Effect of Amino Acid Imbalance on Polyribosome Profiles and Protein Synthesis in Fetal Cerebral Cortex

  • Paul W. K. Wong
  • Parvin Justice
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 19)


Numerous “inborn errors” of amino acid metabolism have been described (15,22). Most of these are associated with clinical disease of varying severity. For example, while maple syrup urine disease is usually rapidly fatal (14) phenylketonuria is competible with relative longevity (10). In most instances, the inherited metabolic block in the amino acid(s) involved has been well defined. However, the pathogensis of the various clinical syndromes is less well delineated.


Amino Acid Metabolism Fetal Brain Amino Acid Concentration Maternal Plasma Maple Syrup Urine Disease 
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Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • Paul W. K. Wong
    • 1
    • 2
  • Parvin Justice
    • 1
    • 2
  1. 1.The Infants’ Aid Perinatal Research LaboratoriesMount Sinai Hospital, the Chicago Medical SchoolUSA
  2. 2.Department of Pediatrics, Stritch School of MedicineLoyola University of ChicagoUSA

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