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Prevention of Progression of Renal Disease

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Suki and Massry’s THERAPY OF RENAL DISEASES AND RELATED DISORDERS

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Abstract

In most forms of chronic renal disease, glomerular filtration rate (GFR) tends to decrease inexorably once a certain threshold of nephron destruction has occurred. The progressive decrease in GFR is accompanied histologically by increasing glomerulosclerosis and interstitial fibrosis, in which specialized segments of the nephron are progressively replaced by extracellular matrix (1). Renal diseases of diverse etiology culminate in nephrosclerosis, the hallmark of the end-stage diseased kidney. This suggests that a heterogenous array of initial insults can induce pathologic responses that converge upon a common avenue in which normal renal tissue is replaced by nonfunctional elements.

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Authors and Affiliations

  1. Department of Medicine, Washington University School of Medicine, The Jewish Hospital of St. Louis, St. Louis, MO, 63110, USA

    Saulo Klahr M.D. (Simon Professor of Medicine and Co-Chairman, Physician-in-Chief)

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  1. Saulo Klahr M.D.
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Wadi N. Suki M.D. Shaul G. Massry M.D.

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Klahr, S. (1998). Prevention of Progression of Renal Disease. In: Suki, W.N., Massry, S.G. (eds) Suki and Massry’s THERAPY OF RENAL DISEASES AND RELATED DISORDERS. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6632-5_45

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  • DOI: https://doi.org/10.1007/978-1-4757-6632-5_45

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6634-9

  • Online ISBN: 978-1-4757-6632-5

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