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Inhibition of Cell Division and Stimulation of Progesterone Receptor Synthesis in Rat Oestrogen Target Tissues by Non-Steroidal Antioestrogens

  • Chapter
Steroid Hormone Receptor Systems

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 117))

Abstract

Tamoxifen and monohydroxytamoxifen (Fig. 1) are non-steroidal compounds that antagonise the effects of oestradiol in the rat (1–4). However, although they are antioestrogenic they also possess atypical oestrogenic activity and are probably best described as partial agonists.

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Author information

Authors and Affiliations

  1. Department of Pharmacology, Medical and Dental Building, University of Leeds, Leeds, LS2 9JT, UK

    V. C. Jordan, C. J. Dix & G. Prestwich

Authors
  1. V. C. Jordan
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  2. C. J. Dix
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  3. G. Prestwich
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Editor information

Editors and Affiliations

  1. Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts, USA

    Wendell W. Leavitt

  2. Baylor College of Medicine, Houston, Texas, USA

    James H. Clark

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© 1979 Springer Science+Business Media New York

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Jordan, V.C., Dix, C.J., Prestwich, G. (1979). Inhibition of Cell Division and Stimulation of Progesterone Receptor Synthesis in Rat Oestrogen Target Tissues by Non-Steroidal Antioestrogens. In: Leavitt, W.W., Clark, J.H. (eds) Steroid Hormone Receptor Systems. Advances in Experimental Medicine and Biology, vol 117. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6589-2_7

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  • DOI: https://doi.org/10.1007/978-1-4757-6589-2_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6591-5

  • Online ISBN: 978-1-4757-6589-2

  • eBook Packages: Springer Book Archive

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