Skip to main content
SpringerLink
Log in
Book cover

Scientific and Clinical Applications of Magnetic Carriers pp 353–357Cite as

Ferromagnetic and Immunomagnetic Concentration of Mycobacteria for the Diagnosis of Tuberculosis

  • Chapter

  • 459 Accesses

Abstract

A magnetic separation method for the concentration of tuberculosis bacteria and its application for the diagnosis of tuberculosis in clinical trials in Russia is described. Magnetic particles were developed which selectively bind to tuberculosis bacilli. The tuberculosis cells attached to the particles can be extracted by a centrifuge or a magnetic separator. The detection of the bacteria was then possible by either traditional microscopic and microbiological methods or molecular diagnostic techniques (PCR). The magnetic method was almost as sensitive in diagnosing tuberculosis as the much more time and work intensive cultivation method.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Sjobring Jet al. (1990). J. Clin. Microbiol. 28, 2200–2204.

    Google Scholar 

  2. Polozov A et al. (1991). Problemy Tuberkuloza 9, 61–63.

    Google Scholar 

  3. Vladimirsky MA, Kuznetsov AA, Filippov VI (1993). J. Magnet. and Magn. Materials 122, 371–373.

    Google Scholar 

  4. Kronic P and Gilpin RW (1986). Biochem. Biophys. Meth. 12, 56–58.

    Google Scholar 

  5. Yu H and Bruno JG (1996). Appl. Environ. 62, 587–592.

    Google Scholar 

  6. Malashin SI, Dodrinsky EK et al (1989). Proceed. 3rd Conference on Application of Magn. Liq. in Biol. and Med., Sukhumi, 112–113.

    Google Scholar 

  7. Strumban EE, Dobrinsky EK, Kuznetsov AA, Harrutyunyan AR (1977). Method and apparatus for making carbon-encapsulated ultrafine metal particles. US Patent 5, 593, 740.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Synmatix Corporation, 26677 West 12 Mile Road, Southfield, Michigan, 48034, USA

    Michael A. Vladimirsky, Anatoly A. Kuznetsov & Alexander I. Polozov

  2. Russian Research Institute of Phtisiopulmonology, Moscow, Russia

    Victor I. Philippov & Edward K. Dobrinsky

  3. Institute of Biochemical Physics, Russian Academy of Sciences, Kosygin St. 4, Moscow, 117977, Russia

    Michael A. Vladimirsky, Victor I. Philippov, Anatoly A. Kuznetsov, Alexander I. Polozov & Edward K. Dobrinsky

Authors
  1. Michael A. Vladimirsky
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Victor I. Philippov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Anatoly A. Kuznetsov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Alexander I. Polozov
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Edward K. Dobrinsky
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Urs Häfeli  & Maciej Zborowski  & 

  2. University of Rostock, Rostock, Germany

    Wolfgang Schütt

  3. micro caps, Rostock, Germany

    Joachim Teller

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer Science+Business Media New York

About this chapter

Cite this chapter

Vladimirsky, M.A., Philippov, V.I., Kuznetsov, A.A., Polozov, A.I., Dobrinsky, E.K. (1997). Ferromagnetic and Immunomagnetic Concentration of Mycobacteria for the Diagnosis of Tuberculosis. In: Häfeli, U., Schütt, W., Teller, J., Zborowski, M. (eds) Scientific and Clinical Applications of Magnetic Carriers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6482-6_26

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-6482-6_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-3283-9

  • Online ISBN: 978-1-4757-6482-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation