Pathologic Factors Involved in Infertility

  • Charles Debrovner


A survey of pathologic factors involved in infertility reveals that in roughly one-quarter of this population the cause is exclusively male and in one-quarter the problem is exclusively female. In a third quarter, there is a dual problem. In some of these cases it is additive and in other cases it is not. An example may be a man who is azospermic and married to a woman with tubal occlusion. In this case they each have a problem, but the problem is not additive. In contrast, a man with a borderline semen may be married to a woman with relatively hostile cervical mucus. In this case, the two problems potentiate each other. If the same man were married to a woman with a very healthy hospitable cervical mucus, pregnancy would probably occur. If the woman were married to a man with a more vigorous sperm population, again, pregnancy would likely occur.


Fallopian Tube Corpus Luteum Uterine Cavity Ovarian Failure Pathologic Factor 
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  1. 1.
    Addams, C. E., and Chang, M. D. Capacitation of rabbit spermatozoa in the fallopian tube and in the uterus. J. Exp. Zool. 151: 159, 1962.CrossRefGoogle Scholar
  2. 2.
    Asherman, J. G. Amenorrhea traumatica. J. Obstet. Gynaecol. Br. Emp. 55: 23, 1948.CrossRefGoogle Scholar
  3. 3.
    Asherman, J. G. Uterine synechiae. Bull. Fed. Gynaecol. Obstet. Fran. 9: 490, 1957.Google Scholar
  4. 4.
    Austin, C. R. Observations on the penetration of the sperm into the mammalian egg. Aust. J. Sci. Res. 4: 581, 1951.Google Scholar
  5. 5.
    Austin, C. R. The capacitation of mammalian sperm. Nature (London) 170: 326, 1952.CrossRefGoogle Scholar
  6. 6.
    Baramki, T. A., and Jones, H. W. Jr. Early premature menopause. Am. J. Obstet. Gynecol. 96: 990, 1966.Google Scholar
  7. 7.
    Behrman, S. J. Agglutinins, antibodies, and immune reactions. Clin. Obstet. Gynecol. 8: 91, 1965.Google Scholar
  8. 8.
    Behrman, S. J. Immunologic Aspects of Fertility and Infertility in Agents Affecting Fertility. ( Biological Council Symposium) London, Churchill, 1965, p. 47.Google Scholar
  9. 9.
    Behrman, S. J. Immunologic phenomenon in infertility: Some clinical applications. Harper Hosp. Bull. 24: 147, 1966.Google Scholar
  10. 10.
    Bishop, D. W. Metabolic conditions within the oviduct of the rabbit. Int. J. Fertil. 2: 11, 1957.Google Scholar
  11. 11.
    Black, D. L., and Asdell, S. A. Transport to the rabbit oviduct. Am. J. Physiol. 192: 63, 1958.Google Scholar
  12. 12.
    Black, D. L., and Asdell, S. A. Mechanism controlling the entry of ova into the rabbit uterus. Am. J. Physiol. 197: 1275, 1959.PubMedGoogle Scholar
  13. 13.
    Blaustein, A., and Shenker, L. Data to be published, 1975.Google Scholar
  14. 14.
    Brackett, B. G., and Williams, W. L. In vitro fertilization of rabbit ova. J. Exp. Zool. 160:277, 1965.Google Scholar
  15. 15.
    Burdick, H. O., Whitney, R., and Emerson, B. Observations on the transport of tubal ova. Endocrinology 31: 100, 1942.CrossRefGoogle Scholar
  16. 16.
    Buxton, C. L., and Wong, A. S. H. Spermicidal bacteria in the cervix as a cause of sterility. Am. J. Obstet. Gynecol. 64: 628, 1952.Google Scholar
  17. 17.
    Chang, M. C. A detrimental effect of seminal plasma of the fertilizing capacity of sperm. Nature (London) 285: 258, 1957.CrossRefGoogle Scholar
  18. 18.
    Clewe, T. H., and Mastroianni, L. Jr. Mechanisms of ovum pick up: One functional capacity of rabbit oviducts ligated near the fimbria. Fertil. Steril. 9: 13, 1958.Google Scholar
  19. 19.
    Creadick, R. N. Non-surgical treatment of endometriosis-A preliminary report on the use of methyl testosterone. N.C. Med. J. 11: 576, 1950.Google Scholar
  20. 20.
    Dmowski, W. P., and Cohen, M. R. Treatment of endometriosis with an antigonadotrophin, Danazol. Obstet. Gynecol. 46: 147, 1975.PubMedGoogle Scholar
  21. 21.
    Foss, B. A., Horne, H. W. Jr., and Hertig, A. T. The endometrium and sterility. Fertil. Steril. 9: 193, 1958.Google Scholar
  22. 22.
    Franklin, R., and Dukes, C. D. Anti spermatozoa antibody and unexplained infertility. Am. J. Obstet. Gynecol. 89: 6, 1964.PubMedGoogle Scholar
  23. 23.
    Freund, M. Standards for the rating of human sperm morphology-A cooperative study. Int. J. Fertil. (Suppl.) 11: 97, 1966.Google Scholar
  24. 24.
    Greenwald, G. S. A study of the transport of ova through the rabbit oviduct. Fertil. Steril. 12: 80, 1961.Google Scholar
  25. 25.
    Gregoire, A. T., Gongsaldi, D., and Rakoff, A. E. The amino acid content of female rabbit genital tract. Fertil. Steril. 12: 322, 1961.Google Scholar
  26. 26.
    Ingersall, F. M. Fertility following myomectomy. Fertil. Steril. 14: 596, 1963.Google Scholar
  27. 27.
    Irvine, W. J., Chan, M. W., and Scarth, L. The further characterization of auto-antibodies reactive with extra-adrenal steroid-producing cells in patients with adrenal disorders. Clin. Exp. Immunol. 4: 489, 1969.Google Scholar
  28. 28.
    Jones, G. E. S. Luteal phase defects. In Behrman, S. J. and Kistner, R. W., eds. Progress in Infertility. Boston, Little Brown, 1968, p. 299.Google Scholar
  29. 29.
    Jones, G. E. S., Woodruff, D. J., and Moszkowskie. The inadequate luteal phase. Am. J. Obstet. Gynecol. 83: 363, 1962.Google Scholar
  30. 30.
    Jones, H. W. Jr., Ferguson-Smith, M. A., and Heller, R. H. The pathology and cytogenetics of gonadal agenesis. Am. J. Ob-stet. Gynecol. 87: 578, 1963.Google Scholar
  31. 31.
    Karnaky, J. K. Endometriosis. In Conn, H. T., ed. Current Therapy. Philadelphia, W. B. Saunders, 1957, p. 676.Google Scholar
  32. 32.
    Kistner, R. W. New progestins in the treatment of endometriosis. Am, J. Obstet. Gynecol. 75: 264, 1958.Google Scholar
  33. 33.
    Kunitake, G., and Davagan, V. A new method of evaluating infertility due to cervical mucous spermatazoa incompatibility. Fertil. Steril. 21: 706, 1970.PubMedGoogle Scholar
  34. 34.
    MacLeod, J. Semen quality in 1,000 men of known fertility and in 800 cases of infertile marriage. Fertil. Steril. 2: 115, 1951.Google Scholar
  35. 35.
    MacLeod, J. The semen examination. Clin. Obstet. Gynecol. 8: 115, 1965.CrossRefGoogle Scholar
  36. 36.
    Marcus, C. C., and Marcus, S. L. The cervical factor in infertility. Clin. Obstet. Gynecol. 8: 15, 1965.CrossRefGoogle Scholar
  37. 37.
    Marcus, S. L., and Marcus, C. C. Cervical mucous and its relation to infertility. Obstet. Gynecol. Surv. 18: 749, 1963.Google Scholar
  38. 38.
    Masters, W. H., and Johnson, V. E. Human Sexual Response. Boston, Little, Brown, 1966, p. 97.Google Scholar
  39. 39.
    Moghiissi, K. S., Dabich, D., Levine, J., and Neuhaus, O. W. Mechanism of sperm migration. Fertil. Steril. 15: 15, 1964.Google Scholar
  40. 40.
    Moghissi, K. S., and Neuhaus, O. W. Composition and properties of human cervical mucous. Am. J. Obstet. Gynecol. 83: 149, 1962.PubMedGoogle Scholar
  41. 41.
    Moraes-Ruehsen, M., and Jones, G. S. Premature ovarian failure. Acta Obstet. Gynecol. Scand. 52: 259, 1973.CrossRefGoogle Scholar
  42. 42.
    Nathanson, I. T., Rice, C., and Meigs, J. V. Hormone studies in artificial menopause produced by roentgen rays. Am. J. Obstet. Gynecol. 40: 935, 1940.Google Scholar
  43. 43.
    Noyes, R. W. The capacitation of rabbit spermatozoa. J. Endocrinol. 17: 374, 1958.PubMedCrossRefGoogle Scholar
  44. 44.
    Noyes, R. W., and Addams, C. E. The transport of spermatozoa into the uterus of the rabbit. Fertil. Steril. 9: 288, 1958.PubMedGoogle Scholar
  45. 45.
    Ruehson, M. de M., Blizzard, R. M., Garcia-Bunuel, R., and Jones, G. E. S. Auto-immunity and ovarian failure. Am. J. Obstet. Gynecol. 112: 693, 1972.Google Scholar
  46. 46.
    Ruehson, M. de M., and Jones, G. E. S. Premature ovarian failure. Fertil. Steril. 18: 440, 1967.Google Scholar
  47. 47.
    Ruehson, M. de M., Jones, G. E. S., Burnett, L. S., and Baramki, T. S. The Aluteal Cycle: A severe form of the luteal phase deficit. Am. J. Obstet. Gynecol. 103: 1059, 1969.Google Scholar
  48. 48.
    Sobrero, A. J., and MacLeod, J. The immediate post coital test. Fertil. Steril. 13: 184, 1962.PubMedGoogle Scholar
  49. 49.
    Soupart, P., and Clewe, T. H. Sperm penetration of rabbit zona pellucida inhibited by treatment of ova with neuraminidase. Fertil. Steril. 16: 677, 1965.PubMedGoogle Scholar
  50. 50.
    Starup, J., and Sele, V. Premature ovarian failure. Acta Obstet. Gynecol. 52: 259, 1973.CrossRefGoogle Scholar
  51. 51.
    Stevenson, C. S. Myomectomy for improvement of fertility. Fertil. Steril. 15: 367, 1964.Google Scholar
  52. 52.
    Sweeney, W. J. Inflammations in infertility, in Progress in Infertility. Boston, Little Brown, 1968, p. 239.Google Scholar
  53. 53.
    Sweeney, W. J. Intrauterine synnechiae. Obstet. Gynecol. 27: 284, 1966.PubMedGoogle Scholar
  54. 54.
    Westmon, A. Studies of the function of the fallopian tube. Int J. Fertil. 4: 201, 1949.Google Scholar
  55. 55.
    Zamboni, L, Hongsanand, C. H., and Mastroianni, L. Jr. Influence of tubal secretions on rabbit tubal ova. Fertil. Steril. 16: 177, 1965.PubMedGoogle Scholar

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© Springer Science+Business Media New York 1977

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  • Charles Debrovner

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