Regulation of G-Protein Coupled Receptor Cytosolic mRNA Binding Proteins

  • Kathryn Sandberg
  • Zheng Wu
  • Hong Ji
  • Eric Hernandez
  • Susan E. Mulroney
Part of the Endocrine Updates book series (ENDO, volume 16)


The regulation of G-protein coupled receptor (GPCR) expression is an area of intense interest because GPCRs play a crucial role in many key physiological and pathological processes. Indeed, greater than 60% of all pharmaceuticals are targeted towards GPCRs. The ability to regulate GPCR protein expression at the post-transcriptional level provides a mechanism past the transcriptional regulatory point when genes are turned on or off. This allows a finer control of expression for the GPCRs that are critically involved in a myriad of critical cell functions such as growth, differentiation, and development. In the majority of instances of post-transcriptional regulation, the binding of specific proteins to defined sequences and/or structures in the target mRNA, governs splicing, nucleocytoplasmic transport, subcellular localization, translation and mRNA degradation. In this chapter, we focus on the regulation of GPCRs via cytosolic RNA binding proteins that, through interaction with specific sequences or structures in the mRNA, contribute to determining the level of protein expression by altering the rate of mRNA translation or its stability. Highlighted are our studies on RNA binding proteins that interact with the 5’ leader sequence of the angiotensin AT1 receptor, a GPCR that is critical to the control of blood pressure and fluid homeostasis.


mRNA Stability Receptor mRNA Homeostatic Regulation Cell BioI mRNA Decay Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Kathryn Sandberg
    • 1
  • Zheng Wu
    • 1
  • Hong Ji
    • 1
  • Eric Hernandez
    • 1
  • Susan E. Mulroney
    • 1
  1. 1.Georgetown University School of MedicineUSA

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