Therapy of Lactic Acidosis

  • Christine P. Bastl
  • Michael Heifets
  • Louis J. RileyJr.


Lactic acidosis is a critical and usually fatal complication of many severe disease processes. There is a logarithmic increase in mortality as lactic acid levels rise above 5 mmol/L. A rise in serum lactate signifies that homeostatic mechanisms are desperately compromised. Treatment of the acidemia without correcting the underlying pathology is doomed to failure. Lactic acid production will outpace attempts at correction as the disease process worsens. Thus, the most important goals of therapy are recognition, diagnosis, and correction of the disturbance leading to excessive lactic acid production. Therapeutic maneuvers to correct the acidic milieu may allow stabilization of the patient for a long enough period to allow the definitive therapy to become effective.


Lactic Acid Lactate Level Lactic Acidosis Oxygen Delivery Lactic Acid Production 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Christine P. Bastl
    • 1
  • Michael Heifets
    • 2
  • Louis J. RileyJr.
    • 2
  1. 1.Temple University Health Sciences CenterPhiladelphiaUSA
  2. 2.Division of NephrologyTemple University Health Sciences CenterPhiladelphiaUSA

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