Polycystic Ovary Syndrome

  • Susan B. Zweig
  • Marsha C. Tolentino
  • Leonid Poretsky


Polycystic ovary syndrome (PCOS) is a common disorder affecting (depending on the population studied and the definition of the syndrome) between 5 to 20% of reproductive age women.1 If the middle of this range is considered as a realistic prevalence, then PCOS may be the most prevalent endocrine disorder in women. In spite of the widespread presence of PCOS, its precise definition still eludes both investigators and practitioners. Most consensus definitions describe PCOS as a disorder characterized by chronic anovulation and the presence of some degree of hyperandrogenism, with the exclusion of specific disorders that may lead to similar phenotypes, particularly, 21-hydroxylase deficiency and other forms of congenital adrenal hyperplasia. The definition proposed in 1990 by the National Institutes of Health Conference on PCOS requires a minimum of two criteria: menstrual abnormalities due to oligo- or anovulation, and hyperandrogenism of ovarian origin. Other disorders, such as 21-hydroxylase deficiency, androgen secreting tumors, and hyperprolactinemia, must be excluded.2


Insulin Resistance Insulin Receptor Polycystic Ovary Polycystic Ovary Syndrome Congenital Adrenal Hyperplasia 
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© Springer Science+Business Media New York 2004

Authors and Affiliations

  • Susan B. Zweig
  • Marsha C. Tolentino
  • Leonid Poretsky

There are no affiliations available

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