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Immunosuppression and Treatment of Rejection

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Suki and Massry’s THERAPY OF RENAL DISEASES AND RELATED DISORDERS

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Abstract

The introduction in the 1980s of cyclosporine and monoclonal antibodies represented a major therapeutic advance in solid organ transplantation. The United Network for Organ Sharing (UNOS) has recently released the 1- and 2-year graft and patient survival rates for solid organ transplants (1). These survival rates are illustrated in Table 1. Currently, there are a number of promising new immunosuppressive agents on the horizon, and it appears likely that further advances will be made in our ability to control the immune response (2,3). A dynamic interaction exists between basic immunology and clinical transplantation. Advances in immunobiology have resulted in a better understanding of the immunological events involved in the recognition of and response to transplant antigens and have led to a better understanding of the action of various immunosuppressive agents. This chapter reviews the mechanisms involved in the immune response, how currently used immunosuppressive agents act, the possible role for future immunosuppressive drugs, the current approach to clinical immunosuppressive therapy, and the diagnosis and treatment of acute rejection.

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  1. Division of Nephrology and Hypertension, University of Cincinnati Medical Center, Cincinnati, OH, 45267-0585, USA

    M. Roy First M.D. (Professor of Medicine)

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Wadi N. Suki M.D. Shaul G. Massry M.D.

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First, M.R. (1998). Immunosuppression and Treatment of Rejection. In: Suki, W.N., Massry, S.G. (eds) Suki and Massry’s THERAPY OF RENAL DISEASES AND RELATED DISORDERS. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6632-5_65

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  • DOI: https://doi.org/10.1007/978-1-4757-6632-5_65

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