Radioactive Precursor Incorporation into Lipids of Humans with Cerebral Lipidoses:1-14C-Glucosamine, U3H-Serine, and 3H-Acetate

  • Robert M. Burton
  • S. Handa
  • R. E. Howard
  • T. Vietti
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 19)


Our laboratory as part of the Beaumont-May Institute of Neurology has long been interested in hereditary neurological diseases in humans and in the study of the normal development of the nervous system. These latter studies have been employing small animals primarily the rat and, in a few instances, the rhesus monkey and minipig. Recently, some of our results on the metabolism of glycolipids have been summarized in a review entitled “Factors affecting Incorporation of Precursors into body constituents — A review of common sense considerations with glycolipids or examples” (2). In an effort to translate the information gained from laboratory animal experiments to the human and to gain further insight into human cerebral lipidosis, we have entered a long term collaborative study with a number of departments at Washington University Medical School and St. Louis Children’s Hospital. Our objectives are to make and correlate studies of the clinical, pathological, electron microscopic and biochemical aspects of hereditary neurological diseases.


Neuraminic Acid Radioactive Precursor Laboratory Animal Experiment Body Constituent Hereditary Neurological Disease 
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Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • Robert M. Burton
    • 1
  • S. Handa
    • 2
  • R. E. Howard
    • 3
  • T. Vietti
    • 1
  1. 1.Departments of Pharmacology, Pediatrics, and Pathology and The Beaumont-May Institute of NeurologyWashington University Medical SchoolSt. LouisUSA
  2. 2.Biochemistry Dept.Tokyo UniversityJapan
  3. 3.Pathology Dept.Texas UniversitySan AntonioUSA

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