Liver Glycolipids, Steroid Sulfates and Steroid Sulfatases in a Form of Metachromatic Leukodystrophy Associated with Multiple Sulfatase Deficiencies

  • H. W. Moser
  • M. Sugita
  • M. D. Harbison
  • M. Williams
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 19)


Austin et al. (4) and Mehl and Jatzkewitz et al. (14,22) have shown that metachromatic leukodystrophy (MLD) is associated with deficient activity of arylsulfatase A. This enzyme, in combination with a heat-stable complementary factor, cleaves sulfate from sulfatide.(22,23) Arylsulfatase A deficiency thus causes the sulfatide accumulation which is pathognomic of this disease.


Maple Syrup Urine Disease Metachromatic Leukodystrophy Sandhoff Disease Estrone Sulfate Steroid Sulfatase 
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Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • H. W. Moser
    • 1
  • M. Sugita
    • 1
  • M. D. Harbison
    • 1
  • M. Williams
    • 1
  1. 1.The Eunice Kennedy Shriver Center at the Walter E. Fernald State SchoolWaverleyUSA

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