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Blood Cholinesterases as Human Biomarkers of Organophosphorus Pesticide Exposure

  • Herbert N. Nigg
  • James B. Knaak
Part of the Reviews of Environmental Contamination and Toxicology book series (RECT, volume 163)

Abstract

The organophosphorus (OP) insecticides were developed before and during World War II. The history of their development has been reviewed (Holmstedt 1963; Karczmar 1970; Ursdin 1970; Koelle 1981). In 1936, Schrader synthesized paraoxon, parathion, and octamethylpyrophosphoramide (OMPA, schradan) in a search for an effective cockroach control agent (Ursdin 1970). Parathion use in agriculture began after World War II. In 1949, a mixer loader was killed by parathion in Lake Placid, FL (Griffiths et al. 1951). Monitoring red blood cell acetyl-cholinesterase (RBC AChE) of exposed workers was begun in 1950 in the Florida citrus industry (Griffiths et al. 1951), perhaps the first use of human blood esterase monitoring in agriculture.

Keywords

PBPK Model Methyl Parathion Organophosphorus Pesticide Plasma Cholinesterase Brain AChE 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Herbert N. Nigg
    • 1
  • James B. Knaak
    • 2
  1. 1.Citrus Research and Education CenterUniversity of FloridaLake AlfredUSA
  2. 2.Department of Pharmacology and Toxicology, School of MedicineSUNY at BuffaloBuffaloUSA

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