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Abstract

When acute renal failure (ARF) is severe, resolution can take several days or weeks. During this time, the kidneys cannot maintain homeostasis of fluid, potassium, metabolic acid, and waste products. Life-threatening complications inevitably develop. In these patients, extracorporeal techniques of blood purification must be applied to prevent such complications. These techniques, broadly named renal replacement therapies (RRT), include continuous hemofiltration (HF), intermittent hemodialysis (IHD), and peritoneal dialysis (PD). All of these techniques rely on the principle of removing unwanted solutes and water through a semipermeable membrane. This membrane is either biological (peritoneum) or artificial (hemodialysis or hemofiltration membranes), and each has advantages, disadvantages, and limitations.

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References

  1. Sargent J, Gotch F. Principles and biophysics of dialysis. In: Maher J, ed. Replacement of Renal Function by Dialysis: a textbook of dialysis. 3rd edtition. Dordrecht; Boston: Kluwer Academic Publishers, 1989: 87–102.

    Chapter  Google Scholar 

  2. Henderson L. Biophysics of ultrafiltration and hemofiltration. In: Maher J, ed. Replacement of Renal Function by Dialysis: a textbook of dialysis. 3rd edition. Dordrecht; Boston: Kluwer Academic Publishers, 1989, 300–32.

    Chapter  Google Scholar 

  3. Nolph KD. Peritoneal dialysis. In: Brenner BM, Rector FC, eds. The Kidney. First edition. Philadelphia: WB Saunders, 1986, 1791–845.

    Google Scholar 

  4. Conger JD. Does hemodialysis delay recovery from acute renal failure? Seminars Dial 1990; 3: 146–145.

    Article  Google Scholar 

  5. Howdieshell TR, Blalock WE, Bowen PA, Hawkins ML, Hess C. Management of post-traumatic acute renal failure with peritoneal dialysis. Am Surg 1992; 58: 378–82.

    PubMed  CAS  Google Scholar 

  6. Bellomo R, Boyce N. Continuous venovenous hemodiafiltration compared with conventional dialysis in critically ill patients with acute renal failure. ASAIO J 1993; 39: M794–7.

    Article  PubMed  CAS  Google Scholar 

  7. Gettings LG, Reynolds HN, Scalea T. Outcome in post-traumatic acute renal failure when continuous renal replacement therapy is applied early vs. late. Intensive Care Med 1999; 25: 805–13.

    Article  PubMed  CAS  Google Scholar 

  8. Chatoth DK, Shaver MJ, Marshall MR, Golper TA. Daily 12-hour sustained low-efficiency hemodialysis (SLED) for the treatment of critically ill patients with acute renal failure: Initial experience. Blood Purif 1999; 17: Abstract 16.

    Google Scholar 

  9. Paganini EP. Dialysis is not dialysis is not dialysis! Acute dialysis is different and needs help! Am J Kidney Dis 1998; 32: 832–3.

    Article  PubMed  CAS  Google Scholar 

  10. Bellomo R, Ronco C. Adequacy of dialysis in the acute renal failure of the critically ill: The case for continuous therapies. Int J Artif Organs 1996; 19: 129–42.

    PubMed  CAS  Google Scholar 

  11. Kanagasundaram NS, Paganini EP. Critical care dialysis–a Gordian knot (but is untying the right approach?). Nephrol Dial Transplant 1999; 14: 2590–4.

    Article  PubMed  CAS  Google Scholar 

  12. Mehta RL, Letteri JM. Current status of renal replacement therapy for acute renal failure. A survey of US nephrologists. The National Kidney Foundation Council on Dialysis. Am J Nephrol 1999; 19: 377–82.

    Article  PubMed  CAS  Google Scholar 

  13. Mehta R, Dobos GJ, Ward DM. Anticoagulation procedures in continuous renal replacement. Seminars Dial 1992; 5: 61–8.

    Article  Google Scholar 

  14. Bellomo R, Teede H, Boyce N. Anticoagulant regimens in acute continuous hemodiafiltration: a comparative study. Intensive Care Med 1993; 19: 329–32.

    Article  PubMed  CAS  Google Scholar 

  15. Hakim RM, Wingard RL, Parker RA. Effect of the dialysis membrane in the treatment of patients with acute renal failure. N Engl J Med 1994; 331: 1338–42.

    Article  PubMed  CAS  Google Scholar 

  16. Macias WL, Clark WR. Azotemia control by extracorporeal therapy in patients with acute renal failure. New Horiz 1995; 3: 688–98.

    PubMed  CAS  Google Scholar 

  17. Kierdorf HP. The nutritional management of acute renal failure in the intensive care unit. New Horiz 1995; 3: 699–707.

    PubMed  CAS  Google Scholar 

  18. Davenport A. The management of renal failure in patients at risk of cerebral edema/hypoxia. New Horiz 1995; 3: 717–24.

    PubMed  CAS  Google Scholar 

  19. Schiff] H, Lang SM, Konig A, Strasser T, Haider MC, Held E. Biocompatible membranes in acute renal failure: prospective case-controlled study. Lancet 1994; 344: 570–2.

    Google Scholar 

  20. Jones A, Gahl GM, Dobis C, Polenakovic MH, Cakalaroski K, Rutkowski B, Kisielnicka E, Krieter DH, Rumpf KW, Guenther C, Gaus W, Hoegel J. Haemodialysis-membrane biocompatibility and mortality of patients with dialysis-dependent acute renal failure: a prospective randomized multicentre trial. International Multicentre Study Group. Lancet 1999; 354: 1337–41.

    Article  Google Scholar 

  21. Vanholder R, Lemeire N. Does biocompatibility of dialysis membranes affect recovery of renal function and survival? Lancet 1999; 354: 1316–8.

    Article  PubMed  CAS  Google Scholar 

  22. Lameire N, Van Biesen W, Vanholder R. Dialysing the patient with acute renal failure in the ICU: the emperor’s clothes? Nephrol Dial Transplant 1999; 14: 2570–3.

    Article  PubMed  CAS  Google Scholar 

  23. Bellomo R. Continuous hemofiltration as blood purification in sepsis. New Horiz 1995; 3: 732–7.

    PubMed  CAS  Google Scholar 

  24. Tetta C, Mariano F, Ronco C, Bellomo R. Removal and generation of inflammatory mediators during continuous renal replacement therapies. In Ronco C, Bellomo R, eds. Crit Care Nephrology. Dordrecht; Boston: Kluwer Academic Publishers, 1998: 1239–48.

    Chapter  Google Scholar 

  25. Buckmaster J, Davies AR. Guidelines for drug dosing during continuous renal replacement therapies. In Ronco C, Bellomo R, eds. Crit Care Nephrology. Dordrecht; Boston: Kluwer Academic Publishers, 1998: 1327–34.

    Chapter  Google Scholar 

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© 2001 Springer Science+Business Media New York

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Bellomo, R., Ronco, C. (2001). Dialytic Therapy. In: O’Donnell, J.M., Nácul, F.E. (eds) Surgical Intensive Care Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6645-5_38

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  • DOI: https://doi.org/10.1007/978-1-4757-6645-5_38

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6647-9

  • Online ISBN: 978-1-4757-6645-5

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