Abstract
The knowledge and controlled exploitation of the basic mechanisms determining the organ distribution of i.v. injected particles could be used to target diagnostics and colloidal drug carriers to their desired site of action. Basic studies with indifferent model particles (polystyrene latex) have been performed and the results are, at present, being transferred to magnetite particles used in magnet resonance imaging (MRI). In earlier experiments, it was possible to explain the basic mechanisms leading to a specific organ distribution of intravenously injected particles by just considering their physicochemical properties. However, a straight correlation between physicochemical data and organ distribution could not be established. For example, 60 nm polystyrene particles surface-modified by the adsorption of two different block-copolymers differed only slightly in their physicochemical characterisation data but showed a completely different organ distribution. This led to today’s paradigm that the key factor for the in vivo behaviour of particles is the interaction of the injected particles with plasma proteins. For the analysis of plasma protein adsorption, two-dimensional electrophoresis was established and successfully applied to the analysis of diagnostic magnetic particles used in MRI. As a new approach for the site-specific enrichment of particles, the concept of “differential protein adsorption” was developed.
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Müller, R.H., Lück, M., Harnisch, S., Thode, K. (1997). Intravenously Injected Particles. In: Häfeli, U., Schütt, W., Teller, J., Zborowski, M. (eds) Scientific and Clinical Applications of Magnetic Carriers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6482-6_10
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DOI: https://doi.org/10.1007/978-1-4757-6482-6_10
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