Abstract

The singular importance of the brain to life is exemplified by agreement on medical, legal, and ethical grounds that a person dies when brain death occurs.1 Yet, the brain is highly vulnerable to a variety of insults such as stroke, cardiac arrest, trauma, near-drowning, carbon monoxide poisoning, etc. with high morbidity and mortality. Actual figures vary, but the mortality rate is about 50% for patients sustaining head injury2 or cardiac arrest.3 About 20% of survivors suffer moderate to severe neurological deficit.2–4 Each year, 0.05 to 0.12% of the U.S. population dies as a result of cerebrovascular disease.4 Thus, brain damage is a major public health problem deserving every effort towards understanding its pathogenesis and treatment.

Keywords

Brain Ischemia Global Ischemia Focal Ischemia Ischemic Brain Injury Global Brain Ischemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Edwin M. Nemoto
    • 1
  1. 1.Anesthesia and CCM Research Laboratories, Department of Anesthesiology and Critical Care MedicineUniversity of Pittsburgh School of MedicinePittsburghUSA

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