Abstract
Fat embolism in humans was first recognized in 1861 by Zenker (1) who described fat droplets in the lung of a railroad worker who had suffered a fatal thoracoabdominal crush injury. Despite the patient’s multiple fractures, Zenker believed the fat to have originated from the contents of a lacerated stomach. Twelve years later, Von Bergmann (2) clinically diagnosed fat embolism syndrome (FES) in a patient with a fractured femur, and in 1875 Czerny (3) investigated the association of cerebral symptoms that sometimes occurred in patients with fat emboli. While most patients with FES are victims of trauma or have undergone orthopedic surgery, the entity has also been associated with a long list of medical conditions (Table 1).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Zenker FA. Beitrage zur Anatomie und Physiologie der Lunge. J Braundorf 1861.
Von Bergmann EB. Ein fall todlicher fettembolie. Klan Wochenschr 1873; 10: 385–7.
Czerny V. fiber die klinische bedeutung der fettembolie. Klan Wochenschr 1875; 12: 593.
Kent SR Fat embolism in diabetic patients without physical trauma. Am J Pathol 1955; 31: 399–403.
Katz DA, Ben-Ezra J, Factor SM, Houroupian DS, Goldfischer S. Fatal pulmonary and cerebral fat embolism in systemic lupus erythematosus. JAMA 1983; 250: 2666–9.
Emson HE. Fat embolism studied in 100 patients dying after injury. J Clin Pathol 1958; 11: 28–35.
Saada M, Trunet P, Bonnet F, Brun-Buisson C, Lange F, Lemaire F, Rapin M. Acute respiratory distress syndrome after lymphography. Ann Fr Anesth Reanim 1985; 4: 79–81.
Kitchell CC, Balogh K. Pulmonary lipid emboli in association with long term hyperalimentation. Hum Pathol 1986; 17: 83–5.
Rosen JM, Braman SS, Hasan FM, Teplitz C. Nontraumatic fat embolization. A rare cause of new pulmonary infiltrates in an immunocompromised patient. Am Rev Respir Dis 1986; 134: 805–8.
Broder G, Ruzumna L. Systemic fat embolism following acute primary osteomyelitis. JAMA 1967; 199: 150–2.
Jones MB. Pulmonary fat emboli associated with acute fatty liver of pregnancy. Am J Gastroenterol 1993; 88: 791–2.
Krischer JP, Fine EG, Davis JH, Nagel EL. Complications of cardiac resuscitation. Chest 1987; 92: 287–91.
Dines DE, Burgher LW, Okazaki H. The clinical and pathologic correlation of fat embolism syndrome. Mayo Clin Proc 1975; 50: 407–411.
Guardia SN, Bilbao JM, Murray D, Warren RE, Sweet J. Fat embolism in acute pancreatitis. Arch Pathol Lab Med 1989; 113: 503–6.
Levy D. The fat embolism syndrome. Clin Orthop 1990; 261: 281–6.
Shapiro MP, Hayes JA. Fat embolism in sickle cell disease. Report of a case with brief review of the literature. Arch Intern Med 1984; 144: 181–2.
Johnson M, Lucas GL. Fat embolism syndrome. Orthopedics 1996; 19: 41–9.
Baselga J, Reich L, Doherty M, Gulati S. Fat embolism syndrome following bone marrow harvesting. Bone Marrow Transplant 1991; 7: 485–6.
Laub DR Jr, Laub DR. Fat embolism syndrome after liposuction: A case report and review of the literature. Ann Plast Surg 1990; 25: 48–52.
Haymaker W, Davison C. Fatalities resulting from exposure to simulated high altitudes in decompression chambers; clinicopathologic study of 5 cases. J Neuropathol Exp Neurol 1950; 9: 29–59.
Capan LM, Miller SM, Patel KP. Fat embolism. Anesth Clin North Am 1993; 11: 25–54.
Menendez LR, Bacon W, Kempf RA, Moore TM. Fat embolism syndrome complicating intraarterial chemotherapy with cis-platinum. Clin Orthop 1990; 254: 294–7.
Durlacher SH, Meier JR, Fisher RS, Lovitt WV. Sudden death due to pulmonary fat embolism in persons with alcoholic fatty liver. Am J Pathol 1954; 30: 633–4.
Chastre J, Basset F, Viau F, Dournovo P, Bouchama A, Akesbi A, Gibert C. Acute pneumonitis after subcutaneous injections of silicone in transsexual men. N Engl J Med 1983; 308: 764–7.
Bloch B. Fatal fat embolism following severe donkey bites. J Forensic Sci Soc 1976; 16: 231–3.
Sevitt S. The significance and pathology of fat embolism. Ann Clin Res 1977; 9: 173–80.
Lindeque BG, Schoeman HS, Dommisse GF, Boeyens MC, Vlok AI. Fat embolism and the fat embolism syndrome. A double blind therapeutic study. J Bone Joint Surg Br 1987; 69: 128–31.
Scully RE. Fat embolism in Korean battle causalities: its incidence, clinical significance, and pathologic aspects. Am J Pathol 1956; 32: 379–403.
Fuschig P, Brucke P, Blume! G, Gottlob R. A new clinical and experimental concept on fat embolism. N Engl J Med 1967; 276: 1192–3.
Peltier LF, Collins JA, Evarts CM, Sevitt S. A panel by correspondence. Fat embolism. Arch Surg 1974; 109: 12–16.
tenDuis HJ, Nijsten MW, Klasen HJ, Binnendijk B. Fat embolism in patients with an isolated fracture of the femoral shaft. J Trauma 1988; 28: 383–90.
Gossling HR, Pellegrini VD Jr. Fat embolism syndrome: a review of the pathophysiology and physiological basis of treatment. Clin Orthop 1982; 165: 68–82.
Morton KS, Kendall MJ. Fat embolism: its production and source of fat. Can J Surg 1965; 31: 214–20.
Jacobson DM, Terrence CF, Reimuth OM. The neurologic manifestations of fat embolism. Neurology 1986; 36: 847–51.
Hulman G. The pathogenesis of fat embolism. J Pathol 1995; 176: 3–9.
Bane P, Minnear FL, Malik AB. Increased pulmonary vascular permeability after bone marrow injection in sheep. Am Rev Respir Dis 1981; 123: 648–53.
Lequire VS, Shapiro JL, Lequire CB, Cobb CA Jr, Fleet WF Jr. A study of the pathogenesis of fat embolism based on human necropsy material and animal experiments. Am J Pathol 1959; 35: 999–1015.
Peltier LF. Fat embolism. 1H. The toxic properties of neutral fat and free fatty acids. Surgery 1956; 40: 665–70.
Byrick RJ, Mullen JB, Mazer CD, Guest CB. Transpulmonary systemic fat embolism. Studies in mongrel dogs after cemented arthroplasty. Am J Respir Crit Care Med 1994; 150: 1416–22.
Kamenar E, Burger PC. Cerebral fat embolism: a neuropathological study of a microembolic state. Stroke 1980; 11: 477–84.
KawanoY, Ochi M, Hayashi K, Morikawa M, Kimura S. Magnetic resonance imaging of cerebral fat embolism. Neuroradiology 1991; 33: 72–4.
Case Records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 23–1998. Tachypnea, changed mental status, and pancytopenia in an elderly man with treated lymphoma. N Engl J Med 1998; 39: 254–61.
Kaplan RP, Grant JN, Kaufman M. Dermatologie features of the fat embolism. Cutis 1986; 38: 52–5.
Muller C, Rahn BA, Pfister U, Meinig RP. The incidence, pathogenesis, diagnosis and treatment of fat embolism. Orthop Rev 1994; 23: 107–7.
Bulger EM, Smith DG, Maier RV, Jurkovich GJ. Fat embolism syndrome. A 10-year review. Arch Surg 1997; 132: 435–9.
Sevitt S. The significance and classification of fat embolism. Lancet 1960; 2: 825–8.
Gurd AR, Wilson RI. The fat embolism syndrome. J Bone Joint Surg Br 1974; 56: 408–16.
Bardana D, Rudan J, Cervenko F, Smith R. Fat embolism syndrome in a patient demonstrating only neurologic symptoms. Can J Surg 1998; 41: 398–402.
Pellegrini VD, Reid JS, Evarts CM. Fat embolism syndrome/acute respiratory distress syndrome. In: Rockwood CA, Green DP, Bucholz RW, Heckman JD, eds. Rockwood and Green’s Fractures in Adults. Vol 1. Philadelphia: Lippincott-Raven, 1996; 433–43.
Roden D, Fitzpatrick G, O’Donoghue H, Phelan D. Purtscher’s retinopathy and fat embolism. Br J Ophthahnol 1989; 73: 677–9.
Schnaid g Lamprey JM, Viljoen MJ, Joffe BI, Seftel HC. The early biochemical and hormonal profile of patients with long bone fractures at risk of fat embolism syndrome. J Trauma 1987; 27: 309–11.
Schwartz DA, Finkelstein SD, Lumb GD. Fat embolism to the cardiac conduction system associated with sudden death. Hum Pathol 1988; 19: 116–9.
Feldman F, Ellis K, Green WM. The fat embolism syndrome. Radiology 1975; 114: 535–42.
Lull RJ, Tatum JL, Sugerman HJ, Hartshorne MF, Boll DA, Kaplan KA. Radionuclide evaluation of lung trauma. Semin Nucl Med 1983; 13: 223–37.
Park HM, Ducret RP, Brindley DC. Pulmonary imaging in fat embolism syndrome. Clin Nucl Med 1986; 11: 521–2.
Skarzynski JJ, Stavin JD Jr, Spencer RP, Karimeddini MK. “Matching” ventilation/perfusion images in fat embolization. Clin Nucl Med 1986; 11: 40–1.
Lindeque BGP, Schoeman HS, Dommisse GF, Boeyens MC, Vlok AI. Fat embolism and the fat embolism syndrome. A double-blind therapeutic study. J Bone Joint Surg Br 1987; 69: 128–31.
Schonfeld SA, Polysongsang Y, DiLisio R, Crissman JD, Miller E, Hammerschmidt DE. Fat embolism prophylaxis with corticosteroids. A prospective study in high risk patients. Ann Intern Med 1983; 99: 438–43.
Treugut H, Zieger M, Weiske R. Differential diagnosis of posttraumatic pulmonary infiltrates. Radiologe 1986; 26: 21–6.
Chastre J, Fagon JY, Soler P, Fichelle A, Dombret MC, Huten D, Hance AJ, Gibert C. Bronchoalveolar lavage for rapid diagnosis of the fat embolism syndrome in the trauma patients. Ann Intern Med 1990; 113: 583–8.
Vedrinne JM, Guillaume C, Gagnieu MC, Gratadour P, Fleuret C, Motin J. Bronchoalveolar lavage in trauma patients for the diagnosis of fat embolism syndrome. Chest 1992; 102: 1323–7.
Stanley JD, Hanson RR, Hicklin GA, Glazier AJ Jr, Ervanian A, Jadali M. Specificity of bronchoalveolar lavage for the diagnosis of fat embolism syndrome. Am Surg 1994; 60: 537–41.
Gitin TA, Seidel T, Cera PJ, Glidewell OJ, Smith JL. Pulmonary microvascular fat: the significance? Crit Care Med 1993; 21: 673–7.
Stoeger A, Daniaux M, Felber S, Stockhammer G, Aichner F, zurNedden D. MRI findings in cerebral fat embolism. Eur Radiol 1998; 8: 1590–3.
Pell AC, Christie J, Keating JF, Sutherland GR. The detection of fat embolism by transesophageal echocardiography during reamed intramedullary nailing. A study of 24 patients with femoral and tibial fractures. J Bone Joint Surg Br 1993; 75: 921–5.
Bruecke P, Burke JF, Lam KW, Shannon DC, Kazemi H. The pathophysiology of pulmonary fat embolism. J Thorac Cardiovasc Surg 1971; 61: 949–55.
Hannan JW, Ragaz FJ. The pathogenesis of experimental fat embolism. Am J Pathol 1950; 26: 551–63.
Cotev S, Rosenmann E, Eyal Z. The role of hypovolemic stress in the production of fat embolism in rabbits. 1. Morphologic alterations of the lungs. Chest 1976; 69: 523–8.
Henderson SA, Graham HK, Mollan RA. Serum and other calcium fractions in patients after severe musculoskeletal trauma. Clin Orthop 1992; 275: 306–11.
Nixon JR, Brock-Utne JG. Free fatty acid and arterial oxygen changes following major injury: a correlation between hypoxemia and increased free fatty acid levels. J Trauma 1978; 18: 23–6.
Myers R, Taljaard JJ. Blood alcohol and fat embolism syndrome. J Bone Joint Surg Am 1977; 59: 878–80.
Allardyce DB. The adverse effect of heparin in experimental fat embolism. Surg Forum 1971; 22: 203–5.
Sari A, Migauchi Y, Yamashita S, Yokota K, Ogasahara H, Yonei A. The magnitude of hypoxemia in the elderly patients with fractures of the femoral neck. Anesth Analg 1986; 65: 892–4.
Ashbaugh DG, Petty TL. The use of corticosteroids in the treatment of respiratory failure associated with massive fat embolism. Surg Gynecol Obstet 1966; 123: 493–500.
Alho A, Saikku K, Eerola P, Koskinen M, Hamalainen M. Corticosteroids in patients with a high risk of fat embolism syndrome. Surg Gynecol Obstet 1978; 147: 358–62.
Kallenbach MB, Lewis M, Zaltzman M, Feldman C, Orford A, Zwi S. ‘Low-dose’ corticosteroid prophylaxis against fat embolism. J Trauma 1987; 27: 1173–6.
Shier MR, Wilson RF, James RE, Riddle J, Manmen EF, Pedersen HE. Fat embolism prophylaxis: a study of four treatment modalities. J Trauma 1977; 17: 621–9.
Johnson KD, Cadambi A, Seibert GB. Incidence of adult respiratory distress syndrome in patients with multiple musculoskeletal injuries: effects of early operative stabilization of fractures. J Trauma 1985; 25: 375–84.
Bone LB, Johnson KD, Weigelt J, Scheinberg R. Early versus delayed stabilization of femoral fractures. A prospective randomized study. J Bone Joint Surg Am 1989; 71: 336–40.
Pape HC, Auf m’Kolk M, Paffrath T, Regel G, Sturm JA, Tscheme H. Primary intramedullary femur fixation in multiple trauma patients with associated lung contusion: a cause of post traumatic ARDS? J Trauma 1993; 34: 540–8.
Hofmann S, Huemer G, Salzer M. Pathophysiology and management of the fat embolism syndrome. Anaesthesia 1998; 53 (Suppl 2): 35–7.
Moylan JA, Birnbaum M, Katz A, Everson MA. Fat emboli syndrome. J Trauma 1976; 16: 341–7.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer Science+Business Media New York
About this chapter
Cite this chapter
O’Donnell, J.M. (2001). Fat Embolism Syndrome. In: O’Donnell, J.M., Nácul, F.E. (eds) Surgical Intensive Care Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6645-5_23
Download citation
DOI: https://doi.org/10.1007/978-1-4757-6645-5_23
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-6647-9
Online ISBN: 978-1-4757-6645-5
eBook Packages: Springer Book Archive