Neuroimaging in human aggression

Conceptual and methodological issues
  • Michael Wong


The association between brain structure and function and human aggression and violence is a controversial and difficult subject. Apart from some case reports1–4, major application of neuroimaging techniques such as positron emission tomography (PET) and magnetic resonance imaging (MRI) in this field are few.5–7 This article reviews the relevant conceptual and methodological issues and suggests future directions.


Positron Emission Tomogra Personality Disorder Attention Deficit Hyperactivity Disorder Temporal Lobe Epilepsy Violent Behaviour 
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  1. 1.
    Volkow, N.D. and Tancredi, L., 1987, Neural substrates of violent behaviour–A preliminary study of positron emission tomography. British Journal of Psychiatry, 151: 668–673.PubMedCrossRefGoogle Scholar
  2. 2.
    Tonkonogy, J.M., 1991, Violence and temporal lobe lesion: Head CT and MRl data. Journal ofNeuropsychiatry and Clinical Neurosciences, 3: 189–196.Google Scholar
  3. 3.
    Seidenwurm, D., Pounds, T., Globus, A., Valk, P., 1994, Temporal lobe metabolism in violent behaviour: correlation of FDG-PET, EEG, MRl and neuropsychiatrie findings. Abstract of the Ninety-Fourth Annual Meeting of the American Roentgen Ray Society, New Orleans, LA, April 24–29.Google Scholar
  4. 4.
    Goyer, P.F., Andreason, P. J., Semple, W.E., Clayton, A.H., King, A.C., Compton-Toth, B.A., Schultz, S.C. and Cohen, R.M., 1994, Positron-Emission Tomography and Personality Disorders. Neuropsychopharmacology, 1021–28.Google Scholar
  5. 5.
    Raine, A., Buchsbaum, M.S., Stanley, J., Lottenberg, S., Abel, L., Stoddard, J., 1994, Selective Reductions in Prefrontal Glucose Metabolism in Murderers. Biological Psychiatry, 36: 365–373.PubMedCrossRefGoogle Scholar
  6. 6.
    Wong, M.T.H., Fenwick, P.B.C., Fenton, G.W., Lumsden, J., Maisey, M.M., Stevens, J., 1997, Repetitive and non-repetitive violent offending behaviour in male patients in a maximum security mental hospital. Medicine, Science and the Law, 37: 150–160.Google Scholar
  7. 7.
    Wong, M.T.H., Fenwick, P.B.C., Lumsden, J., Fenton, G.W., Maisey, M.N., Lewis, P., Badawi, R, 1997, Positron Emission Tomography in male violent offenders with schizophrenia. Psychiatry Research: Neuroimaging, 68: 111–123.PubMedCrossRefGoogle Scholar
  8. 8.
    Hinde, R. A., 1970, Animal Behaviour: a synthesis of Ethology and comparative Psychology, 2nd Edition. Tokyo: McGraw-Hill Kogakusha.Google Scholar
  9. 9.
    Bandura, A., 1973, Aggression: A Social Learning Analysis. Englewood Sliffs, NJ: Prentice-Hall.Google Scholar
  10. 10.
    Volavka, J., 1995, Neurobiology of Violence. Washington DC: American Psychiatric Press.Google Scholar
  11. 11.
    Spellacy F., 1978, Neuropsychological Discrimination Between Violent and Nonviolent Men. Journal of Clinical Psychology, 34, 49–52.PubMedCrossRefGoogle Scholar
  12. 12.
    Elliot, F.A., 1982, Neurological findings in adult minimal brain dysfunction and the dyscontrol syndrome. Journal of Nervous and Mental Disease, 170, 680–687.CrossRefGoogle Scholar
  13. 13.
    Coccaro, E.F., 1989, Central Serotonin and Impulsive Aggression. British Journal of Psychiatry, 155 (Suppl. 88), 52–62.Google Scholar
  14. 14.
    Moyer, K.E.,1976, The Psychobiology of Aggression New York: Harper and Row.Google Scholar
  15. 15.
    Lorenz, K.Z., 1966, On aggression. New York: Harcourt, Brace and World.Google Scholar
  16. 16.
    Blackburn, R., 1968, Emotionality, extraversion, and aggression of paranoid and nonparanoid schizophrenic offenders. British Journal of Psychiatry, 115: 1301–1302CrossRefGoogle Scholar
  17. 17.
    Studer RL., Jackson, A.H., Harnratz, J.S., Appelbaum, P.S., 1977, Patterns of violent behaviour among schizophrenic inpatients. Disease of the Nervous System, 38: 13–16.Google Scholar
  18. 18.
    Addad, M., Benezech, M., Bourgeois, M., Yesage, J., 1981, Criminal acts among schizophrenics in French mental hospitals. Journal of Nervous and Mental Disease, 169: 289–293.PubMedCrossRefGoogle Scholar
  19. 19.
    Tardiff, K. and Sweillam, A., 1982, Assaultive behavior among chronic inpatients. American Journal of Psychiatry, 147: 491–498.Google Scholar
  20. 20.
    Aggleton, J.P., 1993, The contribution of the amygdala to normal and abnormal emotional states. Trends in Neurosciences, 16: 328–333.PubMedCrossRefGoogle Scholar
  21. 21.
    Adamec, RE.,1989, Role of the amygdala and medial hypothalamus in spontaneous feline aggression and defence. Aggressive Behaviour, 16, 207–222.Google Scholar
  22. 22.
    Pucilowski, O, Plaznik, A., Kostowski, W., 1985, Aggressive behaviour inhibition by serotonin and quipazine injected into the amygdala in the rat. Behaviour and Neural Biology, 43: 58–68.CrossRefGoogle Scholar
  23. 23.
    Eichelman, B., 1992, Aggressive Behaviour: From Laboratory to Clinic. Quo Vadit? Archives of General Psychiatry, 49, 488–492.PubMedCrossRefGoogle Scholar
  24. 24.
    Raine, A., Scerbo, A., 1991, Biological Theories of Violence. In Milner, J.S., eds., Neuropsychology of Aggression. Narwhal, MA: Kluwer Academic Publishers, 1–25.CrossRefGoogle Scholar
  25. 25.
    Fenwick, P., 1993, Brain, mind and behaviour: Some medico-legal aspects. British Journal of Psychiatry, 163: 565–573PubMedCrossRefGoogle Scholar
  26. 26.
    Yeudall, LT., 1978, The neuropsychology of aggression. Clarence Hinks Memorial Lecture, University of Western Ontario.Google Scholar
  27. 27.
    Weiger, B. and Bear, D., 1988, An approach to the neurology of aggression. Journal of Psychiatric Research, 22, 85–98.PubMedCrossRefGoogle Scholar
  28. 28.
    Hollin, C.R. and Howells, K., 1989, An Introduction to Concepts, Models and Techniques. In Howells, K. and Hollin, C.R. (eds.) Clinical Approaches to Violence. Chichester, John Wiley & Sons Ltd., 3–24.Google Scholar
  29. 29.
    Elliot, F.A., 1992, Violence–the neurological contribution: an overview. Archives of Neurology, 49, 595–603.CrossRefGoogle Scholar
  30. 30.
    Wong M.T.H., Lumsden, J., Fenton, GW, Fenwick, P.B.C., 1994, Epilepsy and violence in mentally abnormal offenders in a maximum security mental hospital. Journal of Epilepsy, 7, 253–258.CrossRefGoogle Scholar
  31. 31.
    Klingman, D., Goldberg, D.T., 1975, Temporal lobe epilepsy and aggression. Journal of Nervous and Mental Disease, 160, 324–341.CrossRefGoogle Scholar
  32. 32.
    Stevens, J.R, Herman, B., 1981, Temporal lobe epilepsy, psychopathology and violence: the state of evidence. Neurology, 31, 1127–1132.PubMedCrossRefGoogle Scholar
  33. 33.
    Robins, L.N., 1978, Sturdy childhood predictors of adult antisocial behaviour: replications from longitudinal studies. Psychological Medicine, 611–622.Google Scholar
  34. 34.
    Stattin, H., Magnusson, D., 1989, The role of early aggressive behavior in the frequency, seriousness, and types of later crime. Journal of Consulting and Clinical Psychology, 57, 710–718.PubMedCrossRefGoogle Scholar
  35. 35.
    Huesmann, L.R., Eron, L.D., Lelkowit, M.M. et al, 1984, Stability of aggression over time of generations. Developmental Psychology, 20, 1120–1134.CrossRefGoogle Scholar
  36. 36.
    Patterson, G.R, Reid, J.B., Dishion, T.J., 1992, Antisocial Boys: A Social Interactional Approach, Vol. 4. Eugene, OR: Castalia.Google Scholar
  37. 37.
    Dell, S. and Robertson G., 1988, Sentenced to Hospital: Offenders in Broadmoor. Oxford: Oxford University Press.Google Scholar
  38. 38.
    Wong, M., Lumsden, J., Fenton, G., Fenwick, P., 1993, Violence ratings of special hospital patients. Journal of Forensic Psychiatry, 4, 471–480.CrossRefGoogle Scholar
  39. 39.
    Buss, A.R. Durkee, A., 1957, An inventory for assessing different kinds of hostility. Journal of Consulting Psychology, 21, 343–349.CrossRefGoogle Scholar
  40. 40.
    Brown, G.L., Goodwin, F.K., Ballenger, J.C., Goyer, P.F., Major, L.F., 1979, Aggression in Humans correlates with cerebrospinal fluid amine metabolites. Psychiatry Research, I, 131–139.Google Scholar
  41. 41.
    Yudofsky, S. C., Silver, J. M., Jackson, W., Endicott, J. and Williams, D.. 1986. The overt aggression scale for the objective rating of verbal and physical aggression. American Journal of Psychiatry, 143, 35–39.PubMedGoogle Scholar
  42. 42.
    Palmstierna, T., Wistedt, B., 1987, Staff observation aggression scale, SOAS: presentation and evaluation. Acta Psychiatrica Scandinavira, 76, 657–663.CrossRefGoogle Scholar
  43. 43.
    Knoedler, D.W., 1989, The Modified Overt Aggression Scale. American Journal of Psychiatry, 146, 1081–1082.PubMedGoogle Scholar
  44. 44.
    Wistedt, B., Rasmussen, A., Pedersen, L, Malm, U., Traskman-Bendz, L., Wakelin, J. and Bech, P., 1990, The development of an observer-scale for measuring social dysfunction and aggression. Pharmacopsychiatty, 23, 249–252.CrossRefGoogle Scholar
  45. 45.
    Robertson, G., Taylor, P. J. and Gunn, J., 1987, Does violence have cognitive correlates? British Journal of Psychiatry, 151, 63–68.PubMedCrossRefGoogle Scholar
  46. 46.
    Coccaro, E.F., Berman, M.E., Kavoussi, R.J., 1997, Assessment of life history of aggression: development and psychometric characteristics. Psychiatric Research, 73, 147157.Google Scholar
  47. 47.
    Hill, D., Pond, D., 1952, Reflections on a hundred capital cases submitted to EEG. Journal of Mental Science, 98, 23–43.PubMedGoogle Scholar
  48. 48.
    Sayed, Z.A., Lewis, S.A., Brittain, R.P., 1969, An electroencephalographic and psychiatric study of thirty-two insane murderers. British Journal of Psychiatry, 115, 11151124.Google Scholar
  49. 49.
    Okasha, A., Sadek, A.O., Monies, S.A., 1975, Psychosocial and electroencephalographic studies of Egyptian murderers. British Journal of Psychiatry, 126, 34–40.PubMedCrossRefGoogle Scholar
  50. Heath, ILG., Monroe, R.R., Mickle, W.A., 1955, Stimulation of the amygdaloid nucleus in a schizophrenic patient. American Journal of Psychiatry, I I I, 862–863.Google Scholar
  51. 51.
    Heath. R. G. and Mickle, W. A., 1960. Evaluation of seven years’ experience with depth electrode studies in human patients. In Ramey, E. R. and O’Doherty, D. S., eds., Electrical studies on unanesthetized brain. New York: Hoeber.Google Scholar
  52. 52.
    Delgado, J.M.R-, Mark, V., Sweet, S., Ervin, F., Weiss, G., Bach-Y-Rita, G. and Hagiwara, R., 1968, Intracerebral radio stimulation and recording in completely free patients. Journal of Nervous and Mental Disease, 147, 329–340.PubMedCrossRefGoogle Scholar
  53. 53.
    Hill, D., 1944, Cerebral dysrhythmia: its significance in aggressive behaviour. Proceedings of the Royal Society of Medicine, 37, 317–328.PubMedGoogle Scholar
  54. 54.
    Hill, D., 1952, EEG in episodic and psychopathic behaviour. Electroencephalography and Clinical Neurophysiology, 4, 419–442.PubMedCrossRefGoogle Scholar
  55. Fenton, G.W., Tennant, T.G., Fenwick, P.B.C. and Rattray, N., 1974, A study of posterior temporal slow activity in special hospital patients. Psychological Medicine, 4, 181–186.CrossRefGoogle Scholar
  56. 56.
    Driver, MV, West, L.R., Faulk, M., 1974, Clinical and EEG studies of prisoners charged with murder. British Journal of Psychiatry, 125, 583–587.PubMedCrossRefGoogle Scholar
  57. 57.
    Fishbein, D.H., Heming, R., Pickworth, W.B. et. al., 1989, EEG and brainstem auditory evoked response potentials in adult male drug abuses with self reported histories of aggressive behavior. Biological Psychiatry, 26, 595–611.PubMedCrossRefGoogle Scholar
  58. 58.
    Convit, A., Czobor, P., Volavka, J., 1991, Lateralised abnormality in the EEG of persistently violent psychiatric inpatients. Biological Psychiatry, 30, 363–370.PubMedCrossRefGoogle Scholar
  59. 59.
    Wong, M.T.H., Lumsden, J., Fenton, G.W., Fenwick, P.B.C., 1994, Electroencephalography, computed tomography and violence ratings of male patients in a maximum-security mental hospital. Acta Psychiatrica Scandinavica, 90, 97-IOI.Google Scholar
  60. 60.
    Wahlund, L.-O., Agartz, I., Saaf, J., Wetterberg, L., Marion, 0., 1992, MRI in Psychiatry: 731 Cases. Psychiatry Research: Neuroimaging, 45, 139–140.PubMedCrossRefGoogle Scholar
  61. 61.
    Brown, F.W., Lewine, R.J., Hudgins, P.A. and Risch, S.C., 1992, White matter hyperintensity signals in psychiatric and non-psychiatric subjects. American Journal of Psychiatry, 149, 620–625.PubMedGoogle Scholar
  62. 62.
    Wohl, M.A., Mehringer, C M, Lesser, I.M., Boone, K.B., Miller, B.L., 1994, White matter hyperintensities in healthy older adults–a longitudinal study. International Journal of Geriatric Psychiatry, 9, 273–277.CrossRefGoogle Scholar
  63. 63.
    Owens, D.G.C., Johnstone, E.C., Bydder, G.M., Kreel, L., 1980, Unsuspected organic disease in chronic schizophrenia demonstrated by computed tomography. Journal of Neurology, Neurosurgery and Psychiatry, 43, 1065–1069.CrossRefGoogle Scholar
  64. 64.
    Raymond, A.A., Fish, D.R., Sisodiya, S.M., Alsanjari, N., Stevens, J.M., Shorvon, S.D., 1995, Abnormalities of gyration, heteropias, tuberous sclerosis, focal cortical dysplasia, microdysgenesis, dysembryoplastic neuroepithelial tumour and dysgenesis of the archicortex in epilepsy–clinical, EEG and neuroimaging features in 100 adult patients. Brain, 118, 629–660.PubMedCrossRefGoogle Scholar
  65. 65.
    Lee, N., Radtke, R.A., Gray, L., Burger, P.C., Montine, T.J., DeLong, G.R. et. al., 1994, Neuronal migration disorders: positron emission tomography correlations. Annuals of Neurology, 35, 290–297.CrossRefGoogle Scholar
  66. Kikinis, R., Shenton, M.E., Gerig, G., Hokama, H., Haimson, J., O’Donnell, F., Wible, C.G., McCarley, R.W. and Jolesz, F.A. (1994) Temporal lobe sulco-gyral pattern anomalies in schizophrenia–a in vivo MR Three-dimensional surface rendering study. Neuroscience Letters, 182, 7–12.CrossRefGoogle Scholar
  67. Wong, M.T.H., Lumsden, J., Fenton, G.W., Fenwick, P.B.C. (1997) Neuroimaging in Mentally Abnormal Offenders. Issues in Criminological and Legal Psychology, 27, 49–58.Google Scholar
  68. 68.
    Copolov, D.L., Seal, M.L., Maruff, P., Ulusoy, R., Wong, M.T.H., Tochon-Danguy, H.J., Egan, G.F., 1999, Cortical activation associated with the experience of auditory hallucinations and perception of human speech in schizophrenia: a PET correlation study. Abstracts of Winter Schizophrenia Workshop, Davos.Google Scholar
  69. 69.
    Wong, M.T.H., Woods, S., Velakoulis, D., Pantelis, C., McGorry, P., 2000, Amygdala volume smaller on both first episode psychosis and chronic schizophrenia. Abstracts of 6`“ Australasian Schziophrenia Conference, Lorne.Google Scholar
  70. Rubia, K., Overmeyer, S., Taylor, E., Brammer, M., Williams, S.C., Simmons, A, Bullmore, E.T., 1999, Hyporfontality in attention deficit hyperactivity disorder during higher-order motor control: a study with functional MRI. American Journal of Psychiatry, 156: 891–896.Google Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Michael Wong
    • 1
    • 2
    • 3
  1. 1.Department of Psychological MedicineMonash University, Maroondah Hospital CampusAcademicAustralia
  2. 2.Clinical Research UnitRingwood EastAustralia
  3. 3.Mental Health Research Institute of VictoriaParkvilleAustralia

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