Biochemical and molecular genetic factors in habitual violence and antisocial alcoholism

Control and preventive interventions
  • Matti Virkkunen
Chapter

Abstract

Serotonin has been found to play a central role in impulsive and habitual violent tendencies and personality disorders, and there is much evidence supporting the inverse relationship between impulsivity/aggression and central serotonergic activity. Biological factors, such as low brain serotonin turnover together with glucose metabolism and low brain noradrenaline turnover have been predictive of further violence among prisoners who evidence Antisocial Personality Disorder (ASP)1,2. However, according to recent reviews, the role of noradrenaline in impulsive aggression is still unclear3. Some studies demonstrate that increa sing noradrenaline correlates to impulsive aggression, whereas other studies demonstrate an opposite relationship. The role of dopamine and gamma-aminobutyric acid in human studies of these aggressive behaviors is still unclear and requires further investigation.

Keywords

Personality Disorder Maternal Smoking Borderline Personality Disorder Acute Tryptophan Depletion Violent Offender 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Matti Virkkunen
    • 1
  1. 1.Department of PsychiatryHelsinki University Central HospitalHelsinkiFinland

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