Chemical Pathology of Tay-Sachs Disease in the Fetus

  • Larry Schneck
  • Masazumi Adachi
  • Bruno W. Volk
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 19)


Prenatal diagnosis of Tay-Sachs disease not only offers a means for effective pregnancy management, but it also provides a unique opportunity to study the disease early in fetal development (1). This paper will describe some of the chemical features of three cases of fetal Tay-Sachs disease (2). It will also include some preliminary studies on enzyme replacement with cultured fetal Tay-Sachs disease fibroblasts.


Sialic Acid Amniotic Fluid Prenatal Diagnosis Phosphatidic Acid Chemical Pathology 
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  1. 1.
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Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • Larry Schneck
    • 1
  • Masazumi Adachi
    • 1
  • Bruno W. Volk
    • 1
  1. 1.Isaac Albert Research Institute of the Kingsbrook Jewish Medical. Center and the Department of NeurologyKingsbrook Jewish Medical Center, and Veterans Administration HospitalBrooklynUSA

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