Preventive Nutrition and Lung Cancer

  • George W. Comstock
  • Kathy J. Helzlsouer
Part of the Nutrition ◊ and ◊ Health book series (NH)


In searching for the causes of any cancer, it is natural to think first of substances that come into direct contact with the organs and cells that are involved. For lung cancer, the early suspects were smokes, dusts, and gases, particularly smoke from burning tobacco; dusts containing carcinogens, such as arsenic or asbestos; and radon gas. At present, these and other airborne substances have become accepted carcinogens (1). Tobacco smoke is by far the most important because of the intensity, prevalence, and ubiquity of exposures to this complex mixture of known and suspected toxins and carcinogens.


Lung Cancer Beta Carotene Lung Cancer Risk Serum Selenium Develop Lung Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Doll R. Introduction and overview. In: Epidemiology of Lung Cancer. Samet JM, ed. New York: Marcel Dekker, Inc. 1994, 1–14.Google Scholar
  2. 2.
    Churg A. Lung cancer cell type and occupational exposure. In: Epidemiology of Lung Cancer. Samet JM, ed. New York: Marcel Dekker, Inc., 1994, pp. 413–436.Google Scholar
  3. 3.
    Fehily AM, Phillips KM, Yarnell JWG. Diet, smoking, social class, and body mass index in the Caerphilly Heart Disease Study. Am J Clin Nutr 1984; 40:827–833.Google Scholar
  4. 4.
    Sidney S, Caan BJ, Friedman GD. Dietary intake of carotene in nonsmokers with and without passive smoking at home. Am J Epidemiol 1989; 129:1305–1309.Google Scholar
  5. 5.
    Morabia A, Wynder EL. Dietary habits of smokers, people who never smoked, and exsmokers. Am J Clin Nutr 1990; 52:933–937.Google Scholar
  6. 6.
    Subar AF, Harlan LC, Mattson ME. Food and nutrient intake differences between smokers and nonsmokers in the US. Am J Public Health 1990• 80:1323–1329.CrossRefGoogle Scholar
  7. 7.
    Cade JE, Margetts BM. Relationships between diet and smoking-Is the diet of smokers different? J Epidemiol Community Health 1991; 45:270–272.CrossRefGoogle Scholar
  8. 8.
    La Vecchia C, Negri E, Franceschi S, Parazzini F, Decarli A. Differences in dietary intakes with smoking, alcohol, and education. Nutr Cancer 1992; 17:297–304.CrossRefGoogle Scholar
  9. 9.
    Hulsholf KFAN, Wedel M, Löwik MRH, Kok FJ, Kistemaker C, Hermus RJJ, ten Hoor F, Ockhuizen T. Clustering of dietary variables and other lifestyle factors (Dutch Nutritional Surveillance System). J Epidemiol Community Health 1992; 46:417–424.CrossRefGoogle Scholar
  10. 10.
    Järvinen R, Knekt P, Seppänen R, Reunanen A, Heliövaara M, Maatela J, Aromaa A. Antioxidant vitamins in the diet: relationships with other personal characteristics in Finland. J Epidemiol Community Health 1994; 48:549–554.CrossRefGoogle Scholar
  11. 11.
    Matanoski G, Kanchanaraksa S, Lantry D, Chang Y. Characteristics of nonsmoking women in NHANES I and NHANES II epidemiologic follow-up study with exposure to spouses who smoke. Am J Epidemiol 1995; 142:149–157.Google Scholar
  12. 12.
    McMichael AJ, Jensen OM, Parkin DM, Zaridze DG. Dietary and endogenous cholesterol and human cancer. Epidemiol Rev 1984; 6:192–216.Google Scholar
  13. 13a.
    Steinmetz KA, Potter JD. Vegetables, fruit, and cancer. I. Epidemiology. Cancer Causes Control 1991; 2:325–357.CrossRefGoogle Scholar
  14. 13b.
    Ziegler RG, Mayne ST, Swanson CA. Nutrition and cancer. Cancer Causes Control 1966; 7:157–177.CrossRefGoogle Scholar
  15. 14.
    Wolbach SB, Howe PR. Tissue changes following deprivation of fat-soluble A vitamin. J Exp Med 1925; 42:753–777.CrossRefGoogle Scholar
  16. 15.
    Pearce ML, Dayton S. Incidence of cancer in men on a diet high in polyunsaturated fat. Lancet 1971; 1:464–467.CrossRefGoogle Scholar
  17. 16.
    Byers TE, Graham S, Haughey BP, Marshall JR, Swanson MK. Diet and lung cancer risk: findings from the Western New York Study. Am J Epidemiol 1987: 125:351–363.Google Scholar
  18. 17.
    Goodman MT, Kolonel LN, Yoshizawa CN, Hankin JH. The effect of dietary cholesterol and fat on the risk of lung cancer in Hawaii. Am J Epidemiol 1988; 128:1241–1255.Google Scholar
  19. 18.
    Jain M, Burch JD, Howe GR, Risch HA, MillerAB. Dietary factors and risk of lung cancer: results from a case-control study, Toronto, 1981–1985. Int J Cancer 1990; 45:287–293.CrossRefGoogle Scholar
  20. 19.
    Stockwell HG, Candelora EC. Re: Dietary cholesterol and incidence of lung cancer: the Western Electric Study (letter). Am J Epidemiol 1992; 136:1167.Google Scholar
  21. 20.
    Shekelle RB, RossofAH, Stamler J. Dietary cholesterol and incidence of lung cancer: the Western Electric Study. Am J Epidemiol 1991; 134:480–484.Google Scholar
  22. 21.
    Heilbrun LK, Nomura AMY, Stemmennan GN. Dietary cholesterol and lung cancer risk among Japanese men in Hawaii. Am J Clin Nutr 1984; 39:375–379.Google Scholar
  23. 22.
    Knekt P, Seppanen R, Jarvinen R, Virtarno J, Hyvonen L, Pukkala E, Teppo L. Dietary cholesterol, fatty acids, and the risk of lung cancer among men. Nutr Cancer 1991; 16:267–275.CrossRefGoogle Scholar
  24. 23a.
    Hiatt RA, Fireman BH. Serum cholesterol and the incidence of cancer in a large cohort. J Chron Dis 1986: 39:861–870.CrossRefGoogle Scholar
  25. 23b.
    Steenland, K, Nowlin S. Palu S. Cancer incidence in the National Health and Nutrition Survey I followup data: diabetes, cholesterol, pulse, and physical activity. Cancer Epidemiol Biomarkers Prev 1995; 4:807–811.Google Scholar
  26. 24.
    Report of the Committee of Principal Investigators. WHO cooperative trial on primary prevention of ischaemic heart disease with clofibrate to lower serum cholesterol: final mortality follow-up. Lancet 1984; 2:600–604.Google Scholar
  27. 25.
    The Multiple Risk Factor Intervention Trial Research Group. Mortality rates after 10.5 years for participants in the Multiple Risk Factor Intervention Trial. Findings related to a priori hypotheses of the trial. JAMA 1990; 263:1795–1801.CrossRefGoogle Scholar
  28. 26.
    Frick MH, Elo O, Haapa K, Heinonen OP, Heinsalmi P, Helo P, et al. Helsinki Heart Study: primaryprevention trial with gemfibrozil in middle-aged men with dyslipidemia. New Engl J Med 1987; 317:1237–1245.CrossRefGoogle Scholar
  29. 27.
    Multiple Risk Factor Intervention Trial Research Group. Multiple Risk Factor Intervention Trial. Risk factor changes and mortality results. JAMA 1982; 248:1465–1477.CrossRefGoogle Scholar
  30. 28.
    Lipid Research Clinics Program. The Lipid Research Clinics Coronary Primary Prevention Trial results. 1. Reduction incidence of coronary heart disease. JAMA 1984; 251:351–364.Google Scholar
  31. 29.
    Gantt RC, Lincoln JE. Dietary factors and cancer (letter). Int J Epidemiol 1988; 17:231, 232.Google Scholar
  32. 30.
    Taioli E, Nicolosi A, Wynder EL. Possible role of diet as a host factor in the aetiology of tobacco-induced lung cancer: An ecological study in southern and northern Italy. Int J Epidemiol 1991; 20:611–614.CrossRefGoogle Scholar
  33. 31.
    Byers T, Vena J, Mettlin C, Swanson M, Graham S. Dietary vitamin A and lung cancer risk: an analysis by histologic subtypes. Am J Epidemiol 1984; 120:769–776.Google Scholar
  34. 32.
    Alavanja MCR, Brown CC, Swanson C, Brownson RC. Saturated fat intake and lung cancer risk among nonsmoking women in Missouri. J Natl Cancer Inst 1993; 85:1906–1916.CrossRefGoogle Scholar
  35. 33.
    Knekt P, Järvinen R, Seppänen R, Rissanen A, Aromaa A, Heinonen OP, Albanes D, Heinonen M, Pukkala E, Teppo L. Dietary antioxidants and the risk of lung cancer. Am J Epidemiol 1991; 134:471–479.Google Scholar
  36. 34.
    Freudenheim JL, Graham S. Toward a dietary prevention of cancer. Epidemiol Rev 1989; 11:229–235.Google Scholar
  37. 35.
    Kolonel LN. Lung cancer: another consequence of a high-fat diet? (editorial) J Natl Cancer Inst 1993; 85:1886,1887.Google Scholar
  38. 36.
    Cambien F, Ducimetiere P, Richard J. Total serum cholesterol and cancer mortality in a middle-aged male population. Am J Epidemiol 1980; 112:388–394.Google Scholar
  39. 37.
    Dyer AR, Stamler J, Paul O, Shekelle RB, Schoenberger JA, Berkson DM, Lepper M, Collette P, Shekelle S, Lindberg HA. Serum cholesterol and risk of death from cancer and other causes in three Chicago epidemiological studies. J Chron Dis 1981; 34:249–260.CrossRefGoogle Scholar
  40. 38.
    Kagan A, McGee DL, Yano K, Rhoads GG, Nomura A. Serum cholesterol and mortality in a JapaneseAmerican population. The Honolulu Heart Program. Am J Epidemiol 1981; 114:11–20.Google Scholar
  41. 39.
    Keys A, Aravanis C, Blackburn H, Buzina R, Dontas AS, Fidanza F, Karvonen MJ, Menotti A, Nedeljkovic S, Punsar S, Toshima H. Serum cholesterol and cancer mortality in the Seven Countries Study. Am J Epidemiol 1985; 121:870–883.Google Scholar
  42. 40.
    Menkes MS, Comstock GW, Vuilleumier JP, Helsing KJ, Rider AA, Brookmeyer R. Serum betacarotene, vitamins A and E, selenium, and the risk of lung cancer. New Engl J Med 1986; 315:1250–1254.CrossRefGoogle Scholar
  43. 41.
    Kok FJ, van Dujn CM, Hofman A, Vermeeren R, de Brujn AM, Valkenburg HA. Micronutrients and the risk of lung cancer (letter). New Engl J Med 1987; 316:1416.Google Scholar
  44. 42.
    Stähelin HB, Gey KF, Eichholzer M, Ludin E, Bernasconi F, Thurneysen J, Brubacher G. Plasma antioxidant vitamins and subsequent cancer mortality in the 12-year follow-up of the Prospective Basel Study. Am J Epidemiol 1991; 133:766–775.Google Scholar
  45. 43.
    Stähelin HB, Rösel F, Buess E, Brubacher G. Dietary risk factors for cancer in the Basel Study. Biblthca Nutr Dieta 1986; 37:144–153.Google Scholar
  46. 44.
    Koo LC. Dietary habits and lung cancer risk among Chinese females in Hong Kong who never smoked. Nutr Cancer 1988; 11:155–172.CrossRefGoogle Scholar
  47. 45.
    Wu-Williams AH, Dai XD, Blot W, Xu ZY, Sun XW, Xiao HP et al. Lung cancer among women in northeast China. Br J Cancer 1990; 62:982–987.CrossRefGoogle Scholar
  48. 46.
    Bandera EV, Freudenheim JL, Graham S, Marshall JR, et al. Alcohol consumption and lung cancer in white males. Cancer Causes Control 1992; 3:361–369.CrossRefGoogle Scholar
  49. 47.
    Chow WH, Schuman LM, McLaughlin JK, Bjelke E, Gridley G, Wacholder S, Chien HTC, Blot WJ. A cohort study of tobacco use, diet, occupation, and lung cancer mortality. Cancer Causes Control 1992; 3:247–254.CrossRefGoogle Scholar
  50. 48.
    Steinmetz KA, Potter JD, Folsom AR. Vegetables, fruit, and lung cancer in the Iowa Women’s Health Study. Cancer Res 1993; 53:536–543.Google Scholar
  51. 49.
    Shibata A, Paganini-Hill A, Ross RK, Henderson BE. Intake of vegetables, fruits, beta-carotene, vitamin C and vitamin supplements and cancer incidence among the elderly: a prospective study. Br J Cancer 1992: 66:673–679.CrossRefGoogle Scholar
  52. 50.
    Kalandidi A, Katsouyanni K, Voropoulou N, Bastas G, Saracci R, Trichopoulos D. Passive smoking and diet in the etiology of lung cancer among non-smokers. Cancer Causes Control 1990; 1:15–21.CrossRefGoogle Scholar
  53. 51.
    Harris R, Key T, Silcocks P, Bull D, Wald N. A case-control study of dietary carotene in men with lung cancer and in men with other epithelial cancers. Nutr Cancer 1991; 15:63–68.CrossRefGoogle Scholar
  54. 52.
    Forman MR, Yao SX, Graubard BI, Qiao YL, McAdams M, Mao BL, Taylor PR. The effect of dietary intake of fruits and vegetables on the odds ratio of lung cancer among Yunnan tin miners. Int J Epidemiol 1992; 21:437–441.CrossRefGoogle Scholar
  55. 53.
    Candelora E, Stockwell H, Armstrong A, Pinkharn P. Dietary intake and risk of lung cancer in women who never smoked. Nutr Cancer 1992; 17:263–270.CrossRefGoogle Scholar
  56. 54.
    Swanson CA, Mao BL, Li JY, Lubin JH, Yao SX, Wang JZ, Cai SK, Hou Y, Luo QS, Blot WJ. Dietary determinants of lung-cancer risk: Results from a case-control study in Yunnan Province, China. Int J Cancer 1992• 500•R76–8800Google Scholar
  57. 55.
    Dorgan JF, Ziegler RG, Schoenberg JB, Hartge P, McAdams MJ, Falk RT, Wilcox HB, Shaw GL. Race and sex differences in associations of vegetables, fruits, and carotenoids with lung cancer risk in New Jersey (United States). Cancer Causes Control 1993; 4:273–281.Google Scholar
  58. 56.
    Gao C, Taioma K, Kuroishii T, Hirose K, Inoue M. Protective effects of raw vegetables and fruit against lung cancer among smokers and ex-smokers: a case-control study in the Tokai area of Japan. Jpn J Cancer Res 1993; 84:594–600.CrossRefGoogle Scholar
  59. 57.
    Mayne ST, Janerich DT, Greenwald P, Chorost S, Tucci C, Zaman MB, Melamed MR, Kiely M, McKneally MF. Dietary beta carotene and lung cancer risk in U. S. nonsmokers. J Nail Cancer Inst 1994; 86:33–38.CrossRefGoogle Scholar
  60. 58.
    Sankaranarayanan R, Varghese C, Duffy SW, Padmakumary G, Day NE, Nair MK. A case-control study of diet and lung cancer in Kerala, South India. Int J Cancer 1994; 58:644–649.CrossRefGoogle Scholar
  61. 59.
    Butrum RR, Clifford CK, Lanza E. NCI dietary guidelines: rationale. Am J Clin Nutr 1988; 48:888–895.Google Scholar
  62. 60.
    Willett WC. Diet and health: What should we eat? Science 1994; 264:532–537.CrossRefGoogle Scholar
  63. 61.
    Bjelke E. Dietary vitamin A and human lung cancer. Int J Cancer 1975; 15:561–565.CrossRefGoogle Scholar
  64. 62.
    Pastorino U, Pisani P, Berrino F, Andreoli C, Barbieri A, Costa A, Mazzoleni C, Gramegna G, Marubini, E. Vitamin A and female lung cancer: a case-control study on plasma and diet. Nutr Cancer 1987; 10:171–179.CrossRefGoogle Scholar
  65. 63.
    LeMarchand L, Yoshizawa CN, Kolonel LN, Hankin JH, Goodman MT. Vegetable consumption and lung cancer risk: a population-based case-control study in Hawaii. J Natl Cancer Inst 1989; 81:1158–1164.CrossRefGoogle Scholar
  66. 64.
    Dartigues J-F, Dabis F, Gros N, Moise A, Bois G, Salamon R, Dilhuydy J-M, Courty G. Dietary vitamin A, beta carotene and risk of epidermoid lung cancer in south-western France. Europ J Epidemiol 1990; 6:261–265.CrossRefGoogle Scholar
  67. 65.
    Comstock GW, Alberg AJ, Helzlsouer KJ. Reported effects of long-term freezer storage on concentrations of retinol, B-carotene, and a-tocopherol in serum or plasma summarized. Clin Chem 1993; 39: 1075–1078.Google Scholar
  68. 66.
    Willett WC, Polk BF, Underwood BA, Stampfer MJ, Pressel S, Rosner B, Taylor JO, Schneider K, Hames CG. Relation of serum vitamins A and E and carotenoids to the risk of cancer. New Engl J Med 1984; 310:430–434.CrossRefGoogle Scholar
  69. 67.
    Nomura AMY, Stemmermann GN, Heilbrun LK, Salkeld RM, Vuilleumier JP. Serum vitamin levels and the risk of cancer of specific sites in men of Japanese ancestry in Hawaii. Cancer Res 1985; 45:2369–2372.Google Scholar
  70. 68.
    Wald N, Boreham J, Bailey A. Serum retinol and subsequent risk of cancer. Br J Cancer 1986; 54:957–961.CrossRefGoogle Scholar
  71. 69.
    Friedman GD, Blaner WS, Goodman DS, Vogelman JH, Brind JL, Hoover R, Fireman BH, Orentreich N. Serum retinol and retinol-binding protein levels do not predict subsequent lung cancer. Am J Epidemiol 1986: 123:781–789.Google Scholar
  72. 70.
    Connett JE, Kuller LH, Kjelsberg MO, Polk BF, Collins G, Rider A, Hulley SB. Relationship between carotenoids and cancer. The Multiple Risk Factor Intervention Trial (MRFIT) Study. Cancer 1989; 64:126–134.CrossRefGoogle Scholar
  73. 71.
    Knekt P, Aromaa A, Maatela J, Aaran R-K, Nikkari T, Hakama M, Hakulinen T, Peto R, Teppo L. Serum vitamin A and subsequent risk of cancer: cancer incidence follow-up of the Finnish Mobile Clinic Health Examination Survey. Am J Epidemiol 1990; 132:857–870.Google Scholar
  74. 72a.
    Knekt P. Vitamin E and smoking and the risk of lung cancer. Ann NYAcad Sci 1993; 686;280–287.CrossRefGoogle Scholar
  75. 72b.
    Omenn GS, Goodman GE, Thornquist MO, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL Jr, Valanis B, Willians JH Jr, Barnhart S, Hammar S. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. New Engl J Med 1996; 334:1150–1155.CrossRefGoogle Scholar
  76. 73.
    Peto R, Doll R, Buckley JD, Sporn MB. Can dietary beta-carotene materially reduce human cancer rates? Nature 1981; 290:201–208.CrossRefGoogle Scholar
  77. 74.
    Doll R, Peto R. The Causes of Cancer. Oxford: Oxford University Press, 1981; 1–1312.Google Scholar
  78. 75.
    Bieri JG, Brown ED, Smith Jr JC. Determination of individual carotenoids in human plasma by high performance liquid chromatography. J Liquid Chromatogr 1985; 8:473–484.CrossRefGoogle Scholar
  79. 76.
    LeMarchand L, Hankin JH, Kolonel LN, Beecher GR, Wilkens LR, Zhao LP. Intake of specific carotenoids and lung cancer risk. Cancer Epidemiol Biomarkers Prev 1993; 2:183–187.Google Scholar
  80. 77.
    Kronhout D. Essential micronutrients in relation to carcinogenesis. Am J Clin Nutr 1987; 45: 1361–1367.Google Scholar
  81. 78.
    Shekelle RB, Tangney CC, Rossof AH, Stamler J. Serum cholesterol, beta-carotene, and risk of lung cancer. Epidemiol 1992: 3:282–287.CrossRefGoogle Scholar
  82. 79.
    Wald NJ, Thompson SG, Densem JW, Boreham J, Bailey A. Serum beta-carotene and subsequent risk of cancer: results from the BUPA study. Br J Cancer 1988; 57:428–433.CrossRefGoogle Scholar
  83. 80.
    Orentreich N, Matias JR, Vogelman JH, Salkeld RM, Bhagavan H, Friedman GD. The predictive value of serum B-carotene for subsequent development of lung cancer. Nutr Cancer 1991; 16:167–169.CrossRefGoogle Scholar
  84. 81.
    The Alpha-Tocopherol Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. New Engl J Med 1994; 330:1029–1035.Google Scholar
  85. 82a.
    Hennekens CH, Buring JE, Manson JE, Stampfer M, Rosner B, Cook NR, Belanger C, LaMotte F, Gaziano JM, Ridker PM, Willett W, Peto R. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. New Engl J Med 1996; 334:1145–1149.CrossRefGoogle Scholar
  86. 82b.
    Blumberg J, Block G. The Alpha-tocopherol, Beta-carotene Cancer Prevention Study in Finland. Nutr Rev 1994; 52:242–245.CrossRefGoogle Scholar
  87. 83.
    Gaziano JM, Johnson EJ, Russell RM, Manson JE, Stampfer MJ, Ridker PM, Frei B, Hennekens CH, Krinsky NI. Discrimination in absorption or transport of β-carotene isomers after oral supplementation with either all-trans- or 9-cis-β-carotene. Am J Clin Nutr 1995: 61:1248–1252.Google Scholar
  88. 84.
    Kostic D, White WS, Olson JA. Intestinal absorption, serum clearance, and interactions between lutein and β-carotene when administered to human adults in separate or combined oral doses. Am J Clin Nutr 1995; 62:604–610.Google Scholar
  89. 85.
    Wahlquist ML, Wattanapenpaiboon N, Macrae FA, Lambert JR, MacLennan R, Hsu-Hage B H-H, Australian Polyp Prevention Project Investigators. Changes in serum carotenoids in subjects with colorectal adenomas after 24 months of β-carotene supplementation. Am J Clin Nutr 1994; 60:936–943.Google Scholar
  90. 86.
    Knekt P. Serum alpha-tocopherol and the risk of cancer. Publications of the Social Insurance Institution, Finland, ML:83. Helsinki, Social Insurance Institution; 1988.Google Scholar
  91. 87.
    Cameron E, Pauling L. Ascorbic acid and the glycosaminoglycans: an orthomolecular approach to cancer and other diseases. Oncology 1973; 27:181–192.CrossRefGoogle Scholar
  92. 88.
    Kvale G, Bjelke E, Gart JJ. Dietary habits and lung cancer risk. Int J Cancer 1983; 31:397–405.CrossRefGoogle Scholar
  93. 89.
    Hinds MW, Kolonel LN, Hankin JH, Lee J. Dietary vitamin A, carotene, vitamin C and risk of lung cancer in Hawaii. Am J Epidemiol 1984; 119:227–237.Google Scholar
  94. 90.
    Enstrom JE, Kanim LE, Klein MA. Vitamin C intake and mortality among a sample of the United States population. Epidemiol 1992; 3:194–202.CrossRefGoogle Scholar
  95. 91.
    Heimburger DC, Alexander CB, Birch R, Butterworth Jr CE, Bailey WC, Krumdieck CL. Improvement in bronchial squamous metaplasia in smokers treated with folate and vitamin B12. JAMA 1988; 259• 1525–1530Google Scholar
  96. 92.
    Subcommittee on Nutrition, Committee on Animal Nutrition, Board on Agriculture, National Research Council. Selenium in Nutrition, Revised Edition. Washington: National Academy Press, 1983; 1.Google Scholar
  97. 93.
    Willett WC, Polk BF, Morris JS, Stampfer MJ, Pressel S, Rosner B, Taylor JO, Schneider K, Hames CG. Prediagnostic serum selenium and risk of cancer. Lancet 1983; 2:130–134.CrossRefGoogle Scholar
  98. 94.
    Salonen JT, Alfthan G, Huttunen JK, Puska P. Association between serum selenium and the risk of cancer. Am J Epidemiol 1984; 120:342–349.Google Scholar
  99. 95.
    Nomura AMY, Heilbrun LK, Morris JS, Stemmermann GN. Serum selenium and the risk of cancer, by specific sites: a case-control analysis of prospective data. J Natl Cancer Inst 1987: 79:103–108.Google Scholar
  100. 96.
    Coates RJ, Weiss NS, Daling JR, Morris JS, Labbe RF Serum levels of selenium and retinol and the subsequent risk of cancer. Am J Epidemiol 1988; 128:515–523.Google Scholar
  101. 97.
    Ringstad J, Jacobsen BK, Tretli S, Thomassen Y. Serum selenium concentration associated with risk of cancer. J Clin Path 1988; 41:454–457.CrossRefGoogle Scholar
  102. 98.
    Knekt P, Aromaa A, Maatela J, Alfthan G, Aaran R-K, Hakama M, Hakulinen T, Peto R, Teppo L. Serum selenium and subsequent risk of cancer among Finnish men and women. J Natl Cancer Inst 1990; 82:864–868.CrossRefGoogle Scholar
  103. 99.
    Criqui MH, Bangdiwala S, Goodman DS, Blaner WS, Morris JS, Kritchevsky S, Lippel K, Mebane I, Tyroler HA. Selenium, retinol, retinol-binding protein, and uric acid associations with cancer mortality in a population-based prospective case-control study. Ann Epidemiol 1991; 1:385–393.CrossRefGoogle Scholar
  104. 100.
    van den Brandt PA, Goldbohm RA, van’t Veer P, Bode P, Dorant E, Hermus RJJ, Sturmans F. A prospective cohort study on selenium status and the risk of lung cancer. Cancer Res 1993; 53:4860–4865.Google Scholar
  105. 101.
    Kabuto M, Imai H, Yonezawa C, Neriishi K, Akiba S, Kato H, Suzuki T, Land CE, Blot WJ. Prediagnostic serum selenium and zinc levels and subsequent risk of lung and stomach cancer in Japan. Cancer Epidemiol Biomarkers Prev 1994; 3:465–469.Google Scholar
  106. 102.
    Garland M, Morris JS, Stampfer MJ, Colditz GA, Spate VL, Baskett CK, Rosner B, Speizer FE, Willett WC, Hunter DJ. Prospective study of toenail selenium levels and cancer among women. J Natl Cancer Inst 1995; 87:497–505.CrossRefGoogle Scholar

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© Springer Science+Business Media New York 1997

Authors and Affiliations

  • George W. Comstock
  • Kathy J. Helzlsouer

There are no affiliations available

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