Disorders of Magnesium Homeostasis and Magnesium in Therapy

  • Jack W. Coburn
  • Barton S. Levine


Magnesium, atomic weight 24.3, is the fourth most abun­dant metal in living organisms; next to potassium, it is the most prevalent intracellular cation. Magnesium is abun­dant in all living organisms. In plants, magnesium occupies a position in chlorophyll that is somewhat analogous to that of iron in hemoglobin. In animals, magnesium is criti­cal for vast numbers of metabolic processes, including the production and utilization of energy. Magnesium held a dominant position in the oceans of the Precambrian era, a time when life is believed to have evolved. This fact may account for importance of Mg in a multitude of intracellu­lar processes; for example, Mg is a cofactor in almost every step of anaerobic glycolysis, a very primitive pathway in energy metabolism.


Fractional Excretion Magnesium Deficiency Thick Ascend Limb Advanced Renal Failure Urinary Magnesium 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Jack W. Coburn
    • 1
  • Barton S. Levine
    • 2
  1. 1.The Medical and Research Services Veterans Affairs Medical Center, West Los Angeles (Wadsworth Division) Department of MedicineNephrology Section (W111L) UCLA School of MedicineLos AngelesUSA
  2. 2.The Medical and Research Services Veterans Affairs Medical Center, West Los Angeles (Wadsworth Division) The Department of MedicineNephrology Section (W111L) UCLA School of MedicineLos AngelesUSA

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