Renal Complications of Pregnancy

  • John M. Davison
  • Adrian I. Katz
  • Marshall D. Lindheimer


A clinician may be consulted on the advisability of conception or continuing a pregnancy in women with renal problems, and advice is too often based on anecdotal clinical experience. To give sound advice, the clinician must appreciate that a pregnant woman is physiologically different from a nonpregnant individual, and that during pregnancy there are progressive changes in the renal system that must be understood if we are to detect, diagnose, and manage problems.


Acute Renal Failure Obstet Gynecol Disseminate Intravascular Coagulum Hemolytic Uremic Syndrome Autosomal Dominant Polycystic Kidney Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Bailey RR, Rolleston GL: Kidney length and ureteric dilatation in the puerperium. J Obstet Gynaecol Br Commonw 78: 55–61, 1971.PubMedCrossRefGoogle Scholar
  2. 2.
    Rasmussen PE, Nielsen FR: Hydronephrosis during pregnancy: a literature review. Eur J Obstet Gynecol 27: 249–259, 1988.CrossRefGoogle Scholar
  3. 3.
    Brown MA: Urinary tract dilatation in pregnancy. Am J Obstet Gynecol 164: 641–643, 1990.Google Scholar
  4. 4.
    Satin AJ, Seikin GL, Cunningham FG: Reversible hypertension in pregnancy caused by obstructive uropathy. Obstet Gynecol 81: 823–825, 1993.PubMedGoogle Scholar
  5. 5.
    Davison JM, Noble MCB: Serial changes in 24-hour creati-nine clearance during normal menstrual cycles and the first trimester of pregnancy. Br Obstet Gynaecol 88: 10–17, 1981.CrossRefGoogle Scholar
  6. 6.
    Davison JM, Hytter FE: Glomerular filtration during and after pregnancy. Br J Obstet Gyneacol 81: 588–589, 1974.CrossRefGoogle Scholar
  7. 7.
    Dunlop W: Serial changes in renal haemodynamics during normal human pregnancy. BrJ Obstet Gynaecol 88: 1–9, 1981.CrossRefGoogle Scholar
  8. 8.
    Baylis C: Glomerular filtration and volume regulation in gravid animal models. Clin Obstet Gynaecol (Bailliere) 8: 235–264, 1994.CrossRefGoogle Scholar
  9. 9.
    Roberts M, Lindheimer MD, Davison JM: Alterations in glomerular permselecivity to neutral dextrans and heteroporous membrane modelling in human pregnancy. Am J Physiol 270: F338 - F343, 1996.PubMedGoogle Scholar
  10. 10.
    Davison JM, Dunlop W, Ezimokhai M: Twenty-four hour creatinine clearance during the third trimester of normal pregnancy. Br J Obstet Gynaecol 87: 106–109, 1980.PubMedCrossRefGoogle Scholar
  11. 11.
    Kuhlback B, Widelm O: Plasma creatinine in normal pregnancy. Scan J Clin Lab Invest 18: 654–658, 1966.CrossRefGoogle Scholar
  12. 12.
    Umans JA, Lindheimer MD: The renal adaptation to pregnancy is now nostalgic. J Clin Invest 96 (1): 482–490, 1995.CrossRefGoogle Scholar
  13. 13.
    Shurgiss SN, Dunlop W, Davison JM: Renal haemodynamics and tubular function in human pregnancy. Clin Obstet Gynaecol 8: 209–234, 1994.Google Scholar
  14. 14.
    Dunlop W, Davison JM: Renal haemodynamics and tubular function in human pregnancy. Clin Obstet Gynecol (Bailliere) 1: 769–786, 1987.CrossRefGoogle Scholar
  15. 15.
    Higby K, Suiter CR, Phelps JY, et al.: Normal values of urinary albumin and total protein excretion during pregnancy. Am J Obstet Gynecol 171: 984–989, 1994.PubMedCrossRefGoogle Scholar
  16. 16.
    Lindheimer MD, Katz AI: The normal and diseased kidney in pregnancy. In: RW Schrier, CW Gottischalk, eds, Diseases of the Kidney,6th ed. Little, Brown, Boston, in press.Google Scholar
  17. 17.
    Chesley LC: In: Hypertensive Disorders in Pregnancy. Appleton-Century-Crofts, New York, 1978.Google Scholar
  18. 18.
    Brown M, Gallery EDM: Volume homeostasis in normal pregnancy and preeclampsia: physiology and clinical implications. Clin Obstet Gynaecol 8: 281–310, 1994.Google Scholar
  19. 19.
    Gibson HM: Plasma volume and glomerular filtration rate in pregnancy and their relationship to fetal growth. J Obstet Gynaecol Br Commonw 80: 1067–1074, 1973.PubMedCrossRefGoogle Scholar
  20. 20.
    Cunningham FG, Lucas MJ: Urinary tract infections complicating pregnancy. Clin Obstet Gynaecol (Balliere) 8: 353–373, 1994.CrossRefGoogle Scholar
  21. 21.
    Bint AJ, Hill D: Bacteriuria of pregnancy-an update on significance, diagnosis, and management. J Antimicrob ChemoTher 33 (Suppl A): 93–97, 1994.PubMedCrossRefGoogle Scholar
  22. 22.
    McFadyen IR, Eykyn SJ, Gardner NHN, Vanier TM, Bennett AE, Mayo ME, Lloyd-Davis RW: Bacteriuria of pregnancy. J Obstet Gynaecol Br 80: 385–405, 1973.CrossRefGoogle Scholar
  23. 23.
    Lindheimer MD, Katz AI: Kidney disease in pregnancy, In: Kidney Function and Disease in Pregnancy. Lea and Febiger, Philadelphia, pp 106–145, 1977.Google Scholar
  24. 24.
    Kunin CM: The natural history of recurrent bacteriuria in schoolgirls. N Engl J Med 282: 1443–1448, 1970.PubMedCrossRefGoogle Scholar
  25. 25.
    Whalley PJ: Bacteriuria of pregnancy. Am J Obstet Gynecol 97: 723–738, 1967.PubMedGoogle Scholar
  26. 26.
    Stenquist K, Dahlin-Nilsson I, Lidin-Janson G: Bacteriuria in pregnancy. Frequency and risk of acquisition. Am J Epidemiol 129: 372–379, 1989.Google Scholar
  27. 27.
    Roark ML: Renal infection and pregnancy outcome. Am J Obstet Gynaecol 141: 709–716, 1981.Google Scholar
  28. 28.
    Condie AP, Brumfitt W, Reeves DS, William JD: The effects of bacteriuria in pregnancy on fetal health. In: W Brumfitt, AW Asscher, eds, Urinary Tract Infection. Oxford University Press, London, pp 108–116, 1973.Google Scholar
  29. 29.
    Davison JM, Sprott MS, Selkon JB: The effect of covert bacteriuria in schoolgirls on renal function at 18 years and during pregnancy. Lancet 2: 652–655, 1984.Google Scholar
  30. 30.
    Sacks SH, Verrier-Jones K, Roberts R, Asscher AW, Ledingham JGG: Effect of symptomless bacteriuria in childhood on subsequent pregnancy. Lancet 2: 991–994, 1987.PubMedCrossRefGoogle Scholar
  31. 31.
    Romero R, Oyarzum E, Mazor M, et al.: Meta-analysis of relationship between asymptomatic bacteriuria and preterm delivery/low birth weight babies. Obstet Gynecol 72: 576–582, 1989.Google Scholar
  32. 32.
    McGladdery SL, Aparicio S, Verrier-Jones K: Outcome of pregnancy in an Oxford/Cardiff cohort of women with previous bacteriuria. Q J Med 303: 533–539, 1992.Google Scholar
  33. 33.
    Graham JM, Oshiro BT, Blanco JD: Uterine contractions after antibiotic therapy for pyelonephritis in pregnancy. Am J Obstet Gynecol 168:577–580, 1993.Google Scholar
  34. 34.
    Lawson DH, Miller AWF: Screening for bacteriuria in pregnancy: a critical reappraisal. Arch Intern Med 132: 925–928, 1973.CrossRefGoogle Scholar
  35. 35.
    Chng PK, Hall MH: Antenatal eradication of urinary tract infection in pregnancy. Br J Obstet Gynaecol 89: 8–11, 1982.PubMedCrossRefGoogle Scholar
  36. 36.
    Campbell-Brown M, McFadyen IR, Seal DV, Stephenson ML: Is screening for bacteriuria in pregnancy worthwhile? Br Med J 294: 1579–1582, 1987.CrossRefGoogle Scholar
  37. 37.
    Pedler SJ, Orr KE: Bacterial, fungal and parasitic infections. In: WM Barron, MD Lindheimer, eds, Medical Disorders During Pregnancy, 2nd ed. Mosby, St. Louis, pp 356–388, 1995.Google Scholar
  38. 38.
    Zinner SH: Management of urinary tract infection associated with acute pyelonephritis of pregnancy. Obstet Gynecol 46: 174–180, 1992.Google Scholar
  39. 39.
    Pfau A, Sacks TG: Effective prophylaxis for recurrent urinary tract infections during pregnancy. Clin Infect Dis 14: 810–814, 1992.PubMedCrossRefGoogle Scholar
  40. 40.
    Gower PE, Haswell B, Sidaway ME, de Wardener HE: Follow-up of 164 patients with bacteriuria of pregnancy. Lancet 1: 990–994, 1968.CrossRefGoogle Scholar
  41. 41.
    Briedahl P, Hurst PE, Martin JD, Vivian AB: The postpartum investigation of pregnancy bacteriuria. Med J Aust 2: 1174–1177, 1972.Google Scholar
  42. 42.
    Pruett K, Faro S: Pyelonephritis associated with respiratory distress. Obstet Gynecol 69: 444–446, 1987.PubMedGoogle Scholar
  43. 43.
    Weinberger SE: Recent advances in pulmonary medicine. N Engl J Med 328: 1462–1470, 1993.PubMedCrossRefGoogle Scholar
  44. 44.
    Twickler DM, Lucas MJ, Bowe L, et al.: Ultrasonic evaluation of central and end-organ hemodynamics in antepartum pyelonephritis. Am J Obstet Gynecol 170: 814818, 1994.Google Scholar
  45. 45.
    Whalley PJ, Cunningham FG, Martin FG: Transient renal dysfunction associated with acute pyelonephritis of pregnancy. Obstet Gynecol 46: 174–179, 1975.PubMedGoogle Scholar
  46. 46.
    Sanchez-Ramos L, McAlpine KJ, Adair D, Kaunitz AM, Delke I, Briones DK: Pyelonephritis in pregnancy: once-aday ceftriaxone versus multiple doses of cefazolin. Am J Obstet Gynecol 172: 129–133, 1995.PubMedCrossRefGoogle Scholar
  47. 47.
    Meyers SJ, Lee RV, Munchauer RW: Dilation and non-traumatic rupture of the urinary tract during pregnancy: a review. Obstet Gynecol 66: 809–815, 1983.Google Scholar
  48. 48.
    Grunfeld JP, Pertuiset N: Acute renal failure in pregnancies. Am J Kidney Dis 9: 359–362, 1987.PubMedGoogle Scholar
  49. 49.
    Lindheimer MD, Katz AI, Ganeval D, Grunfeld JP: Renal failure in pregnancy. In: Acute renal failure BM Brenner, JH Lazarus, eds, 3rd ed. Churchill-Livingstone, New York, pp 417–439, 1993.Google Scholar
  50. 50.
    Pertuiset N, Grunfeld J-P: Acute renal failure in pregnancy. Clin Obstet Gynaecol (Balliere) 8: 333–351, 1994.CrossRefGoogle Scholar
  51. 51.
    Krane K, Cucuzzella A: Acute renal insufficiency in pregnancy: a review of 30 cases. J Mat Fet Med 4: 12–18, 1995.Google Scholar
  52. 52.
    Miller RB, Tassitro CR: Peritoneal dialysis. N Engl J Med 281: 945–947, 1969.PubMedCrossRefGoogle Scholar
  53. 53.
    Hou S: Peritoneal and hemodialysis in pregnancy. Clin Obstet Gynaecol (Balliere) 8: 481–500, 1994.CrossRefGoogle Scholar
  54. 54.
    Chugh KS, Singhal PC, Sharma BK, Pal Y, Mathew MT, Dhall K, Data BN: Acute renal failure of obstetrics origin. Obstet Gynecol 48: 642–646, 1976.PubMedGoogle Scholar
  55. 55.
    Richet G, Alagille D: La proteolyse precoce au course anuries hemolytiques du postabortum. Rev Fran Clin Biol 2: 475–479, 1975.Google Scholar
  56. 56.
    Hawkins OF, Sevitt LH, Fairbrother PF, Tothil AU: Management of chemical septic abortion with renal failure, use of conservative regimen. N Engl J Med 292: 722–725, 1975.PubMedCrossRefGoogle Scholar
  57. 57.
    Bartlett RH, Yahia C: Management of septic abortion, with renal failure: report of five consecutive cases in five survivors. N Engl J Med 281: 747–750, 1969.PubMedCrossRefGoogle Scholar
  58. 58.
    Hanson, GC: Shock and infection. In: GC Hanson, eds, The Medical Management of the Critically Ill. Academic Press, London, pp 367–373, 1978.Google Scholar
  59. 59.
    Sibai BM, Ramadan M: Acute renal failure in pregnancies complicated by hemolysis, elevated enzymes and low platelets. Am J Obstet Gynecol 168: 1682–1687, 1993.PubMedCrossRefGoogle Scholar
  60. 60.
    Sibai BM, Kustermann L, Velasco J: Current understanding of severe preeclampsia, pregnancy-associated hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, hemolysis elevated liver enzymes, and low platelet syndrome, and postpartum acute renal failure: different clinical syndromes or just different names? Curr Opinion Nephrol Hypertens 3: 436–445, 1994.CrossRefGoogle Scholar
  61. 61.
    Fisher K, Luger A, Spargo BH, Lindheimer MD: Hypertension in pregnancy: clinical-pathological correlation and remote prognosis. Medicine (Baltimore) 60: 267–274, 1981.Google Scholar
  62. 62.
    Gaber LW, Spargo BH, Lindheimer MD: Renal pathology in preeclampsia. Clin Obstet Gynaecol (Balliere) 8: 443–468, 1994.Google Scholar
  63. 63.
    Petersson C, Hedges S, Stangnuist K, et al.: Suppressed antibody and interleukin-6 response to acute pyelonephritis in pregnancy. Kidney Int 45: 571–577, 1994.PubMedCrossRefGoogle Scholar
  64. 64.
    Sheehan H: The pathology of acute yellow atrophy delayed chloroform poisoning. J Obstet Gynaecol Br Empine 47–56, 1940.Google Scholar
  65. 65.
    Weber FL, Snodgrass PJ, Powell DE, Rao P, Hoffman Brady RG: Abnormalities of hepatic mitochrondrial urea-cycle enzyme activities and hepatic ultrastructure in acute fatty liver of pregnancy. J Lab Clin Med 94 (1): 27–41, 1979.PubMedGoogle Scholar
  66. 66.
    Reye RDK, Morgan G, Banal J: Encephalopathy and degenertion of the viscera. A disease entity in children. Lancet 2: 749–752, 1963.PubMedCrossRefGoogle Scholar
  67. 67.
    Long RG, Scheur PJ, Sherlock S: Pre-eclampsia presenting with deep jaundice. J Clin Pathol 30: 212–216, 1979.CrossRefGoogle Scholar
  68. 68.
    Aarnoudse JG, Houthoff HJ, Weits J, Vellenga E, Huisjes HJ: A syndrome of liver damage and intravascular coagulation in the last trimester of normotensive pregnancy. A clinical and histopathological study. Br J Obstet Gynaecol 94: 145–155, 1986.Google Scholar
  69. 69.
    Hague WM, de Swiet M: A syndrome of liver damage and intravascular coagulation in the late trimester of normotensive pregnancy. A clinical and histopathological study. Br J Obstet Gynaecol 93: 1113–1114, 1986.PubMedGoogle Scholar
  70. 70.
    Riely CA, Lathew PS, Romero R, Duffy TP: Acute fatty liver of pregnancy: a reassessment based on observations in nine patients. Ann Intern Med 106: 703–706, 1987.PubMedCrossRefGoogle Scholar
  71. 71.
    Quigley MM: Acute obstetric yellow atrophy presenting as idiopathic hyperuricaemia. Southern Med J 67: 142–146, 1974.PubMedCrossRefGoogle Scholar
  72. 72.
    Editorial: Haemolytic uraemic syndrome. Lancet 2: 1078 1079, 1984.Google Scholar
  73. 73.
    Hayslett JP: Postpartum renal failure. N Engl J Med 312: 1556–1559, 1985.PubMedCrossRefGoogle Scholar
  74. 74.
    Sun NCJ, Johnson SJ, Sung DTW, Woods JE: Idiopathic postpartum renal failure: review and case report of a successful renal transplantation. Mayo Clin Proc 50: 395–401, 1975.PubMedGoogle Scholar
  75. 75.
    Segonds A, Louradour N, Sue JM, Orfila C: Postpartum hemolytic uremic syndrome: a study of three cases and review of the literature. Clin Nephrol 12: 229–242, 1979.PubMedGoogle Scholar
  76. 76.
    Drummond KN: Hemolytic uremic syndrome-then and now. N Engl J Med 312 (2): 116–118, 1985.PubMedCrossRefGoogle Scholar
  77. 77.
    Conger JD, Falk SA, Gugengenheim SJ: Glomerular dynamics and morphologic changes in the generalised Schwartzman reaction in postpartum rats. J Clin Invest 67: 1334–1346, 1981.PubMedCrossRefGoogle Scholar
  78. 78.
    Karmali MA, Petric M, Steele BT, Lim C: Sporadic cases of haemolytic-uraemic syndrome associated with faecal cytotoxin and cytotoxin-producing Escherichia coli in stools. Lancet 1: 619–629, 1983.PubMedCrossRefGoogle Scholar
  79. 79.
    Vintzileso AM, Turner GW, Campbell WA, Weinbaum PJ, Ward SM, Nochimson DJ: Polyhydramnios and obstructive renal failure: a case report and review of the literature. Am J Obstet Gynecol 152: 883–885, 1985.Google Scholar
  80. 80.
    Seeds JW, Cefalo RC, Herbert WNP, Bowes WA: Hydramnios and maternal renal failure: relief with fetal therapy. Obstet Gynecol 64: 268–295, 1984.Google Scholar
  81. 81.
    Meares EM: Clinical implications of ureteral reflux in pregnancy. Clin Obstet Gynecol 21: 863–873, 1978.CrossRefGoogle Scholar
  82. 82.
    Warren DJ: Acute renal failure: diagnosis of cause within hours. Br Med J 294:1569-••, 1987.Google Scholar
  83. 83.
    Werko L, Bucht H: Glomerular filtration rate and renal blood flow in patients with chronic diffuse glomerulonephritis during pregnancy. Acta Med Scand 153: 177–186, 1956.PubMedCrossRefGoogle Scholar
  84. 84.
    Kaplan AL, Smith JP, Tillman AJB: Healed acute and chronic nephritis in pregnancy. Am J Obstet Gynecol 83: 1519–1525, 1962.PubMedGoogle Scholar
  85. 85.
    Felding CF: Obstetric aspects in women with histories of renal disease. Acta Obstet Gynecol Scand 38: 2–43, 1969.Google Scholar
  86. 86.
    Strauch BS, Hayslet JP: Kidney disease and pregnancy. Br Med J 4: 578–582, 1974.PubMedCrossRefGoogle Scholar
  87. 87.
    Bear RA: Pregnancy in patients with renal disease: a study of 44 cases. Obstet Gynecol 48: 13–18, 1976.PubMedGoogle Scholar
  88. 88.
    Leppert P, Tisher CC, Shu-Chung SC, Harlan WR: Antecedent renal disease and the outcome of pregnancy. Ann Intern Med 90: 747–751, 1979.PubMedCrossRefGoogle Scholar
  89. 89.
    Klockars M, Saarikes S, Ilonen E, Kuhlback BC: Pregnancy in patients with renal disease. Acta Med Scand 207: 207–214, 1980.PubMedCrossRefGoogle Scholar
  90. 90.
    Katz AI, Davison JM, Hayslett JP, Singson E, Lindheimer MD: Pregnancy in women with kidney disease. Kidney Int 18: 192–206, 1980.PubMedCrossRefGoogle Scholar
  91. 91.
    Surian M, Imbasciati E, Cosci P, Banfi G, Barbiano Di Belgeojoso G, Brancaccio D, Minetti L, Ponticelli C: Glomerular disease and pregnancy: a study of 123 pregnancies in patients with primary and secondary glomerular disease. Nephrology 36: 101–195, 1984.Google Scholar
  92. 92.
    Abe S: Pregnancy in glomerulonephritic patients with decreased renal function. Hypertension in Preg. 15: 305–312, 1996.CrossRefGoogle Scholar
  93. 93.
    Katz AI, Lindheimer MD: Does pregnancy aggravate primary glomerular disease? Am J Kidney Dis 6: 261–265, 1985.PubMedGoogle Scholar
  94. 94.
    Jungers P, Houillier P, Henry-Awar M: Specific controversies concerning the natural history of renal disease in pregnancy. Am J Kidney Dis 17: 116–122, 1991.PubMedGoogle Scholar
  95. 95.
    Jungers P, Houillier P, Forget D, Labrunie M, Skkiri H, Giatras I, Descamps-Latscha B: Influence of pregnancy on the course of primary chronic glomerulonephritis. Lancet 346: 1122–1124, 1995.PubMedCrossRefGoogle Scholar
  96. 96.
    Lindheimer MD, Katz AI: Gestation in women with kidney disease: prognosis and management. Clin Obstet Gynaecol (Balliere) 8: 387–404, 1994.CrossRefGoogle Scholar
  97. 97.
    Packham DK, North RA, Fairley KF, Kincaid-Smith PS: IgA nephropathy and pregnancy. Clin Nephrol 30: 15–21, 1988.PubMedGoogle Scholar
  98. 98.
    Hou SH, Grossman SD, Madias NE: Pregnancy in women with renal disease and moderate renal insufficiency. Am J Med 78: 185–194, 1985.PubMedCrossRefGoogle Scholar
  99. 99.
    Cunningham FG, Cox SM, Harstaol TW, Mason RA, Pritichard JA: Chronic renal disease and pregnancy outcome. Am J Obstet Gynecol 163 (2): 453–459, 1990.PubMedCrossRefGoogle Scholar
  100. 100.
    Imbasciati E, Pardi G, Capetta P, Albroso G, Bozzetti P, Pagliari B, Ponticelli C: Pregnancy in women with chronic renal failure. Am J Nephrol 6: 193–198, 1986.PubMedCrossRefGoogle Scholar
  101. 101.
    Hou S: Frequency and outcome of pregnancy in women on dialysis. Am J Kidney Dis 23: 60–63, 1994.PubMedGoogle Scholar
  102. 102.
    Holley JL, Bernardini J, Quadri KHM, Greenbery A, Laifer SA: Pregnancy outcomes in a prospective method control study of pregnancy and renal disease. Clin Nephrol 45: 77–82, 1996.PubMedGoogle Scholar
  103. 103.
    Jungers P: Reflux nephropathy and pregnancy. Clin Obstet Gynaecol (Balliere) 8: 425–442, 1994.CrossRefGoogle Scholar
  104. 104.
    Lim VS: Reproductive endocrinology in uremia. Clin Obstet Gynaecol (Balliere) 8: 469–480, 1994.CrossRefGoogle Scholar
  105. 105.
    Jones DC, Hayslett JP: Outcome of pregnancy in woman with moderate or severe renal in sufficiency. New England, J Med 335: 226–232, 1996.Google Scholar
  106. 106.
    Goldmith JH, Menzies DN, De Boer CH, Caplan W: Delivery of healthy infants after five week’s dialysis treatment for fulminating toxaemia of pregnancy. Lancet 2: 738–740, 1971.CrossRefGoogle Scholar
  107. 107.
    Schewitz LJ, Friedman EA, Pollak VE: Bleeding after renal biopsy in pregnancy. Obstet Gynecol 26: 295–304, 1965.PubMedGoogle Scholar
  108. 108.
    Lindheimer MD, Spargo BH, Katz AI: Renal biopsy in pregnancy-induced hypertension. J Reprod Med 15: 189194, 1975.Google Scholar
  109. 109.
    Lindheimer MD, Davison JM: Renal biopsy during pregnancy: “To b... or not to bchrw(133) ?” Br J Obstet Gynaecol 94: 932–934, 1987.PubMedCrossRefGoogle Scholar
  110. 110.
    Packham D, Fairley KF: Renal biopsy: indications and complications in pregnancy. Br J Obstet Gynaecol 94: 935–939, 1987.PubMedCrossRefGoogle Scholar
  111. 111.
    Thacker SB, Berkelman R: Assessing the diagnostic accuracy and efficacy of selected antepartum fetal surveillance techniques. Obstet Gynecol Sury 41: 121–141, 1986.CrossRefGoogle Scholar
  112. 112.
    Hecker K, Campbell S: Characteristics of fetal venous blood flow under normal circumstances and during fetal disease. Ultrasound Obstet Gynaecol 7: 68–83, 1996.CrossRefGoogle Scholar
  113. 113.
    Dunlop W, Furness C, Hill LM: Maternal haemoglobin concentration, haemetocrit and renal handling of urate in pregnancies ending in the births of small-for-dates infants. Br J Obstet Gynaecol 156: 527–533, 1987.Google Scholar
  114. 114.
    Dunlop W, Hill LM, Landon MJ, Oxley A, Jones P: Clinical relevance of coagulation and renal changes in preeclampsia. Lancet 2: 346–349, 1978.PubMedCrossRefGoogle Scholar
  115. 115.
    Redman CWG, Beilin LJ, Bonnar J, Wilkinson RH: Plasma urate measurements in pre-eclampsia fetal death in hypertensive pregnancy. Lancet 1: 1370–1375, 1976.PubMedCrossRefGoogle Scholar
  116. 116.
    Chesley LC, Valenti C: The evaluation of tests to differentiate pre-eclampsia from hypertensive disease. Am J Obstet Gynecol 75: 1165–1173, 1958.PubMedGoogle Scholar
  117. 117.
    Hill LM, Furness C, Dunlop W: Diurnal variation of serum urate in pregnancy. Br Med J 2: 1250, 1977.Google Scholar
  118. 118.
    Beilin LJ, Redman CWG, Bonnar J: Hypertension in pregnancy. In: JGG Ledingham, ed. Advanced Medicine, vol 10. Pitman Medical, London, pp 3–20, 1974.Google Scholar
  119. 119.
    Naik RB, Clark AD, Warren DJ: Acute proliferative glomerulonephritis with crescents and renal failure in pregnancy successfully managed by intermittent haemodialysis. Br J Obstet Gynaecol 86: 819–822, 1979.PubMedCrossRefGoogle Scholar
  120. 120.
    Barron WM: Hypertension. In: WM Barron, MD Lindheimer, eds, Medical Disorders During Pregnancy, 2nd ed. Mosby-Yearbook, St. Louis, pp 1–36, 1995.Google Scholar
  121. 121.
    Barron WM, Lindheimer MD: Management of hypertension in pregnancy. In: JH Laragh, BM Brenner, eds, Hypertension: Pathophysiology, Diagnosis, and Management, 2nd ed. Raven Press, New York, pp 2427–2450, 1995.Google Scholar
  122. 122.
    National High Blood Pressure Education Program Working Group Report on High Blood Pressure in Pregnancy. Am J Obstet Gynecol 163: 1689–1712, 1990.CrossRefGoogle Scholar
  123. 123.
    Johenning AR, Barron WM: Indirect blood pressure measurement in pregnancy: Korotkoff phase 4 versus phase 5. Am J Obstet Gynecol 167: 577–580, 1992.PubMedCrossRefGoogle Scholar
  124. 124.
    Australasian Society of Hypertension and Pregnancy: Management of hypertension in pregnancy: executive summary. Med J Aust 158: 700–702, 1993.Google Scholar
  125. 125.
    Halligan A, O’Brien E, O’Malley K, et al.: Twenty-four hour ambulatory blood pressure measurement in a primigravid population. J Hypertens 11: 869–873, 1993.PubMedCrossRefGoogle Scholar
  126. 126.
    Cunningham FG, Lindheimer MD: Hypertension in pregnancy. N Eng! J Med 326: 927–932, 1992.CrossRefGoogle Scholar
  127. 127.
    Davison JM, Lindheimer MD: Hypertension and pregnancy. In: RW Schrier, CW Gottschalk, eds, Diseases of the Kidney. Little, Brown, Boston, pp 1505–1540, 1993.Google Scholar
  128. 128.
    Sibai BH: Treatment of hypertension in pregnant women. N Eng J Med 335: 257–264, 1996.CrossRefGoogle Scholar
  129. 129.
    Page EW, Christianson R: The impact of mean arterial pressure in the middle trimester upon the outcome of pregnancy. Am J Obstet Gynecol 125: 740–746, 1976.PubMedGoogle Scholar
  130. 130.
    Seligman SA: Diurnal blood-pressure variation in pregnancy. J Obstet Gynaecol Br Commonw 78: 417–422, 1971.PubMedCrossRefGoogle Scholar
  131. 131.
    Redman CWG: The use of antihypertensive drugs in hypertension in pregnancy. Clin Obstet Gynaecol 4: 685–699, 1977.PubMedGoogle Scholar
  132. 132.
    Woods JR Jr, Brinkman CR III: The treatment of gestational hypertension. J Reprod Med 15: 195–200, 1975.PubMedGoogle Scholar
  133. 133.
    Ferris TF: Toxemia of pregnancy: a model of human hypertension. Cardiovasc Med 2: 887–886, 1977.Google Scholar
  134. 134.
    Stavin MJ: Renal function and hypertension associated with pregnancy. J Am Obstet Assoc 80 258–263, 1980.Google Scholar
  135. 135.
    Chesley LC: Hypertension in pregnancy: definitions, familial factor and remote prognosis. Kidney Int 18: 234–240, 1980.PubMedCrossRefGoogle Scholar
  136. 136.
    Pritchard JA: Management of pre-eclampsia and eclampsia. Kidney Int 18: 259–266, 1980.PubMedCrossRefGoogle Scholar
  137. 137.
    Redman CWG, Beilin LJ, Bonnar J, Ounsted MK: Fetal outcome in trial of antihypertensive treatment in pregnancy. Lancet 2: 753–756, 1976.PubMedCrossRefGoogle Scholar
  138. 138.
    Redman CWG, Beilin LJ, Bonnar J: Treatment of hypertension in pregnancy with methyl dopa: blood pressure control side effects. Br J Obstet Gynaecol 84: 419–426, 1977.PubMedCrossRefGoogle Scholar
  139. 139.
    Kincaid-Smith P, Bullen M, Mills J: Prolonged use of methyl dopa in severe hypertension in pregnancy. Br Med J 1: 174276, 1966.Google Scholar
  140. 140.
    Leather HM, Humphreys DM, Baker P, Chadd MA: A controlled trial of hypotensive agents in hypertension in pregnancy. Lancet 2: 488–490, 1968.PubMedCrossRefGoogle Scholar
  141. 141.
    Moar VA, Jeffries MA, Mutch LMM, Ounsted MK, Redman CWG: Neonatal head circumference and the treatment of maternal hypertension. Br J Obstet Gynaecol 85: 933–937, 1978.PubMedCrossRefGoogle Scholar
  142. 142.
    Ounsted MK, Moar VA, Good PJ, Redman CWG: Hypertension during pregnancy with and without specific treatment: the children at age of 4 years. Br J Obstet Gynaecol 87: 19–24, 1980.PubMedCrossRefGoogle Scholar
  143. 143.
    Widerlov E, Karlman I, Starsater J: Hydralazine-induced neonatal thrombocytopenia. N Engl J Med 303: 1235, 1980.PubMedGoogle Scholar
  144. 144.
    Shcroeder JS, Harrison DC: Repeated cardioversion during pregnancy: treatment of refractory paroxysmal atrial tachycrdia during three successive pregnancies. Am J Cardiol 27: 445–445, 1971.CrossRefGoogle Scholar
  145. 145.
    Burrow GN: Hyperthyroidism during pregnancy. N Engl J Med 298: 150–153, 1978.PubMedCrossRefGoogle Scholar
  146. 146.
    Turner GM, Oakley CM, Dixon HG: Management of pregnancy complicated by hypertrophic obstructive cardiomyopathy. Br Med J 4: 281–284, 1968.PubMedCrossRefGoogle Scholar
  147. 147.
    Tunstall ME: The effect of propanolol on the onset of breathing at birth. Br J Anaesth 41: 792–794, 1969.PubMedGoogle Scholar
  148. 148.
    Gallery EDM, Saunders DM, Hymyor SM, Gyory AZ: Randomized comparison of methyl dopa and oxprenolol for treatment of hypertension of pregnancy. Br Med J 1: 1591 1594, 1979.Google Scholar
  149. 149.
    Gladstone GR, Gersony WM: Propranolol administration during pregnancy: effects on the fetus. J Paediatr 86: 962–946, 1975.CrossRefGoogle Scholar
  150. 150.
    Cottril CM, McAllister RG, Bettes L, Noonan JA: Propranolol administration during pregnancy, labour and delivery: evidence for transplacental drug transfer and impaired neonatal drug disposition. J Paediatr 91: 812–814, 1977.CrossRefGoogle Scholar
  151. 151.
    Habib A, McCarthy JS: Effects on the neonate of propranolol administered during pregnancy. J Paediatr 91: 808811, 1977.Google Scholar
  152. 152.
    Lieberman BA, Stittat GM, Cohen SL, Beard RW, Picker GD, Belsey E: The possible adverse effect of propranolol on the fetus in pregnancies complicated by severe hypertension. Br J Obstet Gynaecol 85: 678–683, 1978.PubMedCrossRefGoogle Scholar
  153. 153.
    Dumez Y, Tchobroutsky C, Hornych H, Amiel-Tison C: Neonatal effects of maternal administration of acebutolol. Br Med J 2: 1077–1079, 1981.CrossRefGoogle Scholar
  154. 154.
    Lamming GD, Broughton Pipkin F, Symonds ED: Comparison of the alpha and beta blocking drug. Labetolol and methyldopa in the treatment of moderate and severe pregnancy-induced hypertension. Clin Exp Hypertens 2: 865895, 1980.Google Scholar
  155. 155.
    Redman CWG: A controlled trial of the treatment of hypertension in pregnancy: Labetalol compared with Methyldopa. In: A Riley, EM Symonds, eds, The Investigation of Labetalol in the Management of Hypertension in Pregnancy. Excerpta Medica, Amsterdam, pp 101–110, 1982.Google Scholar
  156. 156.
    Childress CH, Katz VL: Nifedipine and its indications in obstetrics and gynecology. Obstet Gynecol 83: 616–624, 1994.PubMedCrossRefGoogle Scholar
  157. 157.
    Lindow SW, Davies N, Davey DA, et al.: The effect of sublingual nifedipine on uteroplacental blood flow in hypertensive pregnancy. Br J Obstet Gynaecol 95: 1276–1281, 1988.PubMedCrossRefGoogle Scholar
  158. 158.
    Collins R, Yusuf S, Peto R: Overview of randomized trials of diuretics in pregnancy. Br Med J 290: 17–23, 1985.CrossRefGoogle Scholar
  159. 159.
    Finnerty JA: Hypertension and pregnancy. In: J Genest, E Koiw, O Kuchel, eds, Hypertension. McGraw Hill, New York, pp 866–873, 1977.Google Scholar
  160. 160.
    Christianson R, Page EW: Diuretic drug and pregnancy. Obstet Gynecol 48: 647–652, 1976.PubMedGoogle Scholar
  161. 161.
    Gant NF, Worley RI: Hypertension in Pregnancy: Concepts and Management. Appleton-Century-Crofts, New York, 1980.Google Scholar
  162. 162.
    Wallenbug HCSA, Haemodynamics in hypertensive pregnancy. In: SC Rubin, ed, Handbook of Hypertension, Vol 10, Hypertension in Pregnancy. Elsevier, Amsterdam, pp 66–101, 1988.Google Scholar
  163. 163.
    Howie PW, Prentice CRM, Forbes CD: Failure of heparin therapy to affect the clinical course of severe pre-eclampsia. Br J Obstet Gynaecol 82: 711–717, 1975.PubMedCrossRefGoogle Scholar
  164. 164.
    Gallery EDM, Delprada W, Gyory AZ: Antihypertensive effect of plasma volume expansion in pregnancy-associated hypertension. Aust NZ J Med 2: 20–24, 1981.Google Scholar
  165. 165.
    Cotton DB, Gonik B, Spillman T: Intrapartum to postpartum changes in colloid osmotic pressure. Am J Obstet Gynecol 149: 174–178, 1984.PubMedGoogle Scholar
  166. 166.
    Zinaman M, Rubin J, Lindheimer MD: Serial plasma oncotic pressure levels and echoencephalography during and after delivery in severe pre-eclampsia. Lancet 1: 1245–1257, 1985.PubMedCrossRefGoogle Scholar
  167. 167.
    Hankins GP, Wendel GD, Cunningham FG, Leveno KG: Longitudinal evaluation of hemodynamic changes in eclampsia. Am J Obstet Gynecol 150: 506–509, 1984.PubMedGoogle Scholar
  168. 168.
    d’Apice AJF, Reti LL, Pepperell RJ, et al.: Treatment of severe pre-eclampsia by plasma exchange. Aust N Z J Obstet Gynaecol 20: 321–235, 1980.Google Scholar
  169. 169.
    Martin JNJ, Files JC, Blake PG, et al.: Plasma exchange for preeclampsia. I. Postpartum use for persistently severe pre-eclampsia with HELLP syndrome. Am J Obstet Gynecol 162: 126–137, 1990.PubMedCrossRefGoogle Scholar
  170. 170.
    Crandon AJ, Isherwood DM: Effect of aspirin on incidence of pre-eclampsia. Lancet 1: 356–358, 1979.Google Scholar
  171. 171.
    August P, Lindheimer MD: Pathophysiology of pre-eclampsia. In: JH Laragh, BM Brenner, eds, Hypertension: Pathophysiology, Diagnosis, and Management. 2nd ed. Raven Press, New York, pp 2407–2426, 1995.Google Scholar
  172. 172.
    Beaufils M, Uzan S, Donsimoni R, Colan JC: Prevention of pre-eclampsia by early antiplatelet therapy. Lancet 1: 840842, 1985.Google Scholar
  173. 173.
    Van Asche FA, Spitz B, Vermylen J, Deckmijn H: Preliminary observations on treatment of pregnancy-induced hypertension with a thromboxane synthetase inhibitor. Am J Obstet Gynecol 148: 26–218, 1984.Google Scholar
  174. 174.
    Wallenburg HCS, Dekker Ga, Makovitz JW, Rotmans P: Low-dose aspirin prevents pregnancy-induced hypertension and pre-eclampsia in angiotensin-sensitive primigravidae. Lancet 1: 1–4, 1986.PubMedCrossRefGoogle Scholar
  175. 175.
    Sibai BM, Caritis SN, Thom E, et al.: Low-dose aspirin to prevent preeclampsia in healthy, nulliparous, pregnant women. N Engl J Med 329: 1213–1218, 1993.PubMedCrossRefGoogle Scholar
  176. 176.
    Italian Study of Aspirin in Pregnancy: Low-dose aspirin in prevention and treatment of intrauterine growth retardation and pregnancy-induced hypertension. Lancet 341: 396–400, 1993.Google Scholar
  177. 177.
    CLASP (Collaborative Low-dose Aspirin Study in Pregnancy) Collaborative Group: A randomized trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women. Lancet 343: 619–6629, 1994.CrossRefGoogle Scholar
  178. 178.
    Collins R: Antiplatelet agents for IUGR and pre-eclampsia. In: MW Enkin, MJNC Keirse, MJ Renfrew, et al., eds, Pregnancy and Childbirth Module. Cochrane Database of Systematic Reviews: No 04000, Spring 1994. Published through “Cochrane Updates on Disk,” Update Software, Oxford, Disk Issue 3, 1994.Google Scholar
  179. 179.
    Schiff E, Peleg E, Goldenberg M, et al.: The use of aspirin to prevent pregnancy-induced hypertension and lower the ratio of thromboxane A2 to prostacyclin in relatively high risk pregnancies. N Engl J Med 321: 351–356, 1989.PubMedCrossRefGoogle Scholar
  180. 180.
    Morris JA, Arce JJ, Hamilton CJ, Davidson EC, Maidman JE, Clark JH, Bloom RS: The management of severe pre-eclampsia and eclampsia with intravenous diazoxide. Obstet Gynecol 49: 675–680, 1977.PubMedGoogle Scholar
  181. 181.
    Newman J, Weiss B, Rabello Y, Calbel L, Freeman RK: Diazoxide for the acute control of severe hypertension complicating pregnancy: a pilot study. Obstet Gynecol (Suppl): 50S - 55S, 1979.Google Scholar
  182. 182.
    Dudley DKL: Minibolus diazoide in the management of severe hypertension in pregnancy. Am J Obstet Gynecol 151: 196–200, 1985.PubMedGoogle Scholar
  183. 183.
    Walters BNJ, Redman CWG: Treatment of severe pregnancy associated hypertension with the calcium antagonist nifedipine. Br J Obstet Gynecol 91: 330–332, 1984.CrossRefGoogle Scholar
  184. 184.
    Shoemaker CT, Meyers M: Sodium introprusside for control of severe hypertensive disease of pregnancy: a case report and discussion of potential toxicity. Am J Obstet Gynecol 149: 171–174, 1984.PubMedGoogle Scholar
  185. 185.
    Montenegro R, Knuppel RA, Shah D: The effect of serotonergic blockade in postpartum pre-eclampsia patients. Am J Obstet Gynecol 153: 130–134, 1985.PubMedGoogle Scholar
  186. 186.
    Donaldson JO: Neurology in Pregnancy. WB Saunders, Philadelphia, 1978.Google Scholar
  187. 187.
    Belfort MA, Moise KJ Jr: Effect of magnesium sulfate on maternal brain blood flow in preeclampsia: a randomized, placebo-controlled study. Am J Obstet Gynecol 167: 661–666, 1992.PubMedCrossRefGoogle Scholar
  188. 188.
    Chua S, Redman CWG: Are prophylactic anticonvulsants required in severe preeclampsia? Lancet 337: 250–251, 1991.PubMedCrossRefGoogle Scholar
  189. 189.
    Eclampsia Trial Collaborative Group: Which anticonvulsant for women with eclampsia? Evidence from the Collaborative Eclampsia Trial. Lancet 345: 1455–1463, 1995.Google Scholar
  190. 190.
    Lucas MJ, Leveno KJ, Cunningham FG: A comparison of magnesium sulphate with phenytoin for the prevention of eclampsia. N Engl J Med 333: 201–205, 1995.PubMedCrossRefGoogle Scholar
  191. 191.
    Robert JM: Magnesium for pre-eclampsia and eclampsia. N Engl J Med 333: 250–251, 1995.CrossRefGoogle Scholar
  192. 192.
    Borgers LF, Gucer G: Effect of magnesium on edi foci. Epilepsis 29: 81–91, 1978.Google Scholar
  193. 193.
    Chien PFW, Khan KS, Arnott N: Magnesium sulphate in the treatment of eclampsia and pre-eclampsia: an overview of the ecidence from randeunced treals. Bit J Obstet Gynaecal 103: 1085–1091, 1996.CrossRefGoogle Scholar
  194. 194.
    Cree JE, Meyer J, Hailey DM: Diazepam in labor. Its metabolism and effect on the clinical condition and thermogenesis of the newborn. Br Med J 4: 251–255, 1973.PubMedCrossRefGoogle Scholar
  195. 195.
    Crawford JS: Epidural analgesia in pregnancy hypertension. Clin Obstet Gynecol 4: 735–749, 1977.Google Scholar
  196. 196.
    Joyce TH III, Debnath KS, Baker EA: Pre-eclampsia relationship of CVP and epidural analgesia. Anesthesiology 51: S297, 1979.CrossRefGoogle Scholar
  197. 197.
    Tatum HJ, Mule JG: Puerperal vasomotor collapse in patients with toxemia of pregnancy: a new concept of the etiology and a rational plan of treatment. Am J Obstet Gynecol 71: 492–498, 1956.PubMedGoogle Scholar
  198. 198.
    Shepherd J, Shepherd C: Post-streptococcal glomerulonephritis: a rare complication of pregnancy. J Fam Pract 34: 625–632, 1992.PubMedGoogle Scholar
  199. 199.
    Kincaid-Smith P, Fairley KF, Bullen M: Kidney disease and pregnancy. Med J Aust 2: 1155–1159, 1967.Google Scholar
  200. 200.
    Kincaid-Smith P, Whittworth JA, Fairley KF: Mesangial IgA nephropathy in pregnancy. Clin Exp Hyper B2: 821–838, 1980.CrossRefGoogle Scholar
  201. 201.
    Fairley KF, Whittworth JA, Kincaid-Smith P: Glomerulonephritis and pregnancy. In: P Kincaid-Smith, TH Mathew, EL Becker, eds, Glomerulonephritis (Part II), pp 997–1011, 1973. John Wiley & Sons, New York.Google Scholar
  202. 202.
    Cameron JS, Hicks J: Pregnancy in patients with pre-existing glomerular disease. Contr Nephrol 37: 1459–155, 1984.Google Scholar
  203. 203.
    Kincaid-Smith P, Fairley KF: Renal disease in pregnancy. Three controversial areas: mesangial IgA nephropathy, focal glomerular sclerosis (focal and segmental hyalinosis and sclerosis) and reflux nephropathy. Am J Kidney Dis 9: 328–333, 1987.PubMedGoogle Scholar
  204. 204.
    Grunfeld J-P, Noel LH, Hafez S, Droz D: Renal prognosis in women with hereditary nephritis. Clin Nephro 23: 267–270, 1985.Google Scholar
  205. 205.
    Rogers PW, Kurtzman NA, Bunn SM: Familial benign essential hematuria. Arch Intern Med 131: 257–259, 1973.PubMedCrossRefGoogle Scholar
  206. 206.
    Knebelmann B, Antiganac C, Gubler MC, Grunfeld JP: A molecular approach to inherited kidney disorders. Kidney Int 44: 1205–1216, 1993.PubMedCrossRefGoogle Scholar
  207. 207.
    Mro-Josef S, Navot D Rabinowitz R, Sehenker JG: Collagen disease in pregnancy. Obstet Gynecol Sury 39: 67–83, 1984.CrossRefGoogle Scholar
  208. 208.
    Lockshin MD, Druin ML: Rheumatic diseases. In: WM Barron, MD Lindheimer, eds, Medical Disorders During Pregnancy, 2nd ed. Mosby-Year Book, St. Louis, pp 301–337, 1995.Google Scholar
  209. 209.
    Jungers P, Dougados M, Pellissies C: Lupus nephropathy and pregnancy. Arch Intern Med 142: 771, 1982.PubMedCrossRefGoogle Scholar
  210. 210.
    Hayslett JP: The effect of SLE on pregnancy and pregnancy outcome. Am J Reprod Immunol 28: 199–204, 1992.PubMedCrossRefGoogle Scholar
  211. 211.
    Imbasciati E, Ponticelli C: Pregnancy and renal disease: predictors for fetal and maternal outcome. Am J Nephrol 11: 353–362, 1991.PubMedCrossRefGoogle Scholar
  212. 212.
    Nicklin JL: Systemic lupus erythematosus and pregnancy at the Royal Women’s Hospital, Brisbane 1979–1989. Aust NZ J Obstet Gynaecol 31: 128–133, 1991.CrossRefGoogle Scholar
  213. 213.
    Leikin JB, Arof HM, Pearlman LM: Acute lupus pneumonitis in the postpartum period. A case history and review of the literature. Obstet Gynecol 68: 293–315, 1986.Google Scholar
  214. 214.
    Kochenour NK, Branch WD, Rote NS, Scott JR: A new postpartum syndrome associated with antiphaspholipid antibodies. Obstet Gynecol 69: 460–468, 1987.PubMedGoogle Scholar
  215. 215.
    Lubbe WF, Butler WS, Palmer SJ, Liggins GC: Lupus anticoagulant in pregnancy. Br J Obstet Gynaecol 91 (4): 357–363, 1984.PubMedCrossRefGoogle Scholar
  216. 216.
    Arnout J, Spitz B, van Assche A: The antiphospholipid syndrome and pregnancy. Hypertens Pregnancy 14: 147–178, 1995.CrossRefGoogle Scholar
  217. 217.
    Singsen BH, Akhter JE, Weinstein MM, Sharp GC: Congenital complete heart block and SSA antibodies. Am J Obstet Gynecol 152: 655–659, 1985.PubMedGoogle Scholar
  218. 218.
    Skinner RP: Connective-tissue disease, antibodies to ribonucleoprotein and congenital heart block. N Engl J Med 309: 209–212, 1983.PubMedCrossRefGoogle Scholar
  219. 219.
    Taylor PV, Scott JS, Gerlis LM, Esscher E, Scott O: Maternal antibodies against fetal cardiac antigens in congenital complete heart block. N Engl J Med 315: 667–672, 1986.PubMedCrossRefGoogle Scholar
  220. 220.
    Kasinath BS, Katz AI: Delayed maternal lupus after delivery of offspring with congenital heart block. Arch Intern Med 142: 1217–1298, 1983.Google Scholar
  221. 221.
    Barclay CS, French MAH, Ross LD, Sokol RJ: Successful pregnancy following steroid therapy and plasma exchange in a woman with anti-Ro (SS-A) antibodies. Case report. Br J Obstet Gynaecol 94: 369–371, 1987.PubMedCrossRefGoogle Scholar
  222. 222.
    Smith CA: Progressive systemic sclerosis and post-partum renal failure complicated by peripheral gangrene. J Rheum 9: 455–460, 1982.PubMedGoogle Scholar
  223. 223.
    Magmon R, Fejgin M: Scleroderma in pregancy. Obstet Gynecol Sury 44: 530–534, 1989.CrossRefGoogle Scholar
  224. 224.
    Moore M, Saffon JE, Barof HSB: Systemic sclerosis and pregnancy complicated by obstructive uropathy. Am J Obstet Gynecol 153: 893–895, 1985.PubMedGoogle Scholar
  225. 225.
    Nagey DA, Fortier KJ, Linden J: Pregnancy complicated by periarteritis nodosa: induced abortion as an alternative. Am J Obstet Gynecol 147: 103–195, 1983.PubMedGoogle Scholar
  226. 226.
    Cousins L: Pregnancy complications among diabetic women: review 1965–1985. Obstet Gynecol Sury 42: 140–149, 1987.Google Scholar
  227. 227.
    Hayslett JP, Reece EA: Managing diabetic patients with nephropathy and other vascular complications. Clin Obstet Gynaecol (Balliere) 8: 405–424, 1994.CrossRefGoogle Scholar
  228. 228.
    Kimmerle R, Zass RD, Cupisti S: Pregnancies in women with diabetic nephropathy and long-term outcome for mother and child. Diabetologia 38: 227–235, 1995.PubMedCrossRefGoogle Scholar
  229. 229.
    Gordon M, Landon MB, Samuels P, Hissrich S, Gabbe S: Perinatal outcome and longterm follow-up associated with modern management of diabetic nephropathy. Obstet Gynecol 87: 401–409, 1996.PubMedCrossRefGoogle Scholar
  230. 230.
    Parving H-H, Andersen AR, Smidt UM, Hommonel E, Mathiesen ER, Svendsen PA: Effect of antihypertensive treatment on kidney function in diabetic nephropathy. Br Med J 294: 1443–1447, 1987.CrossRefGoogle Scholar
  231. 231.
    Becker GJ, Ihle BO, Fairley KF, Bastos M, Kincaid-Smith: Effect of pregnancy on moderate renal failure in reflux nephropathy. Br Med J 294: 796, 1986.CrossRefGoogle Scholar
  232. 232.
    Kincaid-Smith P, Fairley KF: Renal disease in pregnancy: three controversial areas: mesangial IgA nephropathy, focal glomerular sclerosis (focal and segmental hyalinosis and sclerosis) and reflux nephropathy. Am J Kidney Dis 9: 328–333, 1987.PubMedGoogle Scholar
  233. 233.
    Jungers P: Reflux nephropathy and pregnancy. Clin Obstet Gynaecol (Bailliere) 8: 245–242, 1994.Google Scholar
  234. 234.
    Maikranz P, Coe FL, Parks J, Lindheimer MD: Nephrolithiasis and gestation. Clin Obstet Gynaecol (Bailliere) 8: 375386, 1994.Google Scholar
  235. 235.
    Stothers L, Lee LM: Renal colic in pregnancy. J Urol 148: 1383–1381, 1992.PubMedGoogle Scholar
  236. 236.
    Klein EA: Urologic problems of pregnancy. Obstet Gynecol Sury 39: 605–615, 1983.CrossRefGoogle Scholar
  237. 237.
    Rodriguez PN, Klein AS: Management of urolithiasis during pregnancy. Surg Gynecol Obstet 166: 103–106, 1988.PubMedGoogle Scholar
  238. 238.
    Ready BL, Johnson ES: Epidural block for treatment of renal colic during pregnancy. Can Anaesth Soc J 28: 77–79, 1981.PubMedCrossRefGoogle Scholar
  239. 239.
    Miller DR, Kakkis J: Prognosis, management and outcome of obstructive renal disease in pregnancy. J Reprod Med 27: 199201, 1982.Google Scholar
  240. 240.
    Loughlin KR, Bailey RB: Internal ureteral stents for conservative management of ureteral calculi during pregnancy. N Engl J Med 315: 1647–1649, 1986.PubMedCrossRefGoogle Scholar
  241. 241.
    Van Sonnenberg E, Casola G, Talner LB, Wittich GR, Varney RR, D’Agostino HB: Symptomatic renal obstruction or urosepsis during pregnancy: treatment by sonographically guided percutaneous nephrostomy. Am J Roentgenol 158:9194, 1992.Google Scholar
  242. 242.
    Gregory MC, Mansell MA: Pregnancy and cystinuria. Lancet 2: 1158–1160, 1983.PubMedCrossRefGoogle Scholar
  243. 243.
    Bear JC, McManamon P, Morgan P: Age at clincial onset and at ultrasonographic detection of adult polycystic kidney disease: data for genetic counseling. Am J Med Genet 18: 45–59, 1984.PubMedCrossRefGoogle Scholar
  244. 244.
    Chapman AB, Johnson AM, Gabow PA: Pregnancy outcome and its relationship to progression of renal failure in autosomal dominant polycystic kidney disease. J Am Soc Nephrol 5: 1178–1185, 1994.PubMedGoogle Scholar
  245. 245.
    Gabow PA: Autosomal dominant polycystic kidney disease. N Engl J Med 329: 332–342, 1993.PubMedCrossRefGoogle Scholar
  246. 246.
    Schmidt WM, Waldhert R, Dolata MM, Davies KE, Weatherall DJ: Prenatal diagnosis of autosomal dominant polycystic kidney disease with a DNA probe. Lancet 2: 6–7, 1986.PubMedGoogle Scholar
  247. 247.
    Barrett RJ, Peters WA: Pregnancy following urinary diversion. Obstet Gynecol 62: 582–56, 1983.PubMedGoogle Scholar
  248. 248.
    Cunningham R, Popowniak KL, Streem SB, Steinhilber D, Brun WE: Pregnancy after donor nephrectomy. Transplantation 40: 651–655, 1985.PubMedCrossRefGoogle Scholar
  249. 249.
    Li FP, Gimbrere K, Gelber RD: Outcome of pregnancy in survivors of Wilm’s tumor. JAMA 257: 216–219, 1987.PubMedCrossRefGoogle Scholar
  250. 250.
    Murty GE, Davison JM, Cameron JS: Wegener’s granulomatosis complicating pregnancy: first report of a case with a tracheostomy. J Obstet Gynecol 10: 399–403, 1991.Google Scholar
  251. 251.
    Uribe LG, Vash DK, Krane NK: Steroid responsive nephotic syndrome with renal insufficiency in first trimester of pregnancy. Am J Obstet Gynecol 164: 568–569, 1991.PubMedCrossRefGoogle Scholar
  252. 252.
    Rosenbaum AI, Churchill JA, Shakhashiri ZA: Neuropsychologic outcome of children whose mothers had proteinuria during pregnancy. Obstet Gynecol 33: 118–123, 1969.PubMedCrossRefGoogle Scholar
  253. 253.
    Baylis C: The determinant of renal hemodynamics in pregnancy. Am J Kidney Dis 9: 260–264, 1987.PubMedGoogle Scholar
  254. 254.
    Baylis C: Renal disease in gravid animal models. Am J Kidney Dis 9: 350–353, 1987.PubMedGoogle Scholar
  255. 255.
    Confortini P, Galanti G, Ancona G, Giongo A, Lorenzini E: Full term pregnancy and successful delivery in a patient on chronic haemodialysis. In: JS Cameron, ed, Proceedings of the European Dialysis and Transplant Association. Pitman Medical, London, pp 74–78, 1971.Google Scholar
  256. 256.
    Hou S: Reproductive endocrinology in women on dialysis. Semin Dial 6: 57–58, 1993.Google Scholar
  257. 257.
    Hou SH: Pregnancy in women treated with peritoneal dialysis: viewpoint. Peritoneal Dial Intl 16: 442–443, 1996.Google Scholar
  258. 258.
    Ackrill P, Goodwin FJ, Marsh FP, Stratton D, Wagman H: Successful pregnancy in patient on regular dialysis. Br Med J 2: 172–174, 1975.PubMedCrossRefGoogle Scholar
  259. 259.
    Rigenbach M, Renger B, Beavais P, Imbs FJ, Eschbach J, Frey G: Grossesse et accouchment d’un enfant vivant dans une patiente traitte par haemodialyse iterative. J Urol Nephrol (Paris) 84: 360–366, 1979.Google Scholar
  260. 260.
    Hou SH: Pregnancy in women on hemodialysis and peritoneal dialysis. Clin Obstet Gynaecal (Bailliere) 8: 481–500, 1994.CrossRefGoogle Scholar
  261. 261.
    McGregor E, Stewart G, Junor BJR, Rodger RSC: Successful use of recombination human erythropoietin in pregnancy. Nephrol Dial Transplant 6: 292–293, 1991.PubMedCrossRefGoogle Scholar
  262. 262.
    Kioko EM, Shaw KM, Clark AD, Warren DJ: Successful pregnancy in a diabetic patient treated with continuous ambulatory peritoneal dialysis. Diabetes Care 6: 298–300, 1983.PubMedCrossRefGoogle Scholar
  263. 263.
    Redrow M, Cherem L, Elliott J, Mangalat J, Mishler RE, Bennett WM, Lutz M, Sigala J, Byrnes J, Phillippe M, Hou S, Schon D: Dialysis in the management of pregnant patients with renal insufficency. Medicine (Baltimore) 67: 199–209, 1988.Google Scholar
  264. 264.
    Goodship THJ, Heaton A, Rodger SC, Ward MK, Wilkinson R, Kerr DNS: Factors affecting development of peritonitis in continuous ambulatory peritoneal dialysis. Br Med J 298: 1485–1486, 1984.CrossRefGoogle Scholar
  265. 265.
    Gotloib L, Shustak A, Varka I, Haas R, Mines M, Weiss Z: What is the acute incidence of peritonitis in maintenance peritoneal dialysis? A prospective study. Artif Organs 9: 160163, 1985.Google Scholar
  266. 266.
    Rubin J, Rogers WA, Taylor HM, Everett ED, Prowant BF, Fruto LV, Nolph KD: Peritonitis during continuous ambulatory peritoneal dialysis. Ann Intern Med 92: 7–13, 1980.PubMedCrossRefGoogle Scholar
  267. 267.
    Blumenkrantz MJ, Gallagher N, Bashore RA, Tenckhoff MD: Retrograde menstruation in women undergoing chronic peritonal dialysis. Obstet Gynecol 57: 667–670, 1981.PubMedGoogle Scholar
  268. 268.
    Merkatz IR, Schwartz GH, David DS, Stenzel KH, Riggio RR, Whitsell JC: Resumption of female reproductive function following renal transplantation. JAMA 216: 1749–1754, 1971.PubMedCrossRefGoogle Scholar
  269. 269.
    Editorial: Pregnancy after renal transplantation. Br Med J 1:733–734, 1976Google Scholar
  270. 270.
    Davison JM: Pregnancy in renal allograft recipients: prognosis and management. Clin Obstet Gynaecol (Balliere) 8: 50 1525, 1994.Google Scholar
  271. 271.
    Penn I, Makowski EL, Harris PL: Parenthood following renal transplantation. Kidney Int 187: 221–233, 1980.CrossRefGoogle Scholar
  272. 272.
    Ehrich JHH, Loirat C, Davison JM, Rizzoni G, Witkop B, Selwood NH, Mallick NP: Repeated successful pregnancies after kidney transplantation in 102 women. Nephrol Dial Transplant 11: 1314–1317, 1996.PubMedGoogle Scholar
  273. 273.
    Lau RJ, Scott JR: Pregnancy following renal transplantation. Clin Obstet Gynecol 27: 902–913, 1984.CrossRefGoogle Scholar
  274. 274.
    O’Donnell D, Sevitz H, Seggie JL, Meyers AM, Botha JR, Myburgh JA: Pregnancy after renal transplantation. Aust NZ J Med 15: 320–332, 1985.CrossRefGoogle Scholar
  275. 275.
    Davison JM: Towards longterm graft surival in renal transplantation: pregnancy. Nephrol Dial Transplant 10 (Suppl 1): 85–89, 1995.PubMedCrossRefGoogle Scholar
  276. 276.
    Penn I: Pregnancy following renal transplantation. In: VE Andreucci, ed, The Kidney in Pregnancy. Martinus Nijhoff, Boston, pp 195–204, 1985.Google Scholar
  277. 277.
    Ibels LS, Alfrey AC, Huffer WE: Aseptic necrosis of bone. The 13th report of the human renal transplant registry. Transplant Proc 9: 9–26, 1977.Google Scholar
  278. 278.
    U.K. Transplant Service Annual Report,pp 26–36, 1981.Google Scholar
  279. 279.
    Rizzoni G, Ehrich JHH, Broyer M, Brunner FP, Brynger H, Fassbinder W, Geerlings W, Selwood NH, Tufveson G, Wing AJ: Successful pregnancies in women on renal replacement therapy: report from the EDTA Registry. Nephrol Dial Transplant 7: 1–9, 1992.Google Scholar
  280. 280.
    Sturgiss SN, Davison JM: Effect of pregnancy on long term function of renal allografts. Am J Kidney Dis 19: 167–172, 1992.PubMedGoogle Scholar
  281. 281.
    Salmela KT, Kyllonen LEJ, Holmberg C, Glonhagen-Riska C: Impaired renal function after pregnancy in renal transplant recipients. Transplantation 56: 1372–1375, 1993.PubMedCrossRefGoogle Scholar
  282. 282.
    Sturgiss SN, Davison JM: Effect of pregnancy on the longterm function of renal allografts: an update. Am J Kidney Dis 26: 54–56, 1995.PubMedCrossRefGoogle Scholar
  283. 283.
    First MR, Combs A, Weiskittel P, et al.: Lack of effect of pregnancy on renal allograft survival or function. Transplantation 59: 472–476, 1995.PubMedGoogle Scholar
  284. 284.
    Scott JR, Cruikshank D, Corry RJ: Ectopic pregnancy in kidney transplant patients. Obstet Gynecol 51: 565–585, 1978.Google Scholar
  285. 285.
    Davison JM: The effect of pregnancy on kidney function in renal allograft recipients. Kidney Int 27: 74–79, 1985.PubMedCrossRefGoogle Scholar
  286. 286.
    Brynger H, Fassbinder W, Geerlings W, Selwood NH, Tufveson G, Wing AJ: Successful pregnancies in women on renal replacement therapy: report from the EDTA Registry. Nephrol Dial Transplant 7: 1–9, 1992.Google Scholar
  287. 287.
    Riffe G, Traeger J: Pregnancy after renal tansplantation: an international review. Transplant Proc (Suppl) 1: 723–728, 1975.Google Scholar
  288. 288.
    Sturgiss SN, Davison JM: Perinatal outcome in renal allograft recipients: prognostic significance of hypertension and renal function before and during pregnancy. Obstet Gynecol 78: 573–577, 1991.PubMedGoogle Scholar
  289. 289.
    Williams PF, Jelen J: Eclampsia in a patient who had had a renal transplant. Br Med J 2: 972, 1979.PubMedCrossRefGoogle Scholar
  290. 290.
    Remuzzi G, Ruggenenti P, Mauer SM: Pancreas and pancreas/kidney transplants: experimental medicine or real improvement? Lancet 343: 27, 1994.PubMedCrossRefGoogle Scholar
  291. 291.
    Holt DW, Mueller EA, Kovarik JM, Vaubree JB, Kutz K: The phamacokiretics of Sandimman Neoral: a new oral formulation of cyclospanine. Transpl Proc 26: 2935–2939, 1994.Google Scholar
  292. 292.
    Gaughan WJ, Moritz MJ, Radomski IS, Burke JF, Armenti VT: National Transplantation Pregnancy Registry: repat on outcome in cyclospanine-treated female kidney transplant recipients with an interval for transplant to pregnancy of greater than 5 years. Am J Kid Dis 28: 266–269, 1996.PubMedCrossRefGoogle Scholar
  293. 293.
    Caine RY: Cyclosporin in cadaveric renal transplantation: 5 year follow-up of a multicentre trial. Lancet 2: 506–507, 1987.Google Scholar
  294. 294.
    Blumenkrantz MJ, Gallagher N, Bashore RA, Tenckhoff MD: Retrograde menstruation in women undergoing chronic peritoneal dialysis. Obstet Gynecol 57: 667–670, 1981.PubMedGoogle Scholar
  295. 295.
    Flechner SM, Katz AR, Rogers AJ, Van Buren C, Kahan BD: The presence of cyclosporine in body tissues and fluids during pregnancy. Am J Kidney Dis 5: 6–63, 1985.Google Scholar
  296. 296.
    Bar J, Fisch B, Wittenbery C, Gelerenter I, Boner G, Hod M: Pridmisont dosage and pregnancy outcome in renal allograft recipients. Nephrol Dial Transpl 12:760–763 Google Scholar
  297. 297.
    Ahlswede KM, Armenti VT, Moritz M: Premature births in female transplant recipients: degree and effect of immunosuppressive regimen. Surg Forum 43: 524–525, 1992.Google Scholar
  298. 298.
    Armenti VT, Ahlsweke KM, Ahlswede BA, Mortiz MJ, Jarrell BE, Burke JF: The National Transplant Registry: an analysis of 325 pregnancies in female kidney recipients. J Am Soc Nephrol 3: 851P, 1992.Google Scholar
  299. 299.
    Armenti VT, Ahlswede BA, Moritz MJ, Jarrell BE: National Transplantation Registry: analysis of pregnancy outcomes of female kidney recipients with relation to time interval from transplantation to conception. Transplant Proc 25: 1036–1037, 1993.PubMedGoogle Scholar
  300. 300.
    Davison JM, Redman CWG: Pregnancy post-transplant: the establishment of a UK Registry. Brit J Obstet Gynaecol In press.Google Scholar
  301. 301.
    Myerowitz RL, Medeiros AA, O’Brien TF: Bacterial infection in renal homotransplant recipients: a study of fifty-three bacteremic episodes. Am J Med 53: 308–314, 1972.PubMedCrossRefGoogle Scholar
  302. 302.
    Nolan GH, Sweet RL, Laros RK, Roure CA: Renal cadaver transplantation followed by successful pregnancies. Obstet Gynecol 43 (5): 732–739, 1974.PubMedGoogle Scholar
  303. 303.
    Faber M, Kennison RD, Jackson Ht, Sbarra AJ, Widnere JB: Successful pregnancy after renal transplantation. Obstet Gynecol 48: 2–4, 1976.Google Scholar
  304. 304.
    Coyne SS, Walsh JW, Tisnado J, Brewer WH, Sharpe AR, Amendola MA, Mendez-Picon G, Lee HM: Surgically correctable renal transplant complications: an integrated clinical and radiologic approach. Am J Radiol 136: 1113 1119, 1981.Google Scholar
  305. 305.
    Cunningham RJ, Buszta C, Braun WE, Skinmuller D, Novick AC, Popowriak K: Pregnancy in renal allograft recipients and long term follow up of their offspring. Transplant Proc 15: 1067–1070, 1983.Google Scholar
  306. 306.
    Haugen G, Fauchald P, Sodal G, Halvorsen S, Oldereid N, Moe N: Pregnancy outcome in renal allograft recipients: influence of cyclosporin A. Eur J Obstet Gynaecol Reprod Biol 29: 25–29, 1991.CrossRefGoogle Scholar
  307. 307.
    Pickrell MD, Sawers R, Michael J: Pregnancy after renal transplantation: severe intrauterine growth retardation during treatment with cyclosporin A. Br Med J 296: 825, 1988.CrossRefGoogle Scholar
  308. 308.
    Davison JM, Lindheimer MD: Pregnancy and renal tansplantation: look before you leap. Int J Artif Organs 12: 144–146, 1989.PubMedGoogle Scholar
  309. 309.
    Price HV, Salaman JR, Laurence KM, Langmaid H. Immunosuppressive drugs and the fetus. Transplantation 21: 294298, 1976.Google Scholar
  310. 310.
    Reimbers TJ, Sluss PM: 6-mercaptopurine treatment of pregnant mice: effects on second and third generations. Science 201: 65–67, 1978.CrossRefGoogle Scholar
  311. 311.
    Korsch BM, Klein JD, Negrete VF, Henderson DJ, Fine RN: Physical and psychological follow-up on offspring of renal allograft recipents. Pediatrics 65: 275–283, 1980.PubMedGoogle Scholar
  312. 312.
    London N, Farmen SM, Will EJ, Davison AM, Lodge JPA: Risk of neoplasira in renal transplant recipients. Lancet 346: 403–406, 1995.PubMedCrossRefGoogle Scholar
  313. 313.
    Opelz G: Are post transplant hymphomas ineritable? Nephrol Dial Transplant 11: 1952–1955, 1996.PubMedCrossRefGoogle Scholar
  314. 314.
    Poreco R, Penn I, Droegemneller W, Greer B, Makowski EL: Gynecologic malignancies in immunosuppressed organ homograft recipients. Obstet Gynecol 45: 359–364, 1975.Google Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • John M. Davison
    • 1
  • Adrian I. Katz
    • 2
  • Marshall D. Lindheimer
    • 2
  1. 1.Department of Obstetrics and GynaecologyUniversity of Newcastle, Royal Victoria InfirmaryNewcastle upon TyneEngland
  2. 2.Departments of Obstetrics and of Gynecology and Medicine, Sections of Nephrology and of Maternal Fetal MedicineThe University of ChicagoChicagoUSA

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