int 1992; 41: 731–735.PubMedCrossRefGoogle Scholar
  26. 26.
    Neil A, Hawkins M, Potok M, Thorogood M, Cohen D, Mann J. A prospective population-based study of microalbuminuria as a predictor of mortality in NIDDM. Diabetes Care 1993; 16: 996–1003.PubMedCrossRefGoogle Scholar
  27. 27.
    Schmitz A. Renal function changes in middle-aged and elderly Caucasian Type 2 (noninsulin-dependent) diabetic patients — a review. Diabetologia 1993; 36:985–992.PubMedCrossRefGoogle Scholar
  28. 28.
    Damsgaard EM, Mogensen CE. Microalbuminuria in elderly hyperglycaemic patients and controls. Diabetic Med 1986; 3: 430–435.PubMedCrossRefGoogle Scholar
  29. 29.
    Hostetter TH, Rennke HG, Brenner BM. The case for intrarenal hypertension in the initiation and progression of diabetic and other glomerulopathies. Am J Med 1982; 72: 375–380.PubMedCrossRefGoogle Scholar
  30. 30.
    Schmitz A. Increased urinary haemoglobin in diabetics with microalbuminuria — measured by an ELISA. Scand J Clin Lab Invest 1990; 50: 303–308.PubMedCrossRefGoogle Scholar
  31. 31.
    Deckert T, Feldt-Rasmussen B, Borch-Johnsen K, Jensen T, Kofoed-Enevoldsen A. Albuminuria reflects widespread vascular damage. The Steno hypothesis. Diabetologia 1989; 32: 219–226.PubMedCrossRefGoogle Scholar
  32. 32.
    Mattock MB, Keen H, Viberti GC, El-Gohari MR, Murrells TJ, Scott GS, Wing JR, Jackson PG. Coronary heart disease and ur inary albumin excretion rate in type 2 (noninsulin-dependent) diabetic patients. Diabetologia 1988; 31: 82–87.PubMedCrossRefGoogle Scholar
  33. 33.
    Eiskjær H, Bagger JP, Mogensen CE, Schmitz A, Pedersen EB. Enhanced urinary excretion of albumin in congestive heart failure: effect of ACE-inhibition. Scand J Clin Lab Invest 1992; 52: 193–199.PubMedCrossRefGoogle Scholar
  34. 34.
    Kelbek H, Jensen T, Feldt-Rasmussen B, Christensen NJ, Richter EA, Deckert T, Nielsen SL. Impaired left-ventricular function in insulin-dependent diabetic patients with increased urinary albumin excretion. Scand J Clin Lab Invest 1991; 51: 467–473.CrossRefGoogle Scholar
  35. 35.
    Keen H. Macrovascular disease in diabetes mellitus. In: Andreani D, Crepaldi G, Di Mario U, Pozza G (eds). Diabetic Complications: Early Diagnosis and Treatment. John Wiley & Sons Ltd.; 1987; pp 3–12.Google Scholar
  36. 36.
    Jensen T. Albuminuria — a marker of renal and generalized vascular disease in insulindependent diabetes mellitus (thesis). København: Lægeforeningens Forlag; 1991.Google Scholar
  37. 37.
    Winocour PH, Durrington PN, Ishola M, Anderson DC, Cohen H. Influence of proteinuria on vascular disease, blood pressure, and lipoproteins in insulin dependent diabetes mellitus. BMJ 1987; 294: 1648–1651.PubMedCrossRefGoogle Scholar
  38. 38.
    Niskanen L, Uusitupa M, Sarlund H, Siitonen O, Voutilainen E, Penttilä I, Pyörälä K. Microalbuminuria predicts the development of serum lipoprotein abnormalities favouring atherogenesis in newly diagnosed Type 2 (non-insulin-dependent) diabetic patients. Diabetologia 1990; 33: 237–243.PubMedCrossRefGoogle Scholar
  39. 39.
    Standl E, Stiegler H, Janka HU, Mehnert H. Risk profile of macrovascular disease in diabetes mellitus. Diabete Metab (Paris) 1988; 14: 505–511.Google Scholar
  40. 40.
    Schmitz A, Ingerslev J. Haemostatic measures in Type 2 diabetic patients with microalbuminuria. Diabetic Med 1990; 7: 521–525.PubMedCrossRefGoogle Scholar
  41. 41.
    Stehouwer CDA, Nauta JJP, Zeldenrust GC, Hackeng WHL, Donker AJM, den Ottolander GJH. Urinary albumin excretion, cardiovascular disease, and endothelial dysfunction in non-insulin-dependent diabetes mellitus. Lancet 1992; 340: 319–323.PubMedCrossRefGoogle Scholar
  42. 42.
    Jensen T, Bjerre-Knudsen J, Feldt-Rasmussen B, Deckert T. Features of endothelial dysfunction in early diabetic nephropathy. Lancet 1989; i: 461–463.CrossRefGoogle Scholar
  43. 43.
    Gellman DD, Pirani CL, Soothill JF, Muehrcke RC, Kark RM. Diabetic nephropathy, a clinical and pathologic study based on renal biopsies. Medicine 1959; 38: 321–367.PubMedGoogle Scholar
  44. 44.
    Thomsen AC. The Kidney in Diabetes Mellitus (thesis). Copenhagen: Munksgaard; 1965.Google Scholar
  45. 45.
    Schmitz A, Gundersen HJG, østerby R. Glomerular morphology by light microscopy in non-insulin-dependent diabetes mellitus. Lack of glomerular hypertrophy. Diabetes 1988; 37: 38–43.PubMedCrossRefGoogle Scholar
  46. 46.
    Østerby R, Gall M-A, Schmitz A, Nielsen FS, Nyberg G, Parving H-H. Glomerular structure and function in proteinuric Type 2 (non-insulin-dependent) diabetic patients. Diabetologia 1993; 36: 1064–1070.PubMedCrossRefGoogle Scholar
  47. 47.
    Parving H-H, Gall M-A, Skøtt P, Jørgensen HE, Løkkegaard H, Jørgensen F, Nielsen B, Larsen S. Prevalence and causes of albuminuria in non-insulin-dependent diabetic patients. Kidney Int 1992; 41: 758–762.PubMedCrossRefGoogle Scholar
  48. 48.
    Taft JL, Billson VR, Nankervis A, Kincaid-Smith P, Martin FIR. A clinical-histological study of individuals with diabetes mellitus and proteinuria. Diabetic Med 1990; 7: 215–221.PubMedCrossRefGoogle Scholar
  49. 49.
    Keen H, Chlouverakis C, Fuller J, Jarrett RJ. The concomitants of raised blood sugar: studies in newly-detected hyperglycaemics. II: Urinary albumin excretion, blood pressure and their relation to blood sugar levels. Guys Hosp Rep 1969; 118: 247–254.PubMedGoogle Scholar
  50. 50.
    Ibsen H, Hilsen T. New views on the relationship between coronary heart disease and hypertension. J Intern Med 1990; 227: 77–79.PubMedCrossRefGoogle Scholar
  51. 51.
    Mogensen CE. Microalbuminuria as a predictor of clinical diabetic nephropathy. Kidney Int 1987; 31: 673–689.PubMedCrossRefGoogle Scholar
  52. 52.
    Humphrey LL, Ballard DJ, Frohnert PP, Chu C-P, O’Fallon WM, Palumbo PJ. Chronic renal failure in non-insulin-dependent diabetes mellitus. A population-based study in Rochester, Minnesota. Ann Intern Med 1989; 111: 788–796.PubMedCrossRefGoogle Scholar
  53. 53.
    Melbourne Diabetic Nephropathy Study Group. Comparison between perindopril and nifedipine in hypertensive and normotensive diabetic patients with microalbuminuria. BMJ 1991; 302: 210–216.CrossRefGoogle Scholar
  54. 54.
    Lacourcière Y, Nadeau A, Poirier L, Tancrède G. Captopril or conventional therapy in hypertensive type II diabetics. Three year analysis. Hypertension 1993; 21: 786–794.PubMedCrossRefGoogle Scholar
  55. 55.
    Ravid M, Savin H, Jutrin I, Bental T, Katz B, Lishner M. Long-term stabilizing effect of angiotensin-converting enzyme inhibition on plasma creatinine and on proteinuria in normotensive type II diabetic patients. Ann Intern Med 1993; 118: 577–581.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media New York 1994

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  • Anita Schmitz

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