Novel Magnetic Microcarriers on the Basis of Poly(Vinyl Alcohol) for Biomedical Analysis

  • Detlef Müller-Schulte
  • Frank Füssl
  • Marcel De Cuyper


Novel magnetic microspheres based on poly(vinyl alcohol) (PVA) were synthesized using a water-in-oil-suspension technique. The preparation method enables bead sizes from 1 to 1000 µm and represents a simple procedure requiring only a fraction of the time and effort usually necessary for the synthesis of magnetic beads. The unique hydrogel-like structure of PVA offers a high chemical functionality comparable to that of the well known agarose gels. The applicability of the new beads was demonstrated by two tests: (i) an immunoadsorption test to remove blood group antibodies from human plasma using blood group antigen coated beads and (ii) the binding of biotinylated albumin to differently coated avidin beads. The tests revealed a good binding performance for both carriers. The relationship between the binding capacity of the biotin probe and the avidin coupling mode is explained in more detail.


Magnetic Bead Vinyl Alcohol High Performance Liquid Chro Bead Size High Performance Liquid Chro 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Detlef Müller-Schulte
    • 1
  • Frank Füssl
    • 1
  • Marcel De Cuyper
    • 2
  1. 1.RWTH AachenInstitut für Anorganische ChemieAachenGermany
  2. 2.Campus KortrijkKatholieke Universiteit LeuvenKortrijkBelgium

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