Brain Glycoproteins and Inter-Cell Recognition: Tay-Sachs’ Disease and Intraneuronal Recognition

  • Samuel Bogoch
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 19)


In earlier work we demonstrated that the carbohydrate abnormality in Tay-Sachs’ Disease was not confined to the brain gangliosides, but that there was in addition a generalized increase in glycoprotein hexose and hexosamine (4). One glycoprotein fraction, 10B, was found to be markedly increased in concentration. It was noted that this might be a function of the marked gliosis, since there was other evidence that 10B is a glial constituent. In that report, the information functions of the brain glycoproteins was proposed, and in related studies (summarized in reference 1) the general function of brain glycoproteins in intercell recognition was proposed (“Sign-Post” Theory).


Brain Tumor Amino Sugar Glial Tumor Human Brain Tumor Brain Ganglioside 
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Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • Samuel Bogoch
    • 1
  1. 1.Foundation for Research on the Nervous System and Dreyfus Medical FoundationBoston University School of MedicineUSA

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