The Chemical Pathology of Tay-Sachs Disease

  • Konrad Sandhoff
  • Horst Jatzkewitz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 19)

Abstract

In his review on sphingolipidoses (1) which appeared in the New England Journal of Medicine in 1966, R.O. Brady predicted that a sphingolipodystrophy remains to be discovered where abnormal quantities of the entire globoside molecule might accumulate because of attenuation of a hexosaminidase that catalyses the hydrolysis of the terminal N-acetylgalactosamine.

Keywords

Sodium Taurocholate Neuraminic Acid Chemical Pathology Isoelectric Focussing Storage Pattern 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • Konrad Sandhoff
    • 1
  • Horst Jatzkewitz
    • 1
  1. 1.Max-Planck-Institut für PsychiatrieNeurochemische AbteilungMünchenGermany

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