Hormonal Regulation of the EGF/Receptor System

  • Stephen W. Spaulding
  • Lowell G. Sheflin
Part of the Endocrine Updates book series (ENDO, volume 16)


The EGF/receptor system is involved in the development, maintenance and repair of various organs, particularly those involving ductal systems. Disruptions of the EGF/receptor system have been implicated in a variety of clinical disorders including cancer and aging. Some hormones alter the expression of EGF ligands, EGF receptors and of downstream factors that mediate EGF receptor action during development. These hormonal effects vary according to the species, organ and stage of development under study. Androgens alter EGF mRNA levels in several rodent tissues, yet no androgen-responsiveness is detectable within 7 kB upstream of the promoter of the EGF gene, which supports earlier evidence that androgens have post-transcriptional actions on EGF expression. AU-rich elements that can influence transcript stability and subcellular localization are present in the 3’ UTR of EGF mRNA. Androgens regulate EGF mRNA polyadenylation site usage, poly-A tail length and mRNA stability in the mouse submaxillary salivary gland (SMG) but not in the kidney, although androgens do regulate other genes in the kidney. Androgens also regulate the levels of several AU-rich RNA binding proteins known to affect the subcellular localization, translation and stability of AU-rich mRNAs. Androgen-dependent changes in the subcellular levels of these RNA binding proteins also indicate a causal connection with the androgen-dependent changes in EGF mRNA and its translation.


Epidermal Growth Factor Receptor Granular Convoluted Tubule Granular Convoluted Tubule Cell Epidermal Growth Factor Gene AUFI Isoforms 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Stephen W. Spaulding
    • 1
  • Lowell G. Sheflin
    • 1
  1. 1.VA Western New York and SUNY at BuffaloBuffaloUSA

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