Peripheral Vascular Disease in Diabetes
Diabetes mellitus is a ubiquitous disease which affects millions of Americans, incurs significant comorbidities and costs billions annually in healthcare dollars. The morbidities associated with diabetes mellitus include a substantial increase in both small vessel (microvascular) and large vessel (macrovascular) disease. The macrovascular effects of diabetes, causing serious morbidity and mortality, are found in the coronary, cerebral (extra and intracranial) and peripheral vascular circulation. The focus of this chapter’s discussion will be on the lower extremity peripheral vascular complications of diabetes.
KeywordsPeripheral Vascular Disease Limb Salvage Great Saphenous Vein Rest Pain Major Amputation
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- 5.Current therapy in vascular surgery. Ernst-Stanley, Ed, 3`a edition, 1995.Google Scholar
- 6.Cohen RA. Dysfunction of vascular endothelium in diabetes mellitus. Circulation 87: 67–76, 1993.Google Scholar
- 14.Wolff SP, Dean RT. Glucose autoxidation and protein modification: the role of oxidative glycosylation in diabetes. Biochem J 245: 234–50, 1987.Google Scholar
- 16.Vascular Surgery: A comprehensive review. Wesley S. Moore, Ed., 5th ed., W.B. Saunders Co., Philadelphia, PA.Google Scholar
- 17.Vascular disease: a multi-specialty approach to diagnosis and management Darwin Eton, Fred Weaver, Ed. Landes Bioscience, 1998.Google Scholar
- 20.Vascular, Medicine: A textbook of vascular biology and diseases Loscalzo J, Creager MA, Dzau VJ, Eds; 2nd ed., Little, Brown, 1996.Google Scholar