Biochemical Aspects of Diabetic Nephropathy

  • Erwin D. Schleicher


The dominant histological feature of diabetic nephropathy is the thickening of the glomerular basement membrane and expansion of the mesangial matrix [1–3]. The changes correlate strongly with the clinical onset of proteinuria, hypertension and kidney failure. Although more than 50 years have elapsed since Kimmelstiel and Wilson [4] described in diabetic glomeruli the distinctive periodic acid-schiff (PAS)-reactive nodular deposits, progress in elucidating the pathobiochemistry has been slow. Recent investigations with electron microscopic, immunochemical and biochemical methods have led to an improved understanding of the structure-function relationship of the glomerular filtration unit in normal and pathological conditions [5]


Diabetic Nephropathy Heparan Sulfate Mesangial Cell Glomerular Basement Membrane Mesangial Matrix 
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© Springer Science+Business Media New York 1994

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  • Erwin D. Schleicher

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