Disorders of Calcium Metabolism

  • Theresa A. Guise
  • Gregory R. Mundy


The extracellular fluid (or plasma) calcium concentration is tightly controlled by a complex homeostatic mechanism involving fluxes of calcium across the kidney, bone, and gut. These fluxes are regulated by three major hormones: parathyroid hormone (PTH), calcitonin, and 1,25dihydroxyvitamin D (1,25(OH)2D3). Important cellular functions, such as those listed in Table 1, are dependent on the maintenance of the extracellular calcium concentration within a narrow range (1). Disruption of this finely tuned system results in disorders of calcium metabolism that have predictable effects on these essential physiologic functions and result in the signs and symptoms associated with hypercalcemia and hypocalcemia.


Parathyroid Gland Primary Hyperparathyroidism Parathyroid Adenoma Parathyroid Carcinoma Osteoclastic Bone Resorption 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Theresa A. Guise
    • 1
  • Gregory R. Mundy
    • 2
  1. 1.Division of EndocrinologyUniversity of Texas Health Science Center at San AntonioSan AntonioUSA
  2. 2.Department of MedicineUniversity of Texas Health Science Center at San AntonioSan AntonioUSA

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