Gangliosides of CSF and Plasma: Their Relation to the Nervous System

  • R. W. Ledeen
  • R. K. Yu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 19)


The lipid composition of body fluids has become a subject of growing interest in the field of sphingolipidoses and related disorders ever since the recognition that lipid abnormalities which characterize these diseases are often manifested in one or more such fluids. CSF1 has special significance in relation to neurological disorders and some evidence suggests that lipid alterations in this fluid may be correlated with certain categories of disease. Thus, on the basis of one survey Christensen and Matzke (1965) suggested that the ratio of cerebroside to lecithin provides an index of white matter destruction. A detailed study of CSF lipids in multiple sclerosis patients by Tourtel lotte and Haerer (1969) revealed several lipids to be elevated above normal with cerebrosides showing the most characteristic increase. Hagberg and Svennerholm (1960) detected sulfatides in the CSF of patients with late infantile metachromatic leucodystrophy but did not quantify or compare them with normal levels.


Sialic Acid Bovine Plasma Brain Ganglioside Total Sialic Acid Cerebellar Astrocytoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • R. W. Ledeen
    • 1
  • R. K. Yu
    • 1
  1. 1.Saul R. Korey Department of Neurology and Department of BiochemistryAlbert Einstein College of MedicineBronxUSA

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