Brain Gangliosides in Krabbe Disease

  • Lars Svennerholm
  • Marie-Thérèse Vanier
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 19)


Infantile globoid cell leucodystrophy (GLD) or Krabbe disease is considered to be a rare genetic disease, but in Scandinavia at the present time it is the most common form of the sphingolipidoses. In 1963 we published clinical neuropathological, and biochemical studies of six cases (Hagberg et al., 1963) and more recently Hagberg et al. (1969) reported clinical and genetic studies of 32 Swedish cases collected during a 15-year period. Autopsy material from 12 representative cases from this study, and from 5 new cases, has been used in the present biochemical study.


White Matter Cerebral Cortex Alditol Acetate Subacute Sclerosing Panencephalitis Brain Ganglioside 
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Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • Lars Svennerholm
    • 1
  • Marie-Thérèse Vanier
    • 2
  1. 1.Department of Neurochemistry, Psychiatric Research CentreUniversity of GöteborgGöteborgSweden
  2. 2.Hôpital Sainte-EugénieLyonFrance

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