Abstract
The dominant histological feature of diabetic nephropathy is the thickening of the glomerular basement membrane and expansion of the mesangial matrix [1–3]. The changes correlate strongly with the clinical onset of proteinuria, hypertension and kidney failure. Although more than 50 years have elapsed since Kimmelstiel and Wilson [4] described in diabetic glomeruli the distinctive periodic acid-schiff (PAS)-reactive nodular deposits, progress in elucidating the pathobiochemistry has been slow. Recent investigations with electron microscopic, immunochemical and biochemical methods have led to an improved understanding of the structure-function relationship of the glomerular filtration unit in normal and pathological conditions [5]
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Schleicher, E.D. (1994). Biochemical Aspects of Diabetic Nephropathy. In: Mogensen, C.E. (eds) The Kidney and Hypertension in Diabetes Mellitus. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6746-9_19
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DOI: https://doi.org/10.1007/978-1-4757-6746-9_19
Publisher Name: Springer, Boston, MA
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