Estrogen Control of Progesterone Receptor Induction in Human Breast Cancer: Role of Nuclear Estrogen Receptor

  • Kathryn B. Horwitz
  • William L. McGuire
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 117)

Abstract

Since the original identification of cytoplasmic estrogen receptors (ER) in human breast cancer (1), rapid progress has been made towards linking presence of the receptor with endocrine responsiveness of the tumor. It is now known that the likelihood of a successful response to endocrine therapy is increased at least 10-fold in patients whose tumors are positive for ER (2). However, not all ER containing tumors respond, and this has led to the concept that ER are necessary but not sufficient markers of hormone dependence.

Keywords

Estrogen Receptor Nuclear Receptor Estrogen Action Nuclear Site Estrogen Receptor Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Jensen, E.V., Block, G.E., Smith, S., Keyser, K., and Desombre, E.R.: Natl. Cancer Inst. Monographs 34, 55–79 (1971)Google Scholar
  2. 2.
    Mcguire, W. L., Carbone, P. P., Sears, M. E. and Escher, G. C.: Estrogen Receptors in Human Breast Cancer. McGuire, W. L., Carbone, P. P. and Vollmer, E. P. (eds.),New York: Raven Press, p. 1–6.Google Scholar
  3. 3.
    Horwitz, K. B., Costlow, M. E., and McGUIRE, W. L.: Steroids 26, 785–795 (1975)Google Scholar
  4. 4.
    Horwitz, K. B., Mcguire, W. L., PEARSON, O. H., and Segaloff, A.: Science 189, 726–727 (1975)Google Scholar
  5. 5.
    Soule, H. D., Vasquez, J., LONG, A., ALBERT, S., and BRENNAN, M. J.: J. Natl. Can. Inst. 51, 1409–1416 (1973)Google Scholar
  6. 6.
    Brooks, S. C., Locke, E. R., and SOULE, H. D.: J. Biol. Chem. 248, 6251–6253 (1973)PubMedGoogle Scholar
  7. 7.
    Lippman, M., BOLAN, G., and HUFF, K.: Cancer Res. 36, 45954601 (1976)Google Scholar
  8. 8.
    Zava, D. T. and Mcguire, W. L.: J. Biol. Chem. 252, 3703–3708 (1977)Google Scholar
  9. 9.
    Zava, D. T., Chamness, G. C., Horwitz, K. B., and Mcguire, W. L.: Science 197, 663–664 (1977)Google Scholar
  10. 10.
    Leavitt, W. W., Chen, T. J., and Allen, T. C.: Ann. N. Y. Acad. Sci. 286, 210–225 (1977)CrossRefGoogle Scholar
  11. 11.
    Horwitz, K. B., and Mcguire, W. L.: J. Biol. Chem. 253, 2223–202228 (1978)Google Scholar
  12. 12.
    Horwitz, K. B., and Mcguire, W. L.: J. Biol. Chem., in press, (1978)Google Scholar
  13. 13.
    Giannopoulos, G., and Gorski, J.: J. Biol. Chem. 246, 2524–2529 (1971)Google Scholar
  14. 14.
    Anderson, J. N., Peck, E. J., JR., and Clark, J. H.: Endocrinology 96, 160–167 (1975)Google Scholar
  15. 15.
    Sherman, M. R., Corval, P. I., and O’malley, B. W.: J. Biol. Chem. 245, 6085–6096 (1970)PubMedGoogle Scholar
  16. 16.
    Faber, L. E., Sandmann, M. L., and Stavely, H. E.: J. Biol. Chem. 247, 5648–5649 (1972)Google Scholar
  17. 17.
    Bayard, F., Damilano, S., Robel, P., and Baulieu, E. E.: C. R. Acad. Sci. (Paris) 281, 1341–1344 (1975)Google Scholar
  18. 18.
    Horwitz, K. B., and Mcguire, W. L.: Cancer Res. 37, 1733–1738 (1977)Google Scholar
  19. 19.
    Sarff, M., and Gorski, J.: Biochemistry 10, 2557–2563 (1971)Google Scholar
  20. 20.
    Williams, D., and GORSKI, J.: Proc. Natl. Acad. Sci. 69, 34643468 (1972)Google Scholar
  21. 21.
    Dehertogh, R., Ekka, E., Vanderheyden, I., and HOET, J. J.: J. Steroid Biochem. 4, 313–320 (1973)Google Scholar
  22. 22.
    Schrader, W. T., Toft, D. O., and O’malley, B. W.: J. Biol. Chem. 247, 2401–2407 (1972)Google Scholar
  23. 23.
    Clark, J. H., and Peck, E. I, JR.: Nature 260, 635–637 (1976)Google Scholar
  24. 24.
    Ruh, T. S., and Baudendistel, L. I: Endocrinology 100, 420–426 (1977)Google Scholar
  25. 25.
    Horwitz, K. B., Koseki, Y., and McGUIRE, W. L.: Endocrinology, in press, (1978)Google Scholar
  26. 26.
    Clark, J.H., Pazko, Z., and Peck, E.J., JR.: Endocrinology 100, 91–96 (1977)Google Scholar
  27. 27.
    Lazier, C.. B., and Alford, W. S.: Biochem. J. 164, 659–667 (1977)Google Scholar
  28. 28.
    Cidlowski, J. A., and Muldoon, T. G.: Biol. of Reprod. 15, 381–398 (1976)CrossRefGoogle Scholar
  29. 29.
    Hardin, J. W., Clark, J. H., Glasser, S. R., and Peck, E. I, JR.: Biochemistry 15, 1370–1374 (1976)Google Scholar
  30. 30.
    Lan, N. C., and Katzenellenbogen, B. S.: Endocrinology 98, 220–227 (1976)Google Scholar
  31. 31.
    Stormshak, F., Leake, R., Wertz, N., and Gorski, J.: Endocrinology 99, 1501–1511 (1976)Google Scholar
  32. 32.
    Clark, J. H., Peck, E. 1, JR., Anderson, J. N.: Nature 251, 446–448 (1974)Google Scholar
  33. 33.
    Katzenellenbogen, B. S., and Ferguson, E. R.: Endocrinology 97, 1–12 (1975)Google Scholar
  34. 34.
    Capony, F. and Rochefort, H.: Molec. Cell. Endocrinol. 3, 233–251 (1975)Google Scholar
  35. 35.
    Katzenellenbogen, B. S., Ferguson, E. R., and Lan, N. C.: Endocrinology 100, 1252–1259 (1977)PubMedCrossRefGoogle Scholar
  36. 36.
    Ferguson, E. R., and Katzenellenbogen, B. S.: Endocrinology 100, 1242–1251 (1977)Google Scholar
  37. 37.
    Mester, J., and Baulieu, E. E.: Biochem. J. 146, 617–623 (1975)Google Scholar
  38. 38.
    Juliano, J. V., and Stancel, G. H.: Biochemistry 15, 916–920 (1976)Google Scholar
  39. 39.
    Clark, J. H., Anderson, J. N., and Peck, E. J., JR.: Steroids 22, 707–718 (1973)Google Scholar
  40. 40.
    Goldberg, I. H., and Friedman, P. A.: Ann. Rev. Biochem. 40, 775–810 (1971)Google Scholar
  41. 41.
    Sobel, H. M., and Jain, S. C.: J. Mol. Biol. 68, 21–34 (1972)Google Scholar
  42. 42.
    Kleiman, L. and Huang, R. C. C.: J. Mol. Biol. 55, 503–521 (1971)Google Scholar
  43. 43.
    Leinwald, L., and Ruddle, F. H.: Science 197, 381–383 (1977)Google Scholar
  44. 44.
    Bastos, R. N. and Aviv, H.: Cell 11, 641–650 (1977)Google Scholar
  45. 45.
    Horwitz, K. B., and Mcguire, W. L.: J. Biol. Chem. 253: 6319–6322 (1978)Google Scholar
  46. 46.
    Palmiter, R. D., Moore, P. B., Mulvihill, E. R., and Emtage, S.: Cell 8, 557–572 (1976)Google Scholar

Copyright information

© Springer Science+Business Media New York 1979

Authors and Affiliations

  • Kathryn B. Horwitz
    • 1
  • William L. McGuire
    • 1
  1. 1.The University of Texas Health Science CenterSan AntonioUSA

Personalised recommendations