Type 1 Diabetes Mellitus: Epidemiology, Genetics, Pathogenesis And Clinical Manifestations

  • Marian Rewers


Type 1 diabetes is caused by pancreatic β-cell destruction that leads to loss of insulin secretion and absolute insulin deficiency. Type 1 diabetes accounts for about 10% of all diabetes, affecting approximately 1.4 million people in the U.S., and 10–20 million globally.1 Diabetes is one of the most common severe chronic diseases of childhood affecting 1 in 300 children and as many as 1 in 100 adults during the life span.2


Glutamic Acid Decarboxylase United Kingdom Prospective Diabetes Study Islet Cell Antibody Congenital Rubella Syndrome Islet Autoimmunity 
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© Springer Science+Business Media New York 2004

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  • Marian Rewers

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