Plasticity Mechanisms Underlying mGluR-Induced Epileptogenesis

  • Robert K. S. Wong
  • Shih-Chieh Chuang
  • Riccardo Bianchi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 548)


Transient application of group I metabotropic glutamate receptor (mGluR) agonists to hippocampal slices produces ictal-like discharges that persist for hours after the removal of the agonist. This effect of group I mGluR stimulation—converting a ‘normal’ hippocampal slice into an ‘epileptic-like’ one—may represent a form of epileptogenesis. Because this epileptogenic process can be induced in vitro and it occurs within hours, it has been possible to examine the cellular and transduction processes underlying the generation and long-term maintenance of ictal-like bursts. ImctuR(v) a voltage-dependent depolarizing current activated by group I mGluR agonists, appears to play an important role in the expression of the ictal-like bursts. Long-term activation of ImG1uR(v) following mGluR stimulation is a possible plastic change that enables the long-term maintenance of ictal discharges. Induction of ImGltaz(v) may represent a cellular event underlying the mGluR-induced epileptogenesis.


Pyramidal Cell Hippocampal Slice Metabotropic Glutamate Receptor Epileptiform Discharge Plasticity Mechanism 
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© Springer Science+Business Media New York 2004

Authors and Affiliations

  • Robert K. S. Wong
  • Shih-Chieh Chuang
  • Riccardo Bianchi

There are no affiliations available

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