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The Role of BDNF in Epilepsy and Other Diseases of the Mature Nervous System

  • Chapter
Recent Advances in Epilepsy Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 548))

Abstract

The neurotrophin brain-derived neurotrophic factor (BDNF) is ubiquitous in the central nervous system (CNS) throughout life. In addition to trophic effects on target neurons, BDNF appears to be part of a general mechanism for activity-dependent modification of synapses in the developing and adult nervous system. Thus, diseases of abnormal trophic support (such as neurodegenerative diseases) and diseases of abnormal excitability (such as epilepsy and central pain sensitization) can be related in some cases to abnormal BDNF signaling. For example, various studies have shown that BDNF is upregulated in areas implicated in epileptogenesis, and interference with BDNF signal transduction inhibits the development of the epileptic state. Further study of the cellular and molecular mechanisms by which BDNF influences cell survival and excitability will likely provide novel concepts and targets for the treatment of diverse CNS diseases.

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Authors
  1. Devin K. Binder
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Editors and Affiliations

  1. Department of Neurological Surgery, Moffitt Hospital, University of California at San Francisco, San Francisco, California, USA

    Devin K. Binder

  2. Center for Neural Recovery and Rehabilitation Research, New York State Department of Health, Helen Hayes Hospital, West Haverstraw, New York, USA

    Helen E. Scharfman

  3. Departments of Pharmacology and Neurology, Columbia University, New York, New York, USA

    Helen E. Scharfman

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Binder, D.K. (2004). The Role of BDNF in Epilepsy and Other Diseases of the Mature Nervous System. In: Binder, D.K., Scharfman, H.E. (eds) Recent Advances in Epilepsy Research. Advances in Experimental Medicine and Biology, vol 548. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6376-8_3

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