Goodpasture’s Syndrome

  • David I. Charney
  • Wayne A. Border


In 1919, Ernest Goodpasture described the case of a young man with a fatal illness characterized by hemoptysis, alveolar hemorrhage and necrosis, and proliferative glomerulonephritis (1). Stanton and Tange, in 1958, were the first to use the eponym Goodpasture’s syndrome to describe cases of pulmonary hemorrhage and necrotizing glomerulonephritis (2), although a large number of similar cases have been reported in the literature since the original description by Goodpasture. The original diagnosis of this syndrome was based on the clinical presence of pulmonary and renal involvement, and the underlying pathology described in literature reports varied. As we have come to understand, such pulmonary-renal syndromes have more than one etiology (Table 1).


Glomerular Basement Membrane Pulmonary Hemorrhage Alport Syndrome Tubular Basement Membrane Antiglomerular Basement Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • David I. Charney
    • 1
  • Wayne A. Border
    • 2
  1. 1.Division of Nephrology Department of MedicineUniversity of Utah School of MedicineSalt Lake CityUSA
  2. 2.Division of NephrologyUniversity of Utah School of MedicineSalt Lake CityUSA

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