The History of Controlled Trials

  • Christopher J. Bulpitt
Part of the Developments in Biostatistics and Epidemiology book series (DBEP, volume 1)


The first well documented randomised controlled trial of medical treatment may have been that organised by the Medical Research Council and reported in 1948 [3]. However, Rose and Armitage have described a possible RCT dating from 1662 [5] and R.A. Fisher introduced randomised trials into agricultural research in 1920.


Rheumatic Fever Empty Stomach Century Inoculation Lemon Juice Smallpox Inoculation 
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Copyright information

© Springer Science+Business Media Dordrecht 1983

Authors and Affiliations

  • Christopher J. Bulpitt
    • 1
    • 2
    • 3
  1. 1.Department of Medical Statistics and EpidemiologyLondon School of Hygiene and Tropical MedicineLondonUK
  2. 2.Royal Postgraduate Medical SchoolLondonUK
  3. 3.Hammersmith HospitalLondonUK

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