Maturity-Onset Diabetes of the Young: Molecular Genetics, Clinical Manifestations and Therapy

  • Markus Stoffel


Type 2 diabetes accounts for ≥90% of all diabetes. It ranks among the top ten causes of death in western nations and afflicts about 5% of populations in industrialized countries. Type 2 diabetes is a heterogeneous, complex metabolic syndrome in which hyperglycemia results from decreased insulin effectiveness (insulin resistance) and an impaired insulin secretory response to glucose. Genetic and lifestyle factors (e.g. weight, physical activity) predispose to the development of these defects, however, the genetic mechanisms that underlie the pathophysiology of most forms of type 2 diabetes are not completely understood.


Hepatocyte Nuclear Factor Glutamic Acid Decarboxylase Antibody Visceral Endoderm Insulin Secretion Rate Pancreatic Agenesis 
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© Springer Science+Business Media New York 2004

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  • Markus Stoffel

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