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Principles of Diabetes Mellitus pp 201–220Cite as

Maturity-Onset Diabetes of the Young: Molecular Genetics, Clinical Manifestations and Therapy

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Abstract

Type 2 diabetes accounts for ≥90% of all diabetes. It ranks among the top ten causes of death in western nations and afflicts about 5% of populations in industrialized countries. Type 2 diabetes is a heterogeneous, complex metabolic syndrome in which hyperglycemia results from decreased insulin effectiveness (insulin resistance) and an impaired insulin secretory response to glucose. Genetic and lifestyle factors (e.g. weight, physical activity) predispose to the development of these defects, however, the genetic mechanisms that underlie the pathophysiology of most forms of type 2 diabetes are not completely understood.

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Authors
  1. Markus Stoffel
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Editors and Affiliations

  1. Division of Endocrinology, Beth Israel Medical Center, New York, New York, USA

    Leonid Poretsky M.D. (Chief, Professor of Medicine) (Chief, Professor of Medicine)

  2. Albert Einstein College of Medicine, New York, New York, USA

    Leonid Poretsky M.D. (Chief, Professor of Medicine) (Chief, Professor of Medicine)

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Stoffel, M. (2004). Maturity-Onset Diabetes of the Young: Molecular Genetics, Clinical Manifestations and Therapy. In: Poretsky, L. (eds) Principles of Diabetes Mellitus. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6260-0_11

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  • DOI: https://doi.org/10.1007/978-1-4757-6260-0_11

  • Publisher Name: Springer, Boston, MA

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