The genetics of aggression
From mice to humans
Chapter
Abstract
The genetic analyses of aggression in mammals begins with two articles published almost sixty years agog1, 2. In both the C57BL10, C3H and BALB/c inbred strains were used, and in both the strains differed in measures of aggression. This was the first evidence that genes had a role in individual differences in aggression of any mammal. Both groups believed that their findings were relevant to other animals, especially humans Later, Scott3 wrote in the book Aggression: “It is the purpose of this book to take the important results from current animal research and relate or contrast them with the facts of human behavior.”
Keywords
Inbred Strain Antisocial Personality Disorder Congenic Strain Attack Behavior Pseudoautosomal Region
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References
- 1.Ginsburg, B. G. and Allee, W. C., 1942, Some effects of conditioning on social dominance and subordination in inbred strains of mice. Physiot Zool. 15: 485–506.Google Scholar
- 2.Scott, J. P., 1942, Genetic differences in the social behavior on inbred strains of mice. J Hered 33: 11–15.Google Scholar
- 3.Scott, J. P., 1958, Aggression. University of Chicago Press. Chicago.Google Scholar
- 4.Sandnabba, N. K, 1996, Selective breeding for isolation-induced aggression in mice: Associated responses and environmental influences. Behay. Genet. 26: 477–488.CrossRefGoogle Scholar
- 5.Gariepy, J.-L., Lewis, M. H., and Cairns, R. H., 1996, Genes, neurobiology and aggression: Time frames and functions of social behaviors in adaptation. In Aggression and Violence: Genetic, Neurobiological and Biosocial Perspectives (D. M. Stoff and R. B. Cairns, eds.), Lawrence Erlbaum Associates. Manwah, N. J., pp. 41–63.Google Scholar
- 6.Sluyter, F., Van Oortmerssen, G. A., Ruiter, A. J. H., and Koolhaas, J. M.,1996, Aggression in wild house mice: Current state of affairs. Behay. Genet. 26: 489–495.Google Scholar
- 7.Maxson, S.C., 1998, Homologous genes, aggression and animal models. bevel. Neuropsychol. 14: 143–156.Google Scholar
- 8.Maxson, S. C., 1999, Genetic influences on aggressive behavior. In Genetic Influences on neural and behavioral functions ( D. Pfaff, W. Berrettini, T. Joh, and S. Maxson eds.), CRC Press, Boca Raton, pp. 405–416.Google Scholar
- 9.Miczek, K. A., Masson, S. C., Fish, E. W. and Faccidomo, S., submitted, Aggressive behavioral phenotypes in mice. Behavioral Brain Research Google Scholar
- 10.Alleva, E., Cirulli, F., Bianchi, M., Bondiolotti, G. P., Chiarotti, F., DeAcetis, L. and Panerai, A., 1995, Behavioral characterization of interlukin-6 overexpression or deficit mice during agonsitic encounters. Eur. J. Neurosci. 10: 3664–3672.CrossRefGoogle Scholar
- 11.Maxson, S. C., Ginsburg, B. and Trattner A., 1979, Interaction of Y-chromosomal gene (s) in the development of intermale aggression in mice. Behay. Genet. 9: 219–226.CrossRefGoogle Scholar
- 12.Stewart, A. D., Manning, A., Batty J., 1980, Effects on Y chromosome variants on the male behaviour of the mouse Mus musculus. Genet. Res. (Cambr.) 35: 261–268.CrossRefGoogle Scholar
- 13.Carlier, M., Roubertoux, P. L. and Pastoret, C., 1991, The Y chromosome effect on intermale aggression in mice depends on the maternal environment. Genet. 129: 23l - 236.Google Scholar
- 14.Van Oortmerssen, G.A., 1984, A behavioral-genetic approach to variation in attack latency, serum testosterone level, and other agonistic parameters. Aggress. Behay. 10: 177–178.Google Scholar
- 15.Van Oortmerssen, G. A., and Sluyter, F., 1994, Studies in wild house mice: V. Aggression in selection lines for attack latency and their congenics for the Y chromosome. Behay. Genet. 24, 73–78.CrossRefGoogle Scholar
- 16.Carlier, M., Roubertoux, P. L., Kottler, M. L. and Degrelle, H., 1990, Y chormosome and aggression in strains of laboratory mice. Behay. Genet. 20: 137–156.Google Scholar
- 17.Simmler M. C., Rouyer, F., Vergnaud, G., Nystrom-Lahti, M., K. Ngo, K. Y.,De la Chapelle, A. and Weissenbach, J., 1985, Pseudoautosomal DNA sequences in the pairing region of the human sex chromosomes. Nature 317: 692–697.Google Scholar
- 18.Ellis, E. and Goodfellow, P. N., 1989, The mammalian pseudoautosomal region. T Genet. 5: 406–410.CrossRefGoogle Scholar
- 19.Selmanof£ M. K., Maxson, S. C. and Ginsburg, B., 1976, Chromosomal determinants of intermale aggressive behavior in inbred mice. Behay. Genet. 6: 53–69.CrossRefGoogle Scholar
- 20.Cartier, M. and Roubertoux, P. L., 1986, Differences between CBA/H and NZB mice on intermale aggression. I. Comparison between parental strains and reciprocal Fls, In Genetic Approaches to Behavioral Phenotypes ( J. Medioni and G. Vaysse, eds.) Privat, Toulouse. pp. 47–57.Google Scholar
- 21.Roubertoux, P. L. and Carlier, M., 1988, Differences between CBA/H and NZB on intermale aggression II–Maternal effects, Behay. Genet. 18: 175–184.CrossRefGoogle Scholar
- 22.Selmanoff, M. K., Jummonville, J. E., Maxson, S. C., and Ginsburg, B. E., 1975, Evidence for a Y chromosome contribution to an aggressive phenotype in mice. Nature 253: 529–530.PubMedCrossRefGoogle Scholar
- 23.Bailey, D. W., 1985, Genes that effect the shape of the murine mandible. Congenic strain analysis. J Hered. 76: 107–114.PubMedGoogle Scholar
- 24.Moutier, R. and Carlier M.,1991, Mandible shape analysis in Y-congenic strains of mice. Lab. Anim. 25: 303–307.Google Scholar
- 25.Roubertoux, P. L, Carlier, M., Degrelle, H., Haas-Dupertuis, M. C., Phillips, J., and Moutier, R., 1994, Co-segregation of the pseudoautosomal region of the Y chromosome with aggression in mice. Genet. 135: 254–263.Google Scholar
- 26.Guillot P., Carlier M. and Roubertoux P.L., 1995, The Y chromosome effect on intermale aggression in mice depends on the test situation and on the recorded variables. Behay. Genet. 25: 51–59.Google Scholar
- 27.Roubertoux, P.L., Le Roy I., Tordjman S., Mortaud S. and Carlier, M.,1999, Measuring aggression in the Mouse. In Molecular genetic Techniques for Behavioral Neuroscienc,. (W. E. Crusio and R Gerlai, eds.), Elsevier, Amsterdam, pp. 696–709Google Scholar
- 28.Roubertoux, P. I.., Degrelle, H., Maxson, S. C., Phillips, J., Tordjman, S., and DupertuisHaas, M. -C., 1994, Polymorphism for the alleles of the microsomal steroid sulfatase gene (Sts) in the pseudoautosomal region of the heterosomes of laboratory mice. C. lt Acad. Sci. Paris, 317: 523–527.Google Scholar
- 29.Mortaud, S., Donnes-Dared, E., Roubertoux, P. L., and Degrelle, H., 1995, Murine steroid sulfatase (mSTS): purification, characterization and measurement by ELISA. J. Ster. Biochem. Mol. Biol. 52: 91–96.CrossRefGoogle Scholar
- 30.Le Roy, I., Mortaud, S., Tordjman, S., Donsez-Darcel, E., Carlier, M., Degrelle, H., Roubertoux, P.L.,1999, Genetic correlation between expression of the steroid sulfatase gene, mapped on the pairing region of the Y-chromosome, and initiation of attack behavior in mice. Behay. Genet. 29, 131–136.Google Scholar
- 31.Maxson, S. C., 1996, Searching for candidate genes with effects on an agonistic behavior, offense, in mice Behay. Genet. 26, 471–476.CrossRefGoogle Scholar
- 32.Roubertoux, P.L., Mortaud, S., Tordjman, S., Le Roy,I. and Degrelle, H., 1998, Behavior-genetic analysis and aggression: the mouse as a prototype In Advances in Psychological Science: Biological and Cognitive Aspects. (M. Sabourin, F. Craik. and M. Robert eds,), Psychology Press, London, pp. 3–29.Google Scholar
- 33.Saudou, F., Amara, D. A., Dierich, A., Lemeur, M., Ramboz, S., Segu, L., Buhot, M.-C., and Hen, R., 1994, Enhanced aggressive behavior in mice lacking 5-HT I B receptor, Science, 265, 1875–1878.PubMedCrossRefGoogle Scholar
- 34.König, M., Zimmer, A. M.,Steiner, H., Holmes, P., Crawley, J., Brownstein, M. J., and Zimmer, A., 1996,. Pain response and aggression in mice deficient in pre-proenkephalin. Nature 383: 535–538.Google Scholar
- 35.Chen, C., Rainnie, D. G., Greene, R W., and Tonegawa S., 1994, Abnormal fear responses and aggressive behavior in mutant mice deficient for a-calcium-calmodulin kinase-II. Science 266: 291–294.PubMedCrossRefGoogle Scholar
- 36.Mathis, C., Paul, S. M., and Crawley, J. N., 1994, The neurosteroid pregnenolone sulfate blocks NMDA antagonist-induced deficits in a passive avoidance memory task. Psychopharm. 116: 201–206.CrossRefGoogle Scholar
- 37.Cloninger, CR, 1987, Neurogenetic adaptive mechanisms in alcoholism Science, 236, 410–416PubMedCrossRefGoogle Scholar
- 38.Kitties, R A, Long, J. C., Bergen, A. W., Eggert, M., Virkkunen, M., Linnoila, M., and Goldman, D., 1999, Cladistic association analysis of Y chromosome effectson alcohol dependence and related personality traits. Proc. Natl. Acad Sci. USA. 96: 4204–4209.CrossRefGoogle Scholar
- 39.Lappalainen, J., Long, J.C., Eggert, M., Ozaki, N., Robin, R.W., Brown, G.L., Naukkarinen, H., Virkkunen, M., Linnoila, M., and Goldman, D., 1998, Linkage of antisocial alcoholism to the serotonin 5-HT! B receptor gene in 2 populations. Arch Gen. Psychiatry 55: 989–94.PubMedCrossRefGoogle Scholar
- 40.Brunner, D, and Hen, R., 1997, Insights into the neurobiology of impulsive behavior from serotonin receptor knockout mice. Ann. N YAcad Sci. 836: 81–105.CrossRefGoogle Scholar
- 41.Enoch, M. A. and Goldman, D., 1999, Genetics of alcoholism. In: Genetic Influences on neural and behavioral functions ( D. Pfaff, W. Berrettini, T. Joh, and S. Masson, eds.), CRC Press, Boca Raton, pp. 147–157.Google Scholar
- 42.Brunner, H. G., 1996, MAOA deficiency and abnormal behaviour: perspectives on an association. In: Genetics of Criminal and Antisocial Behaviour (G. R. Brock and J. A. Goode, eds.), Wiley, New York, pp. 155–64; discussion pp. 164–167.Google Scholar
- 43.Hauser P., McMillin, J. M. and Bhatara, V. S., 1996, Resistance to thyroid hormone: implications for neurodevelopmental research on the effects of thyroid hormone disruptors. Taxied! Ind Health 14: 85–101.Google Scholar
- 44.Blanchard, D. C., Hebert, M., and Blanchard, R. J., 1999, Continuity versus (political) correctness: animal models and human aggression. In Animal Models of Human Emotion and Cognition ( M. Haug and R. E. Whalen, eds.) American Psychological Association, Washington, DC, pp. 297–316.CrossRefGoogle Scholar
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