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Benign Lesions of the Cervix

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Pathology of the Female Genital Tract

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Abstract

Acute inflammation of the cervix results from direct infection by nonspecific microorganisms or by secondary invaders. The former group includes streptococci, staphylococci, and enterococci, and infections with these organisms are prone to occur in puerperal infections. Among the most common secondary invaders are the gram-negative diplococci, Neisseria gonorrhoea, Trichomonas vaginalis, and Candida albicans. Foreign bodies introduced into the vagina, namely, fragments of residual tampons and pes-series, may also lead to acute cervical inflammation. Clinically, acute cervicitis is manifested by purulent vaginal discharge, which is yellowish green when the infection is caused by Trichomonas and whitish with white flakes when Candida is the causative agent. Backache, vulvar pruritus, and painful urination, when the urethra is involved, are often accompanied by vaginal discharge. An acutely inflamed cervix is swollen and reddened because of an increase in stromal edema and terminal vasculature of the cervix. Histologically, there is extensive stromal edema with polymorphonuclear leukocytic infiltration and often focal loss of mucous membrane.

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References

  1. Aaro, L. A., Jacobson, L. J., and Soule, E. H. Endocervical polyps. Obstet. Gynecol. 21: 659, 1963.

    CAS  Google Scholar 

  2. Abell, M. R. Cervicocolpitis (vaginitis) emphysematosa. Surg. Gynecol. Obstet. 107: 631, 1958.

    PubMed  CAS  Google Scholar 

  3. Abell, M. R. Papillary adenofibroma of the uterine cervix. Am. J. Obstet. Gynecol. 110: 990, 1971.

    CAS  Google Scholar 

  4. Abell, M. R., and Gosling, J. R. G. Gland cell carcinoma (adenocarcinoma) of the uterine cervix. Am. J. Obstet. Gynecol. 83: 729, 1962.

    PubMed  CAS  Google Scholar 

  5. Adam, E., Kaufman, R. H., Melnick, J. L., Levy, A. H., and Rawls, W. E. Seroepidemiologic studies of herpesvirus type 2 and carcinoma of the cervix. III. Houston, Texas, Am. J. Epidemiol., 96: 427, 1972.

    PubMed  CAS  Google Scholar 

  6. Adam, E., Kaufman, R. H., Melnick, J. L., Levy, A. H., and Rawls, W. E. Seroepidemiologic studies of herpesvirus type 2 and carcinoma of the cervix. IV. Dysplasia and carcinoma in situ. Am. J. Epidemiol., 98: 77, 1973.

    PubMed  CAS  Google Scholar 

  7. Adams, J. Q., and Packer, H. Granuloma inguinale of the cervix. South. Med. J. 48: 27, 1955.

    CAS  Google Scholar 

  8. Beacham, W. D., and Rice, M. Diphteria of the uterine cervix. Am. J. Obstet. Gynecol. 47: 417, 1944.

    Google Scholar 

  9. Berry, A. A cytopathological and histopathological study of bilharziasis of the female genital tract. J. Pathol. Bacteriol. 91: 325, 1966.

    Article  CAS  Google Scholar 

  10. Burd, L. I., and Esterly, J. R. Vesicular lesions of the uterine cervix. Am. J. Obstet. Gynecol. 110: 887, 1971.

    CAS  Google Scholar 

  11. Busby, J. G. Neurofibromatosis of the cervix. Am. J. Obstet. Gynecol. 63: 674, 1952.

    CAS  Google Scholar 

  12. Candy, J., and Abell, M. R. Progestogen-induced adenoma-tous hyperplasia of the uterine cervix. JAMA 203: 323, 1968.

    Article  Google Scholar 

  13. Chang, S. H. and Maddox, W. A. Adenocarcinoma arising within cervical endometriosis and invading the adjacent vagina. Am. J. Obstet. Gynecol. 110: 1015, 1971.

    PubMed  CAS  Google Scholar 

  14. Clement, P. B., and Scully, R. E. Müllerian adenosarcoma of the uterus. Cancer 34: 1138, 1974.

    Article  PubMed  CAS  Google Scholar 

  15. Cohen, C. Three cases of amoebiasis of the cervix uteri. J. Obstet. Gynaecol. Brit. Commonw. 80: 476, 1973.

    CAS  Google Scholar 

  16. Crossen, R. J. A case of gumma of cervix. Am. J. Obstet. Gynecol. 19: 708, 1930.

    Google Scholar 

  17. Danforth, D. N., Veis, A., Breen, M., Weinstein, H. G., Buckingham, J. C., and Manalo, P. The effect of pregnancy and labor in the human cervix: Changes in collagen, glycoproteins, and glycosaminoglycans. Am. J. Obstet. Gynecol. 120: 641, 1974.

    CAS  Google Scholar 

  18. Dougherty, C. M., Moore, W. R., and Cotten, N. Histologic diagnosis and clinical significance of benign lesions of the nonpregnant cervix. Ann. N.Y. Acad. Sci. 97: 683, 1962.

    Google Scholar 

  19. Dun, A. E. G., and Ogilvie, M. M. Intranuclear virus particles in human genital wart tissue: Observation on the ultrastructure of the epidermal layer. J. Ultrastruct. Res. 22: 282, 1968.

    Article  PubMed  CAS  Google Scholar 

  20. Elliott, G. B., and Elliott, J. D. A. Superficial stromal reactions of lower genital tract. Arch. Pathol. 95: 100, 1973.

    PubMed  CAS  Google Scholar 

  21. Elliott, G. B., Reynolds, H. A., and Fidler, H. K. Pseudo-sarcoma botryoides of cervix and vagina in pregnancy. J. Obstet. Gynaecol. Brit. Commonw. 74: 728, 1967.

    Article  CAS  Google Scholar 

  22. El-Mahgoub, S. Antispermatozoal antibodies in infertile women with cervicovaginal schistosomiasis. Am. J. Obstet. Gynecol. 112: 781, 1972.

    CAS  Google Scholar 

  23. Farrar, H. K. Jr., and Nedoss, B. R. Benign tumors of the uterine cervix. Am. J. Obstet. Gynecol. 81: 124, 1961.

    Google Scholar 

  24. Ferenczy, A., and Richart, R. M. Female Reproductive System. Dynamics of Scan and Transmission Electron Microscopy, 1st ed. New York, John Wiley & Sons, 1974.

    Google Scholar 

  25. Fingerland, A., and Sikl, H. Ganglioneuroma of cervix uteri. J. Pathol. Bacterol. 47: 631, 1938.

    Article  Google Scholar 

  26. Fluhman, C. F. The Cervix Uteri and Its Diseases, 1st ed. Philadelphia, W. B. Saunders, 1961.

    Google Scholar 

  27. Gardner, H. L. Cervical and vaginal endometriosis. Clin. Obstet. Gynecol. 9: 358, 1966.

    CAS  Google Scholar 

  28. Gardner, H. L., and Fernet, P. Etiology of vaginitis emphysematosa. Am. J. Obstet. Gynecol. 88: 680, 1964.

    CAS  Google Scholar 

  29. Gilbert, E. F., and Palladino, A. Squamous papillomas of the uterine cervix: review of the literature and report of a giant papillary carcinoma. Am. J. Clin. Pathol. 46: 115, 1966.

    PubMed  CAS  Google Scholar 

  30. Godforth, J. L. Polyps and papillomas of the cervix uteri. Texas State J. Med. 49: 81, 1953.

    Google Scholar 

  31. Govan, A. D. T., Black, W. P., and Sharp, J. L. Aberrant glandular polypi of the uterine cervix associated with contraceptive pills: pathology and pathogenesis. J. Clin. Pathol. 22: 84, 1969.

    Article  PubMed  CAS  Google Scholar 

  32. Greene, R. R., and Peckham, B. M. Squamous papillomas of the cervix. Am. J. Obstet. Gynecol. 67: 883, 1954.

    CAS  Google Scholar 

  33. Grimait, M., Argueles, M., and Ferenczy, A. Papillary cystadenofibroma of endometrium. A histochemical and ultra-structural study. Cancer 36: 137, 1975.

    Article  Google Scholar 

  34. Gusdon, J. T. Hemangioma of the cervix. Am. J. Obstet. Gynecol. 91: 204, 1965.

    CAS  Google Scholar 

  35. Henriksen, E. Lipoma of the uterus. Report of 3 cases. West. J. Surg. 60: 609, 1952.

    CAS  Google Scholar 

  36. Janovski, M. S., and Kasdon, E. J. Benign mesonephric papillary and polypoid tumors of the cervix in childhood. J. Pediatr. 63: 211, 1963.

    Article  PubMed  CAS  Google Scholar 

  37. Jiji, V. Blue nevus of the endocervix. Review of literature. Arch. Pathol. 92: 203, 1971.

    PubMed  CAS  Google Scholar 

  38. Kaufman, R. H., Gardner, H. L., Rawls, W. E., Dixon, R. E., and Young, R. L. Clinical features of herpes genitalis. Cancer Res. 33: 1446, 1973.

    PubMed  CAS  Google Scholar 

  39. Kaufman, R. H., and Watts, J. M., and Gardner, H. L. Pemphigus vulgaris genital involvement. Obstet. Gynecol. 33: 264, 1969.

    PubMed  CAS  Google Scholar 

  40. Kistner, R. W., and Hertig, A. T. Papillomas of the uterine cervix—their malignant potentiality. Obstet. Gynecol. 6: 147, 1955.

    PubMed  CAS  Google Scholar 

  41. Koss, L. G., and Wolinska, W. H. Trichomonas vaginalis cervicitis and its relationship to cervical cancer; a histocytological study. Cancer 12: 1171, 1959.

    Article  PubMed  CAS  Google Scholar 

  42. Kyriakos, M., Kempson, R. L., and Konikor, N. F. A clinical and pathologic study of endocervical lesions associated with oral contraceptives. Cancer 22: 99, 1968.

    Article  PubMed  CAS  Google Scholar 

  43. Langley, G. F. Primary echinococcal cyst of the uterus. Br. J. Surg. 30: 278, 1943.

    Google Scholar 

  44. Lippert, L. J., Richart, R. M., and Ferenczy, A. Giant benign endocervical polyp: Report of a case. Am. J. Obstet. Gynecol. 118: 1140, 1974.

    PubMed  CAS  Google Scholar 

  45. Lucas, W. E., Benirschke, K., and Lebherz, T. B. Verrucous carcinoma of the female genital tract. Am. J. Obstet. Gynecol. 119: 435, 1974.

    CAS  Google Scholar 

  46. Maqueo, M., Azuela, J. C., Calderon, J. J., and Goldzieher, J. W. Morphology of the cervix in women treated with synthetic progestins. Am. J. Obstet. Gynecol. 96: 994, 1966.

    CAS  Google Scholar 

  47. Marsh, M. R. Papilloma of the cervix. Am. J. Obstet. Gynecol. 64: 281, 1952.

    CAS  Google Scholar 

  48. Morehead, R. P., Woodruff, W. D., Thomas, W. C., and Winston-Solem, N. C. Granuloma pyogenicum of the cervix. Am. J. Obstet. Gynecol. 47: 546, 1944.

    Google Scholar 

  49. Murray, H. L. Hydatid cyst of the cervix uteri. Lancet 1: 911, 1926.

    Google Scholar 

  50. Nahmias, A. J., Dowdle, W. R., Naib, Z., Josey, W., McClone, D., and Domescik, G. Genital infection with type 2 herpes virus hominis A commonly occurring venereal disease. Br. J. Vener. Dis. 45: 294, 1969.

    PubMed  CAS  Google Scholar 

  51. Nahmias, A. J., and Roizman, B. Infection with Herpes-simplex viruses 1 and 2. N. Engl. J. Med. 289: 667, 719, 781, 1973.

    Article  Google Scholar 

  52. Naib, Z. M., Nahmias, A. J., and Josey, W. E. Cytology and histopathology of cervical Herpes simplex infection. Cancer 19: 1026, 1966.

    Article  PubMed  CAS  Google Scholar 

  53. Newton, W. L., Reardon, L. V., and DeLeva, A. M. A comparative study of the subcutaneous innoculation of germ free and conventional guinea pigs with two strains of Trichomonas vaginales. Am. J. Trop. Med. Hyg. 9: 56, 1960.

    CAS  Google Scholar 

  54. Nichols, T. M., and Fidler, H. K. Microglandular hyperpla sia in cervical cone biopsies taken for suspicious and positive cytology. Am. J. Clin. Pathol. 56: 424, 1971.

    PubMed  CAS  Google Scholar 

  55. Niven, P. A. R., and Stansfeld, A. G. “Glioma” of the uterus. A fetal homograft. Am. J. Obstet. Gynecol. 115: 534, 1973.

    PubMed  CAS  Google Scholar 

  56. Nogales, F., and Vilar, E. Etude chimique et thérapeutique de la tuberculose du col utérin. (Travail basé sur l’étude de 102 cas). Rev. Franç. Gynecol. 52: 275, 1957.

    CAS  Google Scholar 

  57. Norris, H. J., and Taylor, H. B. Polyps of the vagina: A benign lesion resembling sarcoma botryoides. Cancer 19: 226, 1966.

    Google Scholar 

  58. Overton, D. H., Wilson, R. B., and Dockerty, M. B. Primary endometriosis of the cervix. Am. J. Obstet. Gynecol. 79: 768, 1960.

    Google Scholar 

  59. Pedowitz, P. Vascular tumors of the uterus. Am. J. Obstet. Gynecol. 69: 1291, 1955.

    CAS  Google Scholar 

  60. Pund, E. R., and Greenblatt, R. B. Granuloma venerum of cervix uteri (granuloma inguinale) simulating carcinoma. JAMA 108: 1401, 1937.

    Article  Google Scholar 

  61. Richart, R. M. Cervical intraepithelial neoplasia, in Sommers, C. C. ed.: Pathology Annual. New York, Appleton-CenturyCrofts, 1973, pp. 301–328.

    Google Scholar 

  62. Richter, G. A., Pratt, J. H., Nichols, D. R., and Coulam, C. B. Actinomycosis of the female genital organs. Minn. Med. 55: 1003, 1972.

    PubMed  CAS  Google Scholar 

  63. Ridley, J. H. The histogenesis of endometriosis. A review of facts and fancies. Obstet. Gynecol. Surv. 23: 1, 1968.

    Google Scholar 

  64. Rilke, F., and Cantaboni, A. Lipomas of the uterus. Presentation of 2 cases and review of the recent literature. Ann. Ostet. Gynecol. 86: 645, 1964.

    CAS  Google Scholar 

  65. Saier, F. L., Hovadhanakul, P., and Ostapowicz, F. Giant cervical polyp. Obstet. Gynecol. 41: 94, 1973.

    CAS  Google Scholar 

  66. Schaefer, C. Tuberculosis of female genital tract. Clin. Obstet. Gynecol. 13: 965, 1970.

    CAS  Google Scholar 

  67. Selzer, F., and Nelson, H. M. Benign papilloma (polypoid tumor) of the cervix uteri in children; report of two cases. Am. J. Obstet. Gynecol. 84: 165, 1962.

    PubMed  CAS  Google Scholar 

  68. Sered, H., Falls, F. H., and Zummo, F. H. Recent trends in management of tuberculosis of the cervix. J. Int. Coll. Surg. 20:409,1953.

    PubMed  CAS  Google Scholar 

  69. Stein, B. J., and Siciliano, A. Necrotizing Herpes simplex viral infection of the cervix during pregnancy: Mimic of squamous cell carcinoma. Am. J. Obstet. Gynecol. 94: 249, 1966.

    PubMed  CAS  Google Scholar 

  70. Stout, A. P. Hemangio-endothelioma: A tumor of blood vessels featuring vascular endothelial cells. Ann. Surg. 118: 445, 1943.

    Article  PubMed  CAS  Google Scholar 

  71. Taylor, H. B., Irey, N. S., and Norris, H. J. Atypical endocervical hyperplasia in women taking oral contraceptives. JAMA 202: 637, 1967.

    Article  PubMed  CAS  Google Scholar 

  72. Vellios, F., Ng, A. B. P., and Reagan, J. W. Papillary adenofibroma of the uterus. A benign mesodermal mixed tumor of Müllerian origin. Am. J. Clin. Pathol. 60: 543, 1973.

    CAS  Google Scholar 

  73. Wagner, E. K. The replication of herpesvirus. Am. Sci. 62: 584, 1974.

    CAS  Google Scholar 

  74. Wilbanks, G. D., and Carter, B. Vaginitis emphysematosa. Obstet. Gynecol. 22: 301, 1963.

    CAS  Google Scholar 

  75. Wolfe, S. A. Papilloma of the cervix. Am. J. Obstet. Gynecol. 60: 448, 1950.

    CAS  Google Scholar 

  76. Wolfe, S. A., Mackles, A., and Greene, H. J. Endometriosis of the cervix. Am. J. Obstet. Gynecol. 81: 111, 1961.

    CAS  Google Scholar 

  77. Woodruff, J. D., and Peterson, W. F. Condylomata acuminata of the cervix. Am. J. Obstet. Gynecol. 75: 1354, 1958.

    CAS  Google Scholar 

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  1. Alex Ferenczy M.D.
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  1. New York University School of Medicine, New York, New York, USA

    Ancel Blaustein (Clinical Professor of Pathology) (Clinical Professor of Pathology)

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Ferenczy, A. (1977). Benign Lesions of the Cervix. In: Blaustein, A. (eds) Pathology of the Female Genital Tract. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-6143-6_6

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  • DOI: https://doi.org/10.1007/978-1-4757-6143-6_6

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