Abstract
Although the cervix was recognized as an organ entity as early as 4500 B.C. during the third Egyptian Dynasty, it was Soranus, in the first century A.D., who gave the first accurate description of the cervix uteri as a separate portion of the uterus.48 The cervix (term taken from the Latin, meaning “neck”) is the most inferior portion of the uterus protruding into the upper vagina. The vagina is fused circumferentially and obliquely around the distal part of the cervix, dividing it into an upper, supravaginal and lower, vaginal portion.26 The cervix is generally cylindrical in shape, measures in the adult nulligravida 2.5 to 3.0 cm in length, and its normal position is slightly angulated downward and backward. The vaginal portion (portio vaginalis) of the cervix, also referred to as the exocervix, is delimited by the anterior and posterior fornices and has a convex elliptical surface. It is covered by a smooth, shiny squamous mucous membrane and centered by the external os, a circular (in the nulligravida) or slitlike (in the parous woman) opening (Figure 5.1). The portio may be divided into anterior and posterior lips, of which the anterior is shorter and projects lower than its posterior counterpart. The external os is interconnected with the isthmus (internal os) by the cervical canal. The canal is an elliptical, fusiform cavity, measuring in its greatest width 8 mm, and contains longitudinal mucosal ridges, the plicae palmatae (Figure 5.2). These, when hypertrophied or fused because of inflammation, may render the introduction of a uterine curette or dilator difficult because they form blind passages in the canal. The area between the endocervical and endometrial cavity is called the isthmus or lower uterine segment. The latter term is used principally for descriptive purposes during gestation and labor. The use of the terms anatomic and histologic “internal os” seems arbitrary as no convincing morphologic evidence is offered to support such a geographic subdivision of the uterus and the uterus may be divided into corpus, isthmus, and cervix. The muscular layer in the region of the isthmus is less developed than in the corpus, a feature that facilitates effacement and dilatation during labor. The blood supply of the cervix is provided by the descending branches of the uterine arteries, reaching the lateral walls along the upper margin of the paracervical ligaments (cardinal ligaments of Mackenrodt). These ligaments are the main source of fixation, support, and suspension of the organ. Another means of fixation is provided by the uterosacral ligaments, which attach the supravaginal portion of the cervix to the second through fourth sacral vertebrae. Excision of nerve fibers (denervation) within these ligaments is used to relieve intractable dysmenorrhea. The venous drainage parallels the arterial system, with communication between the cervical plexus and neck of the urinary bladder. The lymphatics of the cervix have a dual origin:36 beneath the mucosa and deep in the fibrous stroma. Both systems collect into two lateral plexuses in the region of the isthmus and give origin to four efferent channels running toward: (1) the external iliac and obturator nodes, (2) the hypogastric and common iliac nodes, (3) the sacral nodes, and (4) the nodes of the posterior wall of the urinary bladder. The innervation of the cervix is chiefly limited to the endocervix and peripheral deep portion of the exocervix.26 This distribution is responsible for the relative insensitivity to pain of the portio vaginalis. The cervical nerves derive from the pelvic autonomic system, the superior, middle, and inferior hypogastric plexuses.
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References
Ashworth, C. T., Luibel, F., and Sanders, E. Epithelium of normal cervix uteri studied with electron microscopy and histochemistry. Am. J. Obstet. Gynecol. 79: 1149, 1960.
Averette, H. E., Weinstein, G. 13., and Frost, P. Autoradio-graphic analysis of cell proliferation kinetics in human genital tissues. I. Normal cervix and vagina. Am. J. Obstet. Gynecol. 108: 8, 1970.
Chretien, F. C., Gernigon, C., David, G., and Psychoyos, A. The ultrastructure of human cervical mucus under scanning electron microscopy. Fertil. Steril. 24: 746, 1973.
Coppleson, M., Pixley, E., and Reid, B. Colposcopy. A Scientific and Practical Approach to the Cervix in Health and Disease, 1st ed. Springfield, Ill., Charles C Thomas, 1971.
Coppleson, M., and Reid, B. Preclinical Carcinoma of the Cervix Uteri, 1st ed. Oxford, Pergamon Press, 1967.
Danforth, D. N. The distribution and functional activity of the cervical musculature. Am. J. Obstet. Gynecol. 68: 1261, 1954.
Danforth, D. N., Veis, A., Breen, M., Weinstein, H. G., Buckingham, J. C., and Manalo, P. The effect of pregnancy and labor in the human cervix: Changes in collagen, glycoproteins, and glycosaminoglycans. Am. J. Obstet. Gynecol. 120: 641, 1974.
Dougherty, C. M., Moore, W. R., and Cotten, N. Histologic diagnosis and clinical significance of benign lesions of the nonpregnant cervix. Ann. N.Y. Acad. Sci. 97: 683, 1962.
Epperson, J. W. W., Hellman, L. M., Galvin, G. A., and Busby, T. The morphological changes in the cervix during pregnancy, including intraepithelial carcinoma. Am. J. Obstet. Gynecol. 61: 50, 1951.
Fand, S. B. The histochemistry of human cervical epithelium, in Blandau, R. J., and Maghissi, K. S., eds.: The Biology of the Cervix. Chicago, University of Chicago Press, 1973, pp. 103–124.
Ferenczy, A., and Richart, R. M. Scanning electron microscopy of the cervical transformation zone. Am. J. Obstet. Gynecol. 115: 151, 1973.
Ferenczy, A., and Richart, R. M. Female Reproductive System. Dynamics of Scan and Transmission Microscopy, 1st ed. New York, John Wiley and Sons, 1974.
Fluhman, C. F. The Cervix Uteri and Its Diseases, 1st ed. Philadelphia, W. B. Saunders, 1961.
Foraker, A. G., and Marino, G. Glycogen-synthesizing enzymes in the uterine cervix. Obstet. Gynecol. 17: 311, 1961.
Foraker, A. G., and Wingo, W. J. Protein bound sulfhydryl and disulfide group in squamous carcinoma of the uterine cervix. Am. J. Obstet. Gynecol. 71: 1182, 1956.
Forsberg, J. G. Estrogen, vaginal cancer, and vaginal development. Am. J. Obstet. Gynecol. 113: 83, 1972.
Friedrich, E. R. The normal morphology and ultrastructure of the cervix, in Blandau, R. J., and Maghissi, K. S., eds.: The Biology of the Cervix. Chicago, University of Chicago Press, 1973, pp. 79–102.
Hackeman, M., Grubb, C., and Hill, K. R. The ultrastructure of normal squamous epithelium of the human cervix uteri. J. Ultrastruct. Res. 22: 443, 1968.
Hamperl, H., and Kaufmann, C. The cervix uteri at different ages. Obstet. Gynecol. 14: 621, 1959.
Hart, W. R., and Norris, H. J. Cervix adenocarcinoma of mesonephric type. Cancer 29: 106, 1972.
Herbst, A. L., Poskanzer, D. C., Robboy, S. J., Friedlander, L., and Scully, R. E. Prenatal exposure to stilbestrol. N. Engl. J. Med. 292: 334, 1975.
Johnson, L. D. The histopathological approach to early cervical neoplasia. Obstet. Gynecol. Surv. 24: 735, 1969.
Johnson, L. D. Dysplasia and carcinoma in-situ in pregnancy, in Norris, H. J., Hertig, A. T., and Abell, M. R., eds.: The Uterus, Internatl. Acad. Path. Monogr. Baltimore, Williams and Wilkins, 1973, pp. 382–412.
Kolstad, P., and Staff, A. Atlas of Colposcopy, 1st ed. Baltimore, University Park Press, 1972.
Koss, L. G. Diagnostic Cytology and Its Histopathologic Bases, 2nd ed. Philadelphia, J. B. Lippincott, 1968.
Krantz, K. E. The anatomy of the human cervix, gross and microscopic, in Blandau, R. J., and Moghissi, K., eds.: The Biology of the Cervix. Chicago, University of Chicago Press, 1973, pp. 57–69.
Llanes, A., Farre, C., Ferenczy, A., and Richart, R. M. Scanning electron microscopy of normal exfoliated squamous cervical cells. Acta Cytol. 17: 507, 1973.
Mackles, A., Wolfe, S. A., and Neigus, I. Benign and malignant mesonephric lesions of the cervix. Cancer 11: 292, 1958.
McGee, C. T., Cromer, D. W., and Greene, R. R. Mesonephric carcinoma of the cervix. Differentiation from endocervical adenocarcinoma. Am. J. Obstet. Gynecol. 84: 358, 1962.
Meyer, R. The basis of the histological diagnosis of carcinoma with special reference to carcinoma of the cervix and similar lesions. Surg. Gynecol. Obstet. 73: 14, 1941.
Nicholson, G. W. Sebaceous glands in the cervix uteri. J. Pathol. Bacteriol. 22: 252, 1918.
Novak, E., Woodruff, J. D., and Novak, E. R. Probable mesonephric origin of certain female genital tumors. Am. J. Ob-stet. Gynecol. 68: 1222, 1954.
Odeblad, E. The functional structure of human cervical mucus. Acta Obstet. Gynecol. Scand. 47 (Suppl. 1): 57, 1968.
Philipp, E. On the granulo-filamentary transformation of secretory granules in the mucous producing epithelium of the human endocervix. Z. Zellforsch. Mikrosk. Anat. 134: 555, 1972.
Philipp, E., and Overbeck, L. Die Ultrastuktur des Zervixepithels. Z. Geburtsh. Gynaek. 171: 159, 1969.
Reiffenstuhl, G. The Lymphatics of the Female Genital Organs, 1st ed. Philadelphia, J. B. Lippincott, 1964.
Richart, R. M. A radioautographic analysis of cellular proliferation in dysplasia and carcinoma in situ of the uterine cervix. Am. J. Obstet. Gynecol. 86: 925, 1963.
Richart, R. M. The growth characteristics in vitro of normal epithelium, dysplasia and carcinoma in situ of the uterine cervix. Cancer Res. 24: 662, 1964.
Richart, R. M. Colpomicroscopic studies of the distribution of dysplasia and carcinoma in situ on the exposed portion of the human uterine cervix. Cancer 18: 950, 1965.
Richart, R. M. Colpomicroscopic studies of cervical intraepithelial neoplasia. Cancer 19: 395, 1966.
Richart, R. M. Natural history of cervical intraepithelial neoplasia. Clin. Obstet. Gynecol. 10: 748, 1967.
Richart, R. M. Cervical intraepithelial neoplasia, in Sommers, C. C., ed.: Pathology Annual. New York, Appleton-CenturyCrofts, 1973, pp. 301–328.
Roth, E., and Raylor, H. B. Heterotopic cartilage in the uterus. Obstet. Gynecol. 27: 838, 1966.
Schellhas, H. F., and Heath, G. Cell renewal in the human cervix uteri. A radioautographic study of DNA, RNA, and protein synthesis. Am. J. Obstet. Gynecol. 104: 617, 1969.
Scherrick, J. C., and Vega, J. G. Congenital intramural cysts of the uterus. Obstet. Gynecol. 19: 486, 1962.
Singer, A., and Reid, B. L. Effects of the oral contraceptive steroids on the ultrastructure of human cervical mucus. J. Reprod. Fertil. 23: 249, 1970.
Staff, A., and Mattingly, R. F. Vaginal adenosis: A pre-cancerous lesion ? Am. J. Obstet. Gynecol. 120: 666, 1974.
Temkin, O. (Translator). Soranus’ Gynecology. Baltimore, Johns Hopkins University Press, 1956.
Whaley, W. G., Dauwalder, M., and Kephart, J. E. Golgi apparatus: Influence on cell surface. Science 175: 596, 1972.
Wilbanks, G. D., and Richart, R. M. The puerperal cervix, injuries and healing: A colposcopic study. Am. J. Obstet. Gynecol. 97: 1105, 1967.
Williams, A. E., Jordan, J. A., Allen, J. M., and Murphy, J. F. The surface ultrastructure of normal and metaplastic cervical epithelia and of carcinoma in situ. Cancer Res. 33: 504, 1973.
Willis, R. A. The Borderland of Embryology and Pathology, 2nd ed. Washington, D.C., Butterworth, 1962.
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Ferenczy, A. (1977). Anatomy and Histology of the Cervix. In: Blaustein, A. (eds) Pathology of the Female Genital Tract. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-6143-6_5
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DOI: https://doi.org/10.1007/978-1-4757-6143-6_5
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