Intraspecies Extrapolation: Efforts at Enhancing Dose-Response Relationships

  • Janice Longstreth
Part of the Advances in Risk Analysis book series (AIRA, volume 5)


I think that it is safe to say that the process of assessing the human health risk posed by exposure to toxic chemicals is far more often based on animal toxicity data than on human data. That being the case, those who perform such risk assessments (myself included) are often faced with the need to extrapolate from animal data to estimates of human risk. This requirement for intraspecies extrapolation has been around a long time and is the practical basis for toxicology; unfortunately, it is fraught with uncertainty because of the large number of assumptions normally required due most frequently to insufficient information.


Stratum Corneum Benzyl Alcohol Human Health Risk Assessment Respiratory Minute Volume Vinyl Bromide 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Janice Longstreth
    • 1
  1. 1.ICF — Clement, Inc.USA

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