Site-Specific Cleavage of Insulin-Like Growth Factor II mRNAs

  • Erwin L. van Dijk
  • P. Elly Holthuizen
Part of the Endocrine Updates book series (ENDO, volume 16)


Insulin-like growth factor II (IGF-II) is a protein involved in growth and differentiation of numerous cell types. Because of the importance of IGF-II in many different processes, various regulatory mechanisms are available in the cell to control IGF-II protein synthesis, reflecting the vital importance of fine tuning and rapid regulation of IGF-II mRNA levels and IGF-II protein amount. One such mechanism is the site-specific endonucleolytic cleavage of IGF-II mRNAs, which will be described in this chapter. The role of an RNA-binding protein that is associated with the highly structured RNA will be discussed as well as the requirements for recognition of the IGF-II mRNA by an endoribonuclease.


Cleavage Site Cleavage Product Chicken Embryo Fibroblast Homeostatic Regulation Cleavage Efficiency 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Erwin L. van Dijk
    • 1
  • P. Elly Holthuizen
    • 2
  1. 1.Centre de Genetique MoleculaireGif-sue-Yvette, CedexFrance
  2. 2.University Medical Center UtrechtUtrechtThe Netherlands

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